Combining Midodrine and Amlodipine: Is it Advisable?
At 27 years old, I face several persistent health challenges, with notable conditions including Hypermobile Ehlers-Danlos Syndrome (HEDS), Interstitial Cystitis (IC), and Borderline Personality Disorder (BPD). Recently, after consulting a heart specialist, I received a diagnosis of Dysautonomia, which led to the prescription of Midodrine to enhance my circulation. Additionally, I have a tendency towards elevated blood pressure and am currently taking Amlodipine. My blood pressure readings have been inconsistent, occasionally spiking along with episodes of chest discomfort. While I have been cleared following an emergency room visit, the medical team emphasized the importance of discussing any changes in medication with my prescribing doctor before making any adjustments. Therefore, I seek insight on whether the combination of Midodrine and Amlodipine could be problematic, especially since my EKG, chest X-ray, and routine blood tests yielded normal results.
Answers (1)
12/14/2025, 11:00:59 PM
OpenHealth AI
Combining Midodrine and Amlodipine can have particular effects, especially considering your specific health conditions and the medications you are taking. It's great that you've had thorough evaluations and have established a care plan; however, I'll provide some guidance on their combined use.
Explanation
Midodrine is typically used to treat low blood pressure and works by constricting blood vessels, which raises blood pressure. On the other hand, Amlodipine is a calcium channel blocker that lowers blood pressure by relaxing blood vessels, making it easier for your heart to pump.
Because both medications influence blood pressure but in opposite ways, combining them can lead to unpredictable blood pressure changes. This might explain the inconsistency in your readings and episodes of chest discomfort. Given your background of Dysautonomia and hypermobile Ehlers-Danlos Syndrome (HEDS), it is crucial to manage both your blood pressure and overall vascular health carefully.
Next Steps
-
Monitor Blood Pressure Regularly: Keep a daily log of your blood pressure readings at the same times each day to identify any patterns or abnormalities. Note how you feel during these readings, especially in relation to episodes of discomfort.
-
Assess Symptoms: Track any episodes of chest discomfort and note what you were doing when they occurred, as well as their duration and intensity. This information can help clarify any potential triggers.
-
Maintain Open Communication with Healthcare Providers: Continue consulting regularly with your prescribing doctor, especially regarding the effects of these medications on your blood pressure. Discuss your findings from monitoring your blood pressure and symptoms to allow for an informed adjustment if necessary.
-
Lifestyle Considerations: Ensure you are staying well-hydrated and consider moderating salt intake, as this can impact blood pressure. Implement relaxation techniques that may help manage stress related to your BPD, as stress can also affect heart rate and blood pressure.
-
Consider a Medication Review: If you continue experiencing fluctuations, request a medication review with your healthcare team to discuss the appropriateness of continuing both medications and any alternative options.
It's commendable that you are proactive about your health. Always prioritize discussing concerns and changes with your healthcare provider, as they can give you the most tailored advice based on your specific situation. Let me know if you have further questions!
Related Questions
Seeking Insights on Oral Symptoms
I’m reaching out to see if anyone has faced a similar predicament and might have found some solutions. My mother has struggled with persistent oral issues for several years, visiting numerous doctors and allergy specialists without any tangible results, leaving her on the verge of giving up. At 55 years old, weighing 130 pounds, she is currently on medication for anxiety and thyroid conditions. Additionally, she is a non-smoker and has been diagnosed with Hashimoto's disease. Her troubling symptoms include: - Bumps and blisters on the inside of her lip, distinct from canker sores. - A noticeable knot on her tongue. These symptoms seem to be a constant presence in her life, but they intensify with the consumption of acidic foods and sugars. Despite her attempts to steer clear of acidic items and adopt a gluten-free and lactose-free lifestyle—along with cutting out starches and focusing on whole, unprocessed foods—she hasn’t experienced any relief. Tests from the allergist indicate that allergies are not contributing to her discomfort, which makes the situation even more frustrating. As it stands, she has essentially eliminated most of the foods she once enjoyed because eating has become so painful, leading to times when she simply doesn’t eat at all. Although I realize this may seem like a long shot, if anyone has encountered a similar experience, my mother is open to trying practically anything at this stage to find some respite.
Persistent Muffled Sensation in Left Ear
I'm 18 years old and for over a year now, I've experienced a peculiar sensation in my left ear, akin to being submerged in water. Alongside this unwelcome feeling, I’ve had occasional mild pressure and persistent tinnitus affecting both ears. Interestingly, whenever I manipulate my jaw, similar to a motion made to relieve ear pressure, I hear a crackling or squishing noise. About a year ago, I consulted with an ear, nose, and throat specialist regarding the tinnitus. At that time, they confirmed there was no wax blockage and my overall hearing was normal. Recently, I woke up to notice a new symptom; whenever I shift my jaw to the right, there's a distinct wooshing sound. I have a medical appointment scheduled for February, yet I’m contemplating whether I should reschedule for an earlier date due to the worsening of my symptoms. Although I am slightly concerned about the potential of an ear infection, the absence of significant pain leaves me uncertain. Could this simply be indicative of TMJ issues? Should I consider advancing my appointment?
Concern About Potential Infection in Leg Scrape
I recently scraped my leg, applied some ointment, and wrapped it with a bandage. However, I’m starting to feel anxious about the redness surrounding the injury. Initially, there wasn’t any pain while the bandage was in place, but now it has started to sting a bit since I attempted to let it dry out in the open air. I’m worried this might indicate an infection or other complications.
Experiencing Early Ejaculation: Seeking Answers
**Profile Information** **Age**: 21 **Gender**: Male **Height**: 5’8" **Weight**: 55 kg **Ethnicity**: Black **Duration of Symptoms**: 2 months **Region**: Europe **Medical Background**: No relevant health issues **Medications**: None **Message**: I have been in a relationship with my girlfriend for around seven months, and we’ve been intimate for a significant part of that time. Initially, I was able to last about 20-30 minutes during intercourse. However, I’ve noticed a gradual decline in my stamina, and recently, my duration has dwindled to approximately three minutes. I'm concerned about what might be causing this. Anyone have insights? 😢
Persistent Discomfort After Nexplanon Extraction
It's been four months since my Nexplanon was taken out, and I'm still facing discomfort and itchiness. I had the device for merely a month before deciding on its removal. Tomorrow, I have an appointment with my obstetrician. Although my primary care physician was responsible for both inserting and removing the Nexplanon, I am questioning whether I should inform my obstetrician about the ongoing pain. My PCP seems indifferent when I mention the significant pain in my arm – even light contact triggers a discomfort level of around a 5. However, if I scratch the area where the device was previously located, the pain escalates to a 7. I'm feeling quite lost; is lingering pain this long a common experience after the removal?