Seeking Guidance on Acquired Anorgasmia
Hello, I’m a 41-year-old woman, weighing 210 pounds and standing at 5’4”, residing in the United States. My daily routine includes taking 18mg of Methylphenidate for ADHD, alongside a daily multivitamin and vitamin D. I also apply estrogen cream every three days. I don’t smoke and drink alcohol infrequently. Initially, I was on Trintellix for depression but transitioned off it, opting for Methylphenidate instead. Although I occasionally smoke cannabis, it’s not a frequent habit—once every few weeks or so. I had been taking Zyrtec daily as well, but I discontinued that once I began experiencing my current symptoms.
Up until July 2025, I was able to reach orgasm consistently through clitoral stimulation, achieving climax every time, whether it was initiated by me or my partner. However, around that time, I suddenly found myself unable to orgasm at all. Concerned about this drastic change, I consulted with my doctor, who prescribed estrogen cream. The result was a slight improvement: I experienced orgasms approximately 10% of the time, but they were far less satisfying than before.
During a follow-up, my doctor speculated that I might have lichen sclerosis. This was perplexing since I had not experienced any prior symptoms. Nevertheless, she referred me to a gynecologist, who shared the same suspicion. After a biopsy, the diagnosis of lichen sclerosis was ruled out, but I was found to have lichen simplex chronicus instead. Interestingly, I don't experience significant itching, which leaves me uncertain about its relevance. Because my orgasmic difficulties persisted, my gynecologist suggested discontinuing the antidepressant, Trintellix, which I did, but unfortunately, this change did not yield any improvement.
In my follow-up with the gynecologist, I inquired about the potential benefits of topical testosterone as suggested by discussions on a perimenopause subreddit. She expressed skepticism, mentioning that my libido remains strong and cautioned about the risk of clitoral changes, yet she proceeded to write a prescription. I have not begun using it due to her reservations. Currently, I am attempting to find a sex therapist, but many are either full or have lengthy waiting lists.
Additionally, I came across information indicating that Zyrtec could interfere with orgasm, prompting me to stop taking it. Consequently, I am now dealing with constant watery eyes from allergies, though I wonder if these symptoms might be due to perimenopause instead. I have found that light cannabis use does provide some relief, and the estrogen cream has helped moderately, yet I still only experience disappointing orgasms about 10% of the time. My libido is quite healthy, and while I often feel aroused and even come close to climax, achieving it still eludes me most of the time. I’ve also noticed that while I may feel aroused, my clitoris does not always exhibit the expected engorgement.
I have an upcoming appointment with my primary care physician next week, where I plan to revisit this issue. I would greatly appreciate any suggestions or considerations for additional options I might discuss with her. It often feels like both my PCP and gynecologist respond with sympathy but lack proactive solutions, only venturing into further investigations like the lichen sclerosis situation.
PsychiatryPsychologyDepression