Unexpected Finger Swelling During a Psilocybin Experience
Hello everyone, I’m a 30-year-old woman with generally good health, aside from a minor, monitored bicuspid aortic valve. Today, I ingested a 1-gram psilocybin mushroom chocolate along with 10 mg of propranolol. About two hours into the trip, I started to notice significant swelling and a pressure sensation localized to the pads of my fingers. A couple of hours later, concerned about potential finger swelling—a known serious side effect of propranolol—I opted to visit urgent care; I normally use this medication for performance anxiety without any issues. At the clinic, the doctor reassured me that there was no indication of heart failure, a more severe complication associated with propranolol. They suggested that I might be experiencing an allergic reaction and recommended taking Benadryl, especially since my vital signs were stable. While I felt somewhat reassured that it wasn’t a critical situation, I remained skeptical about the diagnosis. I had never had an allergic reaction to mushrooms before, and the localized swelling in only my fingertip pads felt atypical, with no accompanying symptoms. Consequently, I chose to forgo the Benadryl. I speculated that the swelling could relate to water retention from possible dehydration due to psilocybin-induced diarrhea, although it seemed odd for the swelling to affect only a small area. Upon returning home, I noticed that the pads of my toes might have also been swollen in a similar manner, but I hadn't observed them earlier. Roughly eight hours after consuming the mushrooms, the swelling in my fingers began to diminish and I’m nearly back to normal ten hours later. I’ve searched extensively online but haven’t found anyone else reporting a similar experience. I’d really appreciate any insights regarding what might have caused this issue so that I can discuss it with my doctor, particularly if there are specific health concerns to keep in mind.
Answers (1)
7/15/2025, 4:40:42 AM
OpenHealth AI
Main Points: It's good to hear that the swelling in your fingers has diminished and that you've already seen a doctor. The symptoms you experienced could be related to psilocybin, propranolol, or possibly an unrelated issue. Let's clarify these potential causes and what you can keep an eye on moving forward.
Explanation: Swelling in the fingers and toes can be attributed to a few different factors, especially in the context of recent psilocybin use and propranolol medication:
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Allergic Reaction: Although it seems unusual given your previous mushroom experiences, an allergic reaction to psilocybin could cause localized swelling. However, this is typically accompanied by other symptoms, such as itching or rash.
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Vasodilation or Fluid Retention: Psilocybin can lead to changes in blood circulation and fluid balance, which might explain localized swelling. Anxiety or stress related to the experience could further complicate symptoms, especially during such a psychedelic experience.
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Medication Effects: Propranolol primarily helps manage anxiety but can sometimes cause side effects like swelling in particular individuals. The transient nature of your symptoms may suggest this was not a serious reaction.
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Dehydration and Electrolyte Imbalance: Diarrhea may lead to dehydration, potentially causing fluid retention as your body attempts to balance electrolyte levels. This can affect extremities, such as your fingers and toes.
Next Steps:
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Monitor Symptoms: Continue to keep an eye on any recurring swelling or additional symptoms over the next few days. If swelling returns or is accompanied by additional symptoms (like rash, shortness of breath, etc.), seek medical advice promptly.
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Stay Hydrated: Make sure you are drinking plenty of water, especially if you experience gastrointestinal effects during similar experiences. This can help maintain fluid balance.
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Keep a Symptom Diary: Document any instances of swelling, the time of occurrence, and any related activities or substances consumed. This information can assist your doctor in understanding your situation better.
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Consult a Doctor: When next speaking with your healthcare provider, bring up your experiences, including the swelling, for further evaluation. Discuss any concerns about the interaction of psilocybin and propranolol, even if the symptoms have improved.
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Consider Alternatives: If the swelling recurs or remains a concern, discuss with your healthcare provider the possibility of alternative medications for anxiety management that may not have the same side effects.
It's great that you’re able to follow up with your own observations and concerns. Always prioritize your health and safety when it comes to substances and medications.
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