Is Vyvanse Contributing to My Serotonin Syndrome Symptoms?
**Overview:** I was recently diagnosed with ADHD as an adult. **Current Issue:** For the past several months, I have been taking Vyvanse, beginning with a low dose that has been gradually increased to 60mg. Up until now, I had been managing well, but I have recently started experiencing some concerning side effects. At present, I am also on an SSRI (Sertraline) along with Vyvanse. I have requested to discontinue the SSRI, as I found it to be minimally effective, and I am aware that Vyvanse influences serotonin in addition to dopamine and norepinephrine. I have yet to begin this change in medication until my next consultation. **Here are the symptoms I'm experiencing:** * Experiencing visual disturbances, such as flashing lights in dim environments * Ringing in the ears and auditory difficulties * Involuntary muscle contractions and cramps, especially in my legs and back, even in the absence of physical exertion * Episodes of mental fog and confusion **I suspect that both Vyvanse and my recent lifestyle modifications are contributing factors to my current predicament.** 1. I believe the Vyvanse may be increasing the serotonin levels in my brain, leading to these adverse reactions. Additionally, since I do not take Vyvanse daily—with my doctor's consent—this inconsistency might be causing fluctuations that resemble SSRI withdrawal symptoms. 2. Over the last few months, I've lost a significant amount of weight—around 100 pounds. While Vyvanse has supported this weight loss, I had already been on a dieting regimen prior to starting the medication. I feel that this reduction in my body mass may have intensified my reaction to the medication, given my lowered BMI. Essentially, having a smaller body compounded by the same dosage could be causing amplified effects. I'm eager to hear from anyone who has experience with Vyvanse and serotonin syndrome for some informed advice.
Answers (1)
2/7/2026, 5:40:31 PM
OpenHealth AI
It sounds like you're experiencing some distressing symptoms that may be linked to your current medication regimen, particularly the combination of Vyvanse (a stimulant) and Sertraline (an SSRI). Your concerns about serotonin syndrome and the potential impact of your recent weight loss are valid and worth discussing further.
Overview of Your Situation:
- Vyvanse can increase serotonin levels, but it primarily acts on dopamine and norepinephrine.
- Serotonin syndrome is a rare but serious condition that arises from an excess of serotonin, often when multiple medications affecting serotonin levels are combined.
- Your significant weight loss may alter how your body processes these medications, potentially enhancing side effects.
Symptoms of Concern: The symptoms you’ve described—including visual disturbances, ringing in your ears, muscle contractions, and mental fog—could potentially indicate serotonin syndrome or other medication-related effects. However, they can also stem from various other causes.
Next Steps to Consider:
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Monitor Your Symptoms: Keep a detailed log of your symptoms, noting when they occur and their intensity. This information will be crucial when discussing your condition with your healthcare provider.
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Medication Review: Since you plan to discontinue Sertraline, discuss this transition and your symptoms with your doctor. They might consider adjusting your Vyvanse dosage or changing your medications more comprehensively.
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Consider Dosage and Timing: If you’re taking Vyvanse inconsistently, it might be contributing to fluctuations in how you feel. Your doctor can help you establish a consistent regimen to mitigate these effects.
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Stay Hydrated and Nourished: With significant weight loss, it’s essential to maintain proper hydration and nutrition. This will support your overall health while your medications are adjusted.
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Report Severe Symptoms Promptly: If you experience worsening symptoms such as severe headache, high blood pressure, agitation, or changes in heart rate, seek medical attention immediately. These could signify more serious reactions.
Your experience is unique, and addressing these concerns with a healthcare provider who knows your complete history is essential for a safe transition in your treatment plan. Reach out to them as soon as possible to discuss your symptoms and thoughts on discontinuing the SSRI.
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