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Impact of Coffee on Vyvanse Effectiveness

2/5/2026, 1:50:17 PMMale25-34

Is the acidic nature of coffee a factor in how quickly Vyvanse is absorbed or eliminated from your system? I've heard that doctors advise against taking vitamin C around the same time as this medication. Does this extend to other acidic beverages that can alter urine pH, potentially reducing the effectiveness of Vyvanse? Allow me to provide some context: I'm a 30-year-old woman, weighing 130 pounds and standing 5 feet 4 inches tall (necessary details for moderation purposes).

SupplementsLifestyle ChangesPreventive Medicine

Answers (1)

Cony

2/5/2026, 1:50:33 PM

OpenHealth AI

The interaction between coffee and Vyvanse (lisdexamfetamine) mainly revolves around acidity and its potential effects on the absorption and effectiveness of the medication. Here’s a clear breakdown of your concerns:

Key Points:

  • Acidity and Medication Absorption: The acidic nature of beverages like coffee or vitamin C may affect the urinary pH, which in turn can influence the elimination of certain medications from the body. However, Vyvanse is primarily processed in the liver, and its absorption is not significantly impacted by dietary acidity.
  • Research Evidence: Most studies indicate that while acidic environments can alter the absorption of some medications, Vyvanse remains stable in various pH levels. Therefore, drinking coffee is unlikely to interfere significantly with Vyvanse's effectiveness for most individuals.

Next Steps:

  1. Monitor Symptoms: Pay attention to how you feel after consuming coffee while on Vyvanse. If you notice increased jitteriness or anxiety, consider reducing your coffee intake, as stimulants can compound side effects.

  2. Timing Considerations: If you prefer to minimize any potential interactions, you might choose to separate your coffee consumption from when you take Vyvanse. For example, take your medication on an empty stomach and wait at least 1-2 hours before having coffee.

  3. Hydration: Ensure you remain well-hydrated throughout the day, as dehydration can exacerbate feelings of anxiety or discomfort while taking stimulant medications.

  4. Dietary Choices: While the acidity of coffee isn't a major concern for Vyvanse, it’s a good practice to maintain a balanced diet. Consider incorporating foods rich in nutrients that support mental clarity and focus.

In summary, while coffee’s acidity has some potential to affect medications, Vyvanse is generally not significantly impacted. Keeping a watchful eye on how you feel and adjusting your habits accordingly can be beneficial. If you have any concerning responses or further questions, feel free to ask!

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