Elevated Blood Protein Levels in a 28-Year-Old Male Athlete
Greetings! I am a 28-year-old male endurance athlete who does not smoke or drink alcohol. Over the last four years, I have undergone three Complete Metabolic Panels. Two of these tests were part of routine physical check-ups, while the third was prompted by a temporary gastrointestinal issue. Each time, the results showed that both my Total Protein and Globulin levels were slightly above the normal range. For instance, my Total Protein measured at 9.1 g/dL in both 2022 and 2023, and dropped to 8.5 g/dL in 2026. My Globulin levels were recorded as 4.6 g/dL in 2022, 4.7 g/dL in 2023, and decreased to 3.9 g/dL in 2026. My general practitioner has expressed no concern regarding these findings and does not think they need further examination. I recognize that dehydration can lead to such results, but I felt adequately hydrated during my most recent test. I am wondering if it might be wise to pursue additional testing to eliminate the possibility of Monoclonal Gammopathy of Undetermined Significance (MGUS), or perhaps seek a referral to a Rheumatologist. There is a family history of autoimmune disorders, including Lupus, Sjogren’s syndrome, and Ulcerative Colitis, coupled with a few other unusual medical incidents that could suggest an underlying autoimmune condition. Recently, I had a negative Antinuclear Antibody (ANA) test and a colonoscopy that was mostly clear—with one polyp removed before it could be sent for pathology. Any advice or insights regarding my situation would be greatly valued. Thank you!
Answers (1)
2/3/2026, 6:40:41 PM
OpenHealth AI
Thank you for sharing your detailed medical history and concerns. It’s understandable to be cautious given your family history of autoimmune disorders and the slightly elevated protein levels in your tests. Here’s an overview focusing on what you might consider moving forward.
Main Points
- Elevated Protein Levels: Slightly elevated total protein and globulin levels can be influenced by various factors, including hydration status, exercise intensity, and even normal physiological variations.
- Family History and Testing: Given your family history of autoimmune conditions, it's reasonable to remain vigilant and consider further testing if you have concerns.
Explanation
Your results indicate slight elevations in total protein and globulin, but these are not uncommon in athletes, especially if you're engaged in rigorous training. Dehydration can indeed affect these levels, but if you felt adequately hydrated, other factors could also be at play, such as the body’s response to exercise.
The ANA test being negative is a positive indication that systemic lupus erythematosus is less likely, especially given that this test is often used as a preliminary screening for autoimmune diseases.
Next Steps
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Monitor Symptoms: Keep an eye on any potential symptoms related to autoimmune issues, such as joint pain, fatigue, or skin changes.
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Review Hydration and Diet: Ensure you maintain good hydration and a balanced diet rich in fruits, vegetables, and lean proteins, as these can help optimize your health and potentially influence protein levels.
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Consider Additional Testing: If you remain concerned or experience new symptoms, it might be worthwhile to discuss the possibility of further assays to assess for conditions like MGUS or to evaluate specific autoimmune markers beyond ANA. Discuss your thoughts with your general practitioner to see if there are specific tests they would recommend.
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Documentation: Keep a health journal documenting your symptoms, hydration status, diet, and exercise regime. This will help you or any healthcare providers identify trends or concerns over time.
While your general practitioner feels reassured by your results, it’s always important to trust your instincts regarding your health. Keeping an open line of communication with them about your ongoing concerns will help ensure you receive the care that aligns with your needs. Please let me know if there's anything else you'd like to address!
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