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Does My Body Build Resistance to Medications?

8/22/2025, 10:11:59 PMMale25-34

The title captures my experience accurately, though it warrants further elaboration. As a young man in my twenties, I've encountered various health challenges, including conditions like acne and psoriasis. What I’ve noticed is a concerning trend: I seem to develop a tolerance to every medication I try, eventually rendering them ineffective. Take benzoyl peroxide, for instance; it is widely recognized as a highly effective acne treatment. Initially, it worked for me, but over time, I began to experience swelling, and soon after, it ceased to have any effect. This shift occurred after many months of consistent use of various prescriptions. A couple of years down the line, I was put on antibiotics to tackle my facial acne. However, to my disappointment, the result was negligible—if anything, my condition either worsened or remained unchanged. During my college days, I realized I was developing psoriasis, which I initially mistook for simple dandruff. After ineffective attempts with over-the-counter shampoos like Head & Shoulders, I decided to consult a general practitioner. I received a steroid treatment for my scalp that worked wonders at first, providing immediate relief. Each time my psoriasis flared up, I reapplied it, and it swiftly cleared up again. Yet here I am, a year later, facing increasing severity in my psoriasis, and that same topical solution no longer brings the same results—its effectiveness has significantly diminished.

LupusFibromyalgiaInternal Medicine

Answers (1)

Cony

8/22/2025, 10:12:19 PM

OpenHealth AI

It sounds like you're experiencing a frustrating pattern with medications, often referred to as "tolerance," where your body doesn't respond as well over time. This can happen with some treatments, especially in the context of chronic skin conditions like acne and psoriasis.

Understanding Medication Tolerance

  • Benzoyl Peroxide: Initially effective for acne, but consistent use may lead to irritation or reduced benefit over time. This can occur as your skin adapts or if there is increased irritation.
  • Antibiotics: Your experience of antibiotic ineffectiveness can also be related to the body's adjustment, particularly in the context of skin bacteria and inflammation.
  • Topical Steroids: These may provide quick relief for psoriasis, but overuse can lead to diminishing returns, where the skin becomes less responsive and more reliant on stronger or different treatments.

Immediate Steps to Consider:

  1. Identify Triggers: Start keeping a record of your breakouts or flare-ups. Track factors such as diet, stress, environmental changes, or product use that might influence your skin condition.

  2. Review Medication Usage: Evaluate how long you've been using each medication. It may be beneficial to introduce breaks or rotate treatments under guidance, allowing your skin to reset.

  3. Explore Alternatives: Look into combining treatments (like using different classes of medications together), or consider non-medication approaches like lifestyle changes, which can impact skin health positively.

  4. Moisturizing Routine: For psoriasis, regular moisturizing can help maintain skin barrier function and reduce irritation. Use emollient creams or ointments to combat dryness between flare-ups.

  5. Consult a Specialist: While you’re seeking to manage your medications effectively, it may be beneficial to consult a dermatologist or a healthcare provider for tailored advice and to explore new, possibly more effective treatment regimens.

Final Thoughts

Many people share similar challenges with chronic skin conditions. It’s important to be patient and proactive about understanding your body’s responses to treatment. Monitoring and documenting your symptoms and triggers will empower you in discussions with healthcare professionals about finding effective solutions. If you feel comfortable, keep a symptom and treatment response diary, and share that information with your doctor during your next visit.

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