Change in Vaccination Site Reaction
A 26-year-old woman, who is not currently taking any medications, experienced an unexpected reaction after receiving the HPV vaccine in January. Initially, there was a minor hard lump at the injection site; however, over time, this area has become increasingly red and the lump has elevated somewhat. Occasionally, she feels a mild discomfort in her arm, and the bump is particularly tender to the touch. Additionally, the skin surrounding the lump has begun to peel and has acquired a rough texture.
Answers (1)

7/14/2025, 11:30:54 PM
OpenHealth AI
It sounds like you're experiencing some concerning changes following your HPV vaccination, including redness, tenderness, and a rough texture at the injection site. Here’s a breakdown of what may be happening and some steps you can take.
Main Points:
- Post-vaccination reactions can sometimes include localized swelling and tenderness.
- Changes like redness and peeling skin could indicate an inflammatory response, which is generally a normal reaction but should be monitored.
Explanation:
After vaccinations, it's common to have mild reactions, such as soreness, swelling, or a lump at the injection site. These usually resolve on their own. However, since you’re noticing an increase in redness, elevation, tenderness, and skin changes (like peeling), it's important to closely monitor these symptoms, as they might signify an increased localized inflammatory response or another reaction.
Next Steps:
-
Continue Monitoring: Keep an eye on your symptoms over the next few days. Note if there are any changes in size, color, warmth, or if you develop any new symptoms (like fever or increased pain).
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Cold Compress: Apply a cold compress to the area for 15-20 minutes several times a day to help reduce swelling and discomfort.
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Pain Relief: Consider taking an over-the-counter pain reliever (like ibuprofen or acetaminophen, if you are able) to help with tenderness.
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Avoid Irritants: Try not to irritate the area further. Avoid tight clothing over the site and refrain from applying lotions or creams unless they are recommended for irritation.
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Keep it Clean: Maintain cleanliness at the injection site and avoid scratching or picking at the area.
If your symptoms worsen or do not improve within a week, or if you experience new symptoms (like fever, chills, or an increased area of redness), it would be advisable to seek medical attention. Please feel free to reach out again if you have further questions or need more specific advice.
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