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Seeking Guidance on Hydroxyzine Discontinuation and Dosage Adjustment

2/8/2026, 12:00:46 AMMale25-34

I've been using hydroxyzine at a dose of 25-50 mg daily for the past five years. I have a dental surgery scheduled this year that will require IV sedation, followed by a week of doxycycline treatment. As such, I'm attempting to eliminate my need for hydroxyzine before then. While numerous sources suggest that withdrawal is minimal or nonexistent, my experience contradicts this; the one time I tried to stop taking it abruptly, I suffered severe itching along with heightened insomnia and anxiety. I'm looking for some guidance on this matter. Additionally, is it advisable to split the 25 mg tablets in order to taper my dosage gradually? For context, I'm a 33-year-old male, standing 5'7" and weighing 240 pounds.

Lifestyle ChangesInternal MedicinePreventive Medicine

Answers (1)

Cony

2/8/2026, 12:01:07 AM

OpenHealth AI

To address your concerns about discontinuing hydroxyzine and managing your dosage effectively, it’s important to proceed carefully to minimize any withdrawal symptoms and ensure your comfort.

Main Points:

  1. Hydroxyzine withdrawal can occur, especially after long-term use, and should be done gradually.
  2. Tapering your dose is advisable, and splitting your tablets can assist with this process.

Explanation: Hydroxyzine is an antihistamine often used for anxiety and allergies. Although many sources suggest that withdrawal symptoms are rare, individual experiences can vary significantly. Symptoms like itching, insomnia, and anxiety, as you've described, may happen if the body is accustomed to regular use and suddenly stops.

Given your past experience with abrupt discontinuation, it’s wise to develop a tapering plan. Gradually reducing your dosage can help to ease any potential withdrawal effects, allowing your system to adjust more comfortably.

Next Steps:

  1. Plan Your Tapering Schedule: Starting with your current dosage of 25-50 mg, consider reducing your dose by 25% every week (e.g., if you take 50 mg, reduce it to 37.5 mg, then 25 mg, etc.). If you experience discomfort, you might need to slow the process. You can adjust the rate based on how you feel.

  2. Tablet Splitting: Yes, splitting your 25 mg tablets can work as long as the tablets are scored for splitting. This will allow you to create smaller doses effectively. If your tablets are not designed to be split, talk to a pharmacist for safer options.

  3. Monitor Symptoms: Keep a record of any withdrawal symptoms or difficulties you experience during the taper. This can help you adjust the tapering speed if necessary and offer insights into how your body is responding.

  4. Self-Care Techniques: Focus on relaxation techniques to manage anxiety during this period: deep breathing exercises, meditation, or light physical activity like walking can be beneficial.

  5. Stay Hydrated: Drink plenty of water, especially as you prepare for your dental surgery and during your doxycycline treatment. Staying hydrated can aid your overall well-being.

If you encounter any severe symptoms or challenges, it would be wise to assess your approach and consider professional support tailored to your situation. Taking these gradual steps should help you manage the transition away from hydroxyzine more smoothly. Let me know if you need further assistance!

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