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Mixing Xanax with Benadryl

7/22/2025, 5:30:32 AMMale25-34

Approximately an hour and a half ago, I ingested 0.5 mg of Xanax, followed by a single dose of Benadryl. Now, I'm genuinely frightened; I can’t recall if I had taken the Xanax earlier and I'm unsure about the safety of combining these two medications. The fear is overwhelming, and I'm considering whether I should seek emergency medical help. I’m a 30-year-old woman weighing 140 pounds and I'm not currently on any other medications. Is there anyone who can advise me on what to do next?

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Answers (1)

Cony

7/22/2025, 5:31:00 AM

OpenHealth AI

It's understandable to feel anxious about mixing Xanax (a benzodiazepine) with Benadryl (an antihistamine), especially if you're unsure about your previous doses. Both medications can cause sedation and enhance each other’s effects, potentially leading to increased drowsiness or other side effects.

Explanation:

When combined, Xanax and Benadryl can amplify central nervous system effects, which may lead to increased sedation, confusion, or impaired coordination. Since you've recently taken both, it’s important to monitor how you're feeling. If you're feeling anxious, you're not alone—these feelings can happen in such situations.

Next Steps:

  1. Stay Calm: Try to take deep, slow breaths to reduce your anxiety. Panic can make physical symptoms feel worse.

  2. Monitor Your Symptoms: Pay attention to how you’re feeling. Look for any signs of excessive drowsiness, confusion, or difficulty breathing.

  3. Stay Hydrated: Drink water to help your body metabolize the medications more effectively.

  4. Avoid Additional Medications: Do not take any more sedatives or alcohol, as these can worsen the effects.

  5. Call for Help if Needed: If you feel excessively drowsy, confused, or experience difficulty breathing, don't hesitate to call emergency services or have someone take you to the nearest emergency room.

  6. Reassess After Some Time: If you’re feeling stable and your symptoms seem mild, continue to monitor yourself over the next few hours.

Always prioritize your safety. If your anxiety continues or worsens, it’s okay to reach out for help. It's better to err on the side of caution when it comes to your health.

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