Seeking Perspectives on the Long-Term Safety of Weight Loss Medications
At the age of 42, standing at 5’4” and weighing 180 pounds, I find myself grappling with anxiety and depression for which I am currently on medication—namely Wellbutrin and Cymbalta. I've been contemplating reaching out to my primary care physician regarding options for weight loss medication. It's worth noting that I do not have diabetes. While I have managed to shed a few pounds through programs such as Weight Watchers, maintaining that weight loss has proven to be a challenge. My motivation tends to dwindle after about a month, and despite attempting to incorporate gym workouts into my routine, I absolutely loathe exercising. Lately, I've noticed that my self-esteem is increasingly affected by my weight concerns. Given all of this, I'm feeling somewhat hesitant to discuss my situation with my PCP. This leads me to wonder: Is it genuinely beneficial to pursue this path? How safe are these medications in the long term? Are the side effects as severe as some suggest? My research has presented a more optimistic view, yet it all seems almost too good to be accurate. Additionally, I question whether I qualify as a suitable candidate for these treatments since I don't fall into the category of morbid obesity. I would greatly appreciate any insights you can share on this matter.
Answers (1)

7/23/2025, 8:50:43 PM
OpenHealth AI
It's understandable to feel uncertain about pursuing weight loss medications, especially when considering their long-term safety and potential side effects. Let’s break this down:
Main Points:
- Weight Loss Medications: They can be effective, but their suitability varies based on individual circumstances.
- Long-Term Safety: Research indicates that many weight loss medications can be safe for long-term use, but they may come with side effects.
- Consultation Importance: Your primary care physician (PCP) can provide personalized advice, taking into account your overall health and any current medications.
Explanation:
Weight loss medications are designed to aid in losing weight, often in conjunction with lifestyle changes such as diet and exercise. Commonly prescribed medications can help decrease appetite or increase feelings of fullness. The long-term safety of these medications has been studied extensively, and while most are deemed safe for extended use, they can have side effects ranging from mild (like nausea or constipation) to more serious (like increased heart rate or gastrointestinal issues). It’s essential to weigh these potential risks against the benefits, especially considering your mental health and how weight impacts your self-esteem.
Next Steps:
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Reflect on Your Goals: Think about what you hope to achieve with weight loss medications and whether you believe they can support your weight loss journey.
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Prepare for Your PCP Visit: Make a list of your concerns and questions about weight loss medications, side effects, and suitability. This can help ease your anxiety about discussing it with your doctor.
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Explore Non-Medication Options: While medication can be beneficial, consider continuing to explore non-medication avenues such as:
- Finding enjoyable physical activities that can replace traditional workouts (like dancing or hiking).
- Seeking support groups or counseling for motivation and accountability.
- Reviewing nutritional adjustments with a registered dietitian who can provide tailored advice based on your preferences.
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Monitor Your Mental Health: Since you're on medications for anxiety and depression, keep your healthcare provider informed about how changes in your weight or plan to lose weight affect your mental health.
It’s commendable that you’re seeking information and considering options to manage your weight and improve your self-esteem. Remember, this is a journey, and each small step you take can lead to significant change over time. If you have more questions or need further guidance, feel free to reach out!
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