OpenHealth Q&A

Get answered by medical professionals

Seeking Clarity on Health Symptoms

9/13/2025, 3:50:15 PMMale25-34

From what I gather, the presence of clefted lymphoblasts is abnormal, potentially signaling either a lymphatic cancer like lymphoma or a serious infectious condition. Out of concern for my health, I conducted a Fine Needle Aspiration (FNA) on my lymph nodes, having experienced a prolonged period of illness that drove me to contemplate suicide due to my deteriorating condition. My analysis indicated that over 90% of the cells within my lymphatic tissues are lymphoblasts, which, based on my knowledge, does not align with typical infection markers. This finding has remained unchanged for a duration exceeding a year. Additionally, I've consistently shown type III Downey cells in my peripheral blood for the past two years. Despite this, tests for Epstein-Barr Virus (EBV) viral capsid came back negative, as did screenings for sexually transmitted diseases including HIV and hepatitis. My immunoglobulin levels—IgG, IgM, and IgA—are within normal ranges, and there’s no evidence of autoimmune disorders or infections. Although a monospot test indicates a possible acute infection, the persistent presence of Downey cells contradicts that notion, especially considering I haven’t engaged in any close physical contact with others for several years. Furthermore, I tested negative for chronic reactivated Epstein-Barr virus. A recent CT scan revealed that my lymph nodes have remained relatively small, measuring just a few millimeters, which I've been told is typical for an acute infection—but this seems contradictory given the duration. My lymph nodes appear to fall within a non-enlarged category, which raises relevant questions about my condition. I am seeking insight from a medical expert regarding my situation and any potential differential diagnoses. For the better part of two years, I've been dealing with flu-like symptoms incessantly, accompanied by devastating chest pain, severe cognitive issues, and an alarming decline in mental clarity.

LupusCrohn's DiseaseRheumatology

Answers (1)

Cony

9/13/2025, 3:50:36 PM

OpenHealth AI

It’s important to first acknowledge the distress and complexity of your situation. Your prolonged health issues, combined with feelings of despair, highlight how critical it is to address both your physical symptoms and your emotional wellbeing. Let's focus on clarifying your symptoms and potential next steps based on the information you provided.

Main Points:

  • The presence of clefted lymphoblasts and Downey cells can be concerning, but their implications can vary.
  • Your symptoms, alongside negative tests for major infections and autoimmune disorders, complicate the diagnosis.
  • It’s crucial to monitor your health while addressing both physical symptoms and mental health concerns.

Explanation: Clefted lymphoblasts and Downey cells are atypical findings often associated with immune responses, including infections or malignancies, but their presence does not automatically indicate a serious disease. The fact that your lymph nodes have been relatively stable and non-enlarged over time might suggest a more chronic process rather than an acute illness. The normal levels of immunoglobulins and negative results for major infections are reassuring, but your lasting symptoms require close evaluation.

Flu-like symptoms and chest pain accompanied by cognitive issues can stem from various causes, including chronic fatigue syndrome or other underlying conditions related to immune dysfunction. It's also essential to consider that psychological factors can contribute significantly to physical symptoms, especially during prolonged illness.

Specific Next Steps:

  1. Symptom Management: Focus on managing your symptoms. For chest pain, ensure you are avoiding activities that provoke discomfort. For cognitive issues, consider implementing routines that promote mental clarity, like structured rest periods and cognitive exercises.

  2. Support Network: Reach out to a trusted friend or family member about your feelings. Connecting with someone can be a crucial step. It might also be beneficial to look into mental health support options, such as therapy, to help navigate feelings of despair.

  3. Follow-Up Testing: Keep a close eye on your symptoms and consider discussing with your healthcare provider the possibility of further tests to explore other causes, including less common infections or conditions that may not have been considered yet.

  4. Keep a Symptom Diary: Monitor your symptoms daily, noting activity levels, emotional wellbeing, and any changes. This can help in appointments with healthcare professionals and may provide insights into trigger factors or patterns.

  5. Lifestyle Choices: Prioritize hydration, nutrition, and regular gentle activity, as these can support immune function and overall health. Stress management techniques, such as mindfulness or light exercise, can also be beneficial.

If at any point you feel overwhelmed or have thoughts of self-harm, please reach out to mental health professionals immediately. You don’t need to navigate this alone, and there are people who can and want to help you through this difficult time.

Related Questions

Are My Symptoms Indicating an Impending Stroke?

I’m a young adult female, weighing 99 pounds and standing 5 feet 2 inches tall. I do not smoke, vape, or consume alcohol, and currently, I am undergoing tests for POTS and HEDS. For the past two weeks, I have been experiencing intermittent discomfort in the upper region of my head, particularly in the back and temples. These aren’t typical headaches, but rather sudden twinges of pain that occur sporadically throughout the day. Additionally, over this same period, I have been dealing with bouts of vertigo—probably about 4 to 5 days where it came and went. A few days back, I also encountered a tingling sensation in my arms, which I can’t tell if it was simply due to anxiety. Given that my aunt suffered a stroke in her thirties, the prospect of having a stroke terrifies me. I find that the emergency room here primarily prescribes pain medication if you mention head discomfort, which leaves me uncertain about what steps to take next. Could these symptoms signal an impending stroke? Furthermore, I've also been experiencing pain in my left leg, though I’m unsure if that’s connected to my other symptoms.

LupusCrohn's DiseaseCOPD
Male25-34
3 minutes ago

Seeking Clarity on a Pediatric Surgical Experience

One of my earliest recollections involves surgical gauze wrapped around my genitals and being cautioned to exercise caution regarding my circumcision. This incident dates back to around 1972, when I was roughly three years old. My brother, who was eleven at the time, corroborates this memory and recalls that the bandage remained in place for "a few weeks." His recollection is a bit unclear, but he does remember seeing me running around without pants and with a gauze dressing. He believes the dressing wasn't overly bulky and doesn't recall any stent being used. However, I am aware that his memory may not be completely accurate based on other conversations we've had. He recalls being informed that I underwent surgery for an undescended testicle, yet was never made aware of a circumcision being involved. Later, a physician indirectly confirmed that I had undergone an early orchidopexy. This memory piques my curiosity, particularly since my parents have never brought it up with me. I have knowledge of having glanular/coronal hypospadias, and the details of my situation appear to align with images I’ve encountered depicting partial hypospadias corrections. This leads me to wonder if my circumcision might have actually been related to hypospadias surgery. Unfortunately, any tangible proof of these events was lost when I underwent gender confirmation surgery as a trans woman three decades ago. It's conceivable that the standard circumcision procedure typically performed at birth could have been postponed, given that I was born slightly premature and had significant Rh disease and hypoxia. But could it have been deferred until I reached the age of three? I have made attempts to obtain my medical records, but unfortunately, they have been destroyed over the years. While I understand that definitive answers may be elusive, I would greatly appreciate any insights or thoughts on this matter.

ArthritisCrohn's DiseaseRheumatology
Male25-34
1 hour ago

Concerns About Potential Peripheral Artery Disease (PAD)

For the past three to four years, I have been dealing with a persistent numbness in my left foot. Initially, I suspected it might be due to a pinched nerve or perhaps something similar, but the sensation has never completely returned. As time has gone by, I've encountered additional worrying symptoms: - My feet have started to develop a purple hue, particularly evident when I sit in positions that put pressure on my legs or when I take a shower. This discoloration has become one of the most alarming signs of my condition. - The growth of my toenails has slowed considerably, and they now appear uneven and ridged. - Additionally, my feet have a temperature that feels significantly colder than the rest of my body, and they no longer grow hair as they once did. I do not smoke and I’m not diabetic; however, I have high cholesterol and received an elevated result on a lipoprotein test. The prospect of PAD is frightening to me, as it seems synonymous with a grim future. I have been referred to a cardiologist, but they are reluctant to conduct an Ankle-Brachial Index (ABI) test since I am under 35. I want to remain hopeful and believe I don't have PAD, yet I struggle to identify any other plausible explanations for these symptoms. What could be potential alternatives to consider, if any exist?

FibromyalgiaCrohn's DiseaseThyroid Disorders
Male25-34
1 hour ago

Unexplained Left Chest Pain, Electric-Like Jabs in Lower Back, and Unusual Headaches

Hi there, I’m a 15-year-old experiencing some peculiar health issues lately. A visit to my doctor led to a diagnosis of anxiety and poor posture after I complained about headaches and strange, electric sensations rising through my head. However, after that appointment, I became aware of pain in my heart and strange discomfort in my left chest accompanied by difficulty breathing. Initially, I thought these symptoms aligned with anxiety, but they persisted long enough to cause concern. To rule out any serious conditions, I underwent a blood test, which fortunately came back normal. Despite the positive results, I continued to feel unusual pains in my heart region and a peculiar ache in my lower abdomen. The doctor had previously mentioned my poor posture and identified an issue with my occipital nerve, which I’ve somewhat addressed. Now, though, I find myself having intermittent back pain and brief discomfort just beneath my left lung. These pains are indeed strange; they don’t always last long, sometimes just fading after five seconds or they might stick around for several minutes. I tend to spend a lot of time in bed and don’t often leave the house, yet when I do, these pains still occur. Thankfully, they aren’t debilitating, but I can't help but feel anxious thinking something might be significantly wrong with my health. It’s unsettling and I’d prefer not to dwell on such thoughts. To summarize: I experience chest pain in my lower left quadrant, specifically near my lung, alongside a mild but uncomfortable sensation that waxes and wanes. Additionally, I suffer from headaches located on the upper left side of my head. I apologize for any grammatical errors as I used voice-to-text for this message. Another detail that might be relevant is that I have recently quit vaping, now almost 22 days ago, and I wonder if this could be part of the recovery process.

LupusThyroid DisordersInternal Medicine
Male25-34
1 hour ago

Concerns About Potential Misdiagnosis

Hello everyone, I recently stumbled upon this subreddit and felt it would be the ideal platform to share my experience. I initially posted something similar under r/Asthma but soon realized that this community might be more appropriate for my concerns. To provide some context, I’m a 25-year-old woman with no personal history of smoking, although I have been heavily exposed to secondhand smoke throughout my life. There is a family history of asthma and COPD on my side. I was diagnosed with asthma during childhood but seemed to outgrow it as I got older. Throughout my younger years, I frequently battled respiratory and sinus infections, and in my teenage years, I suffered a severe case of walking pneumonia. Following that episode, my breathing worsened significantly, prompting my doctor to reinstate the asthma diagnosis and prescribe albuterol inhalers without performing any additional tests except for an X-ray to confirm the pneumonia had resolved. Over the years, I’ve noticed a gradual worsening of my symptoms. Each primary care physician I've consulted has prescribed various inhalers and medications, but the relief they provide has been minimal. For years, I have dealt with a persistent dry cough described as that of a seasoned smoker, yet my doctors continuously assured me it was merely asthma, claiming that my inhalers would alleviate it. When a coughing fit does occur, it can be so intense that I end up gagging, losing control of my bladder, and feeling dizzy. Fast forward to two weeks ago: my cough intensifies with physical activity, and I have a physically demanding job. Typically, my inhaler assists me with breathing, but in this instance, it was ineffective, and emergency services were called to administer oxygen. My oxygen saturation dropped to 93% until the oxygen and my rescue inhaler were applied. I declined hospitalization after feeling better with the oxygen. I took a day off work to recuperate. I managed to see my primary care doctor afterward. Having been on Advair and albuterol for years, I was also prescribed Singulair last year due to flare-ups. In my recent visit, my doctor substituted my Ventolin (albuterol) with Airsupra and introduced Spiriva, along with short courses of Mucinex and Prednisone. At the appointment, my lungs sounded clear, and my oxygen levels were between 99-100%. There was no wheezing, just persistent coughing. Returning to work the following Thursday proved challenging; within three hours, I experienced another severe coughing episode that felt as if my throat might rupture. I was gagging, tearing up, and struggling to remain upright, feeling dizzy and breathless. Several doses of my rescue inhaler provided little relief, and emergency services were contacted again; I was subsequently transported to the emergency room. My oxygen saturation was stable at 97-100%, yet I continued to feel breathless and my painful coughing persisted. Respiratory treatments seemed to exacerbate the coughing, and magnesium failed to provide relief. Both the paramedics and ER staff expressed concern when I mentioned my chronic cough that had persisted for years without improvement. Initially, emergency responders detected only a faint wheeze and diminished lung sounds on one side, although they later reported normal findings. No fluid or wheezing was noted, just continued coughing. CT scans and X-rays of my throat and chest returned normal results. After three days in the hospital, my lactic acid and CO2 levels returned to normal. Despite being treated with steroids and cough suppressants, I found no alleviation of my symptoms. I have now received urgent referrals to a pulmonologist, an ENT specialist, and an allergist, and I recently followed up with my primary care physician. Her only recommendation was cough drops and to wait for my upcoming Pulmonary Function Test (PFT). Additionally, the hospital prescribed Pantoprazole for potential GERD, which hasn't significantly helped. My follow-up blood tests revealed that while my CO2 levels improved, they still remain low, and there are no current indications of an autoimmune disorder, though I am awaiting several results. After undergoing the Pulmonary Function Test, the findings were unusual. Though I await an appointment with the pulmonologist, I reviewed the notes from my test. They indicated, "Spirometry is normal. Lung volumes demonstrate hyperinflation and air trapping. Diffusing capacity is normal. No substantial bronchodilator response observed." When I inquired with the technician who administered the test, she mentioned two possibilities: either my lungs weren't inflamed enough to demonstrate a response, which seemed unlikely considering my extensive coughing fits, or the underlying issue might be irreparable with medications. This situation has left me anxious that I may be dealing with more than just severe asthma. For years, I communicated to my doctors that my condition seems to deteriorate, and that none of the prescribed medications eased my cough, yet they continuously reassured me that it was manageable. Now, after being hospitalized, I recognize the critical need to take this seriously. I rarely experience wheezing or fluid but instead contend with a persistent cough similar to that of a long-term smoker. My cough worsens with movement, eating, drinking, taking deep breaths, lying down, waking up, laughing, excessive talking, exposure to extreme temperatures, dry or humid air, stress, and irritants such as dust, smoke, and potent odors. It feels like merely existing prompts my coughing. Although I always have a cough, the triggers mentioned intensify it. I frequently feel congestion in my throat and chest, accompanied by a tight and painful sensation. I have the incessant urge to clear out whatever feels obstructive, but nothing ever emerges. My coughing often leads to dizziness and incontinence. If I'm not actively coughing, I seem to be clearing my throat repeatedly to manage the mucus. During any illness, my cough tends to worsen, resulting in the need for prednisone. Antihistamines provide partial relief solely for nasal symptoms, without helping my throat and chest. When my rescue inhaler does work, its effectiveness lasts only for a short time before I revert to my previous condition. My lungs may feel momentarily unobstructed thanks to the albuterol, but the coughing inevitably returns until my chest aches again. An ER doctor suggested possible diagnoses of Chronic Rhinosinusitis, Post-Nasal Drip, or GERD; however, medications for allergies and acid reflux have not meaningfully addressed my coughing or breathlessness. It does not seem connected to my sinuses but rather feels like my airways are obstructed, hindering deep breaths. Until I meet with the pulmonologist, my best hypothesis has been Cough-Variant Asthma, but given the lack of response to bronchodilators in my PFT, my confidence in that is wavering. In reviewing my results, I cannot help but consider the early stages of COPD or emphysema, especially since my breathing seems to worsen over time, although my age typically mitigates those concerns given my extensive exposure. I've ordered a test for Alpha-1 antitrypsin deficiency from AlphaID to discuss with my pulmonologist just in case. I am certain I have asthma, but I’m beginning to suspect that there may be additional complications involved. For years, my primary care provider dismissed my concerns, despite my insistence that something felt off. It wasn’t until I required EMS intervention that she finally began the referral process to specialists. I find myself in a state of confusion and unease. Has anyone here experienced anything resembling my situation? I'm looking forward to consulting with the pulmonologist about my test results in the coming week or two, but I’m apprehensive that they will simply dismiss my concerns like previous practitioners have done.

AsthmaCrohn's DiseaseCOPD
Male25-34
2 hours ago