Understanding the Connection Between Anti-Psychotics and Inflammation in PVNS
During my college years, I received a diagnosis of Pigmented Villonodular Synovitis (PVNS) affecting my left hip. This condition had troubled me since adolescence. I experienced severe flare-ups that would render me unable to bear weight on my leg, necessitating the use of a cane. Fortunately, after a week, I would regain the ability to walk without assistance or pain. These episodes persisted intermittently throughout my twenties. At the age of 29, in 2021, I was diagnosed with an unspecified form of psychosis, for which I was prescribed 2 mg of Risperidone. I consider myself fortunate, as I haven’t faced a relapse of psychotic symptoms, apart from a brief period when I abruptly stopped taking Risperidone for a few months. Since resuming my medication in 2022, I’ve not experienced any further psychotic episodes. Interestingly, I have noticed that my left hip tends to attempt flare-ups on occasion, yet they tend to resolve by the following day. What could explain this connection? I find this relationship both perplexing and intriguing.
Answers (1)
7/19/2025, 12:40:39 PM
OpenHealth AI
Your observations about the relationship between your anti-psychotic medication (Risperidone) and the flare-ups of Pigmented Villonodular Synovitis (PVNS) are indeed intriguing. Let’s explore this connection and what it might mean for your situation.
Main Points:
- Potential Interaction: While there is no direct known link between anti-psychotic medications like Risperidone and PVNS, medication can sometimes influence inflammation and pain perception.
- Inflammatory Response: Your PVNS itself is an inflammatory condition, and it's possible that fluctuations in your stress levels or overall mental health could indirectly impact its severity.
Explanation:
Risperidone is known to impact neurotransmitters in the brain, particularly dopamine and serotonin. Alterations in these neurotransmitters might influence how you perceive pain or respond to stress, which can exacerbate inflammatory conditions like PVNS. Moreover, stress can trigger inflammatory responses, potentially leading to flare-ups in conditions like yours.
The fact that your hip tends to flare-up but resolves quickly might indicate that these episodes are linked more to short-term stress or inflammation rather than a chronic worsening of your PVNS.
Next Steps:
-
Monitor Symptoms: Keep a detailed log of your hip symptoms, especially noting when flare-ups happen in relation to your mental state or stress levels. Track these patterns over time for better insights.
-
Manage Stress: Incorporate stress-reducing activities such as mindfulness, yoga, or gentle exercise. These can support both mental health and possibly help alleviate inflammation.
-
Consult with Health Professionals: While I won’t suggest seeking immediate consultations, if your hip symptoms or mental health change significantly, consider discussing these observations with your healthcare provider to explore adjustments in treatment if necessary.
-
Stay Active Safely: Ensure you are engaging in low-impact activities to keep your hip joint from becoming stiff and strengthen surrounding muscles, as tolerated.
Your experiences are valuable, and it's good to keep an eye on how different aspects of your health interact with each other. Feel free to share any patterns you notice or further questions as you continue to navigate your health journey.
Related Questions
Experiencing Widespread Muscle Weakness
I’m a 36-year-old male and have recently been facing a troubling situation where the muscles throughout my body seem to be losing function—including my eyelids. The trouble began in May 2021 when I lifted a heavy garbage can with my right arm in a shrugging action. Following that, I felt a combination of pain and weakness concentrated in my right shoulder blade, as well as my shoulder and collarbone. Soon after, I noticed my shoulder began to pop and click. Afterward, I consulted with an orthopedic specialist who conducted x-rays on both of my shoulders. He informed me that everything appeared normal and dismissed the popping sounds as inconsequential. I also mentioned experiencing neck pain, but he indicated that addressing neck issues wasn’t his area of expertise. He diagnosed me with bilateral shoulder and neck discomfort and recommended physical therapy. The day after my appointment, I attempted to adjust my position in my desk chair by leaning on the left armrest, putting my forearm under the weight of my body. Suddenly, my shoulder jolted, and I felt a sharp weakness in my arm, accompanied by popping and clicking noises, similar to what happened with my right arm. I reached out to the orthopedic office to inform them about this incident, but the physician assistant who responded said the doctor would not see me again simply due to how I was sitting, and suggested I attend physical therapy first. She mentioned that if I continued to experience weakness, a neurologist might be necessary. Feeling concerned, I returned to my primary care physician for a follow-up appointment and recounted my experience. He didn’t appear worried, and my blood tests returned normal results. During the summer of 2021, I began physical therapy where the therapist diagnosed me with strains in my trapezius and rhomboid muscles. The subsequent therapy sessions consisted of painful exercises and stretches, yet I observed little to no improvement in terms of strength or stability. Activities like using the arm bike and weight machine were excruciating, and I frequently inquired whether my symptoms could be attributed to a tear or nerve damage, but the therapist insisted that was not the case and dismissed my concerns. After my tenth session, I decided it was best not to return. In April 2022, I visited a neurologist. I struggled to lift myself onto the examination table and needed assistance from a step stool. He didn't suspect any neurological issues when I asked him about an EMG or other assessments, he declined to proceed with those tests. Disheartened by these experiences, I chose not to pursue further medical consultations. Fast forward to April 9, 2025, I misstepped while descending some stairs, causing my right heel to catch, and I landed hard with my toes pointed. I had no visible signs of injury such as swelling or bruising, but soon after, I began to experience persistent pain and weakness, especially in my toes and the arch of my foot. By April 13, I instinctively elevated the toes on my left foot, and to my dismay, the same pain and weakness emerged, again without any visible signs like bruising. Since then, both feet have lacked strength, and my big toes feel unusually floppy. In July 2025, I had a troubling experience after having my hair washed at a salon. I held my neck in an awkward position for the duration, which resulted in a burning sensation. Regrettably, I didn’t express my discomfort, fearing a scene. Following this, I noticed significant weakness in the muscles at the front of my neck, under my chin, which gave the appearance of a receding chin. Additionally, my facial muscles, particularly in my cheeks, felt weak and could easily be pressed in with minimal resistance. In January 2026, I bought a new game controller for my laptop, having not played video games for a long time. Initially, it was manageable, but soon after, my hands and forearms began to feel uncomfortable and painful. This discomfort escalated significantly to where I had to discontinue use completely; my hands felt drained of energy and experienced achiness, tingling, and numbness. Then, on February 3, 2026, while seated and using my laptop, I noticed a peculiar sensation when moving my eyes. My eyelid muscles felt weak, and one of my eyelids began twitching. I found it increasingly difficult to open my eyes as widely as I used to. I plan to see a primary care physician once more, but I’m uncertain how to communicate all of this effectively to receive proper care. My circumstances have reached a point where my parents must assist me with everyday tasks, including driving, opening doors, and even lifting light objects. My ability to raise my arms above my head has become severely limited as well.
Concerns Regarding Neurological Health
Hello! I received an epilepsy diagnosis back in 2008, and throughout this time, various MRI and CT imaging studies have indicated issues related to cerebral function and encephalopathy. Despite consulting multiple neurologists over the years, I’ve found that none of them appear worried about the encephalopathy aspect. Shouldn’t this be something to take more seriously? My cognitive abilities, including memory and vision, have noticeably deteriorated as time has passed. I’m feeling lost since my previous neurologists have not acknowledged my concerns adequately. If anyone could offer guidance or suggest resources, I would greatly appreciate it. In addition to epilepsy, my other medical conditions include Narcolepsy, Lynch Syndrome, Migraines, a mutation associated with HLA-B27, and Hashimoto's disease, along with others that escape me for the moment. Currently, I’m on a medication regimen that includes Lamictal, Xcopri, Hydroxyzine, Solifenacin, Zoloft, Wellbutrin, Sunosi, Aimovig, and Famotidine.
Understanding My Experience with Overdose-Related Symptoms and Behavior
25 years old, 165 cm tall, and weighing 70 kg. Summary: After sharing a complaint about my interactions with paramedics, I've taken a moment to reflect on their feedback and review the situation through the footage. I recognize that my conduct during those moments was inappropriate, and I am filled with remorse. Subsequently, I have retracted my complaint and am now seeking mental health support. I desire to clarify certain aspects since my medical records do not completely align with what I went through. Below, I detail my symptoms. Yesterday, I made a post on the AskDoctors forum, hoping for insights regarding my condition. The advice I received prompted a self-realization that had evaded me until now. Initially, I was outlining a grievance against paramedics who doubted the legitimacy of my seizures and accused me of feigning the experience. My response was not only disproportionate but also hostile—I yelled, wept, and labeled them as heartless. Such reactions were completely unwarranted and unjustifiable. Ultimately, I was physically stable, with vital signs indicating no critical issues; there were only temporary fluctuations in my blood work, which shouldn’t have raised alarms. I feel profound regret over my conduct during that encounter. Watching the footage incites feelings of self-disgust. I’ve decided to withdraw my complaints and am committed to mental health resources. I opted to delete my previous post since it contained sensitive information about my professional and educational background; I was worried it might provoke disciplinary action from my university, which I cherish as my career gives my life meaning. I admit to feeling cowardly in this respect. The initial reason for my inquiry was a desperate need for clarity about the symptoms I experienced, as my discharge documentation omits much of what transpired in the hospital and the subsequent three days. I greatly value the input I’ve received and hope to gather more perspectives. I fully acknowledge my wrongdoings and find my previous behavior abhorrent. I understand how challenging it is for emergency personnel to fulfill their duties when faced with such a situation. I’ve discussed with family and friends the importance of exercising discretion when contacting emergency services and ensuring it’s truly necessary. I regret taking up valuable resources that could have been reserved for individuals in genuine need of urgent care. My actions were shameful, not just for me but also for my colleagues who work in emergency services; I genuinely believe the clinicians should have distanced themselves from my case entirely. I've canceled my appointment with the neurologist, but I would genuinely appreciate insights from others on this subject. Could excessive doses of sertraline, propranolol, promethazine, and alcohol induce psychological seizures? Is it possible for these seizures to recur? Were my hallucinations indicative of some kind of psychosis? During the episodes, I saw hair-like formations everywhere and everything seemed to emit a blue glow. In the hospital, I consistently perceived doctors passing by. At home, the LED lights appeared to move, and I often caught glimpses of faces in my peripheral vision. There were also auditory experiences, such as hearing things that weren’t present, as confirmed by my friend. Initially at home, I was unaware I was having seizures, although I did hear police officers numbering them and acknowledging them as such. I had three episodes where I was placed in the recovery position. In my medical notes, I mentioned experiencing ten seizures throughout the night, though I can’t verify this. I was seemingly in a continuous cycle of them. I recall at least once drooling uncontrollably and my hands looked peculiar; on one occasion, I screamed when I regained consciousness due to an awkward hand position. I also experienced significant neck pain and discomfort in my feet. I know I fell twice while hospitalized; fortunately, my mother was there to catch me each time, so I avoided serious injury. I was never alone in the facility. Everything seemed to settle down after approximately three days, right around my third visit. I recall a persistent ache at the nape of my neck that left me feeling drowsy, often drifting in and out of consciousness and repeatedly asking for the time. It was a never-ending ordeal, and although I had little appetite, I did not vomit at all. Reflecting on this whole episode leaves me feeling as if it were entirely fabricated. I struggle to articulate it. Conversations about care options unfolded around me, yet I grasped little of what was being discussed. I often replied with “yes” or sought validation from my mother. I remember thinking it was remarkable that my mum had glasses with water in them; I even imagined one of my cats perched on my aunt’s shoulder. Overall, it felt akin to a terrifying drug experience. I do have videos capturing my behavior at home, though I cannot recall anything from the hospital. I often awakened with either my mother, aunt, or medical staff restraining me. Could it all stem from psychological causes? Is it possible that the medications led to a psychotic episode where I convinced myself I was experiencing seizures and on the brink of death? After they subsided, I felt like an automaton for weeks, plagued by involuntary muscle jerks—primarily in my legs and neck. I sincerely hope these symptoms do not return. I intend to avoid emergency care unless it’s absolutely necessary. I seek nothing more than to comprehend what transpired. Thank you for your thoughts.
A Mysterious Illness That Resembles Strep Throat
As an 18-year-old college student, standing at 5'4" and weighing 140 pounds, I maintain an active lifestyle. I do not smoke or have any preexisting health issues, aside from the vitamins and supplements I take daily. Approximately five days ago, I began to feel unusually fatigued and achy. Within just a day, my symptoms escalated to include a high fever reaching between 101°F and 102°F that ibuprofen couldn’t seem to alleviate. I experienced extreme tiredness that kept me bedridden all day, along with a persistent headache and intense throat pain, which was compounded by swollen lymph nodes and the familiar white patches often associated with strep throat. Having dealt with strep throat before, I recognized a need for antibiotics. Two days into feeling unwell, I visited an urgent care facility for an assessment and received a rapid strep test, which unfortunately came back negative. I recalled a previous incident where my rapid strep test also indicated a false negative, only for the culture sent for further testing to confirm the presence of strep bacteria. Given my symptoms and the findings from the examination, the healthcare provider prescribed Cefdinir, as I am allergic to amoxicillin, despite the negative rapid test results. The antibiotics proved effective, and I felt nearly back to normal, leading me to believe that my culture results would also come back positive for strep, suggesting a recurrence of my previous infection. However, I received the culture results yesterday, and to my surprise, they came back negative for strep. While I lack medical expertise, I’ve been led to believe that false negatives in cultures are exceedingly rare. Now, I find myself puzzled about what kind of bacterial infection I might have had if it wasn’t strep. Any insights or information regarding my situation would be greatly appreciated. Thank you!
Understanding Recurrent Symptoms: Are They Histamine-Related?
Hello, health professionals, I am seeking your expertise regarding a variety of symptoms I have been experiencing intermittently over the years. While they appear linked, I'm having difficulty pinpointing their root cause. **Personal Summary:** - 27 years old, Female - Non-smoker (formerly vaped for about eight years, cessation initiated two years ago) - No diagnosed autoimmune conditions - Background of anxiety (which might exacerbate some symptoms, though it doesn't account for all) - Currently taking Flonase and a multivitamin **Skin Reactions:** - I've dealt with recurring itchy rashes and hive-like bumps since childhood. They manifest suddenly and usually resolve without intervention. - These rashes are often itchy, can be raised, and tend to appear sporadically without identifiable triggers. - Antihistamines provide consistent relief, leading me to suspect a role of histamines in these eruptions. - These episodes do not align with typical contact allergies or classic food allergies. - They can happen multiple times daily, and I've often dismissed them as merely anxiety-related rashes. - Sometimes the itching precedes the visible rash, while other instances present with a red, inflamed area that stirs inquiries about my well-being from others. **Foot Discomfort:** - Over the last few years, I’ve encountered severe itching on the soles of my feet. - These episodes typically include small pale or white spots with redness surrounding them, occasionally featuring a red center. - Itching intensity can be overwhelming, yet these lesions usually arise suddenly, - They frequently improve upon avoiding scratching and may resolve within a range of 30 minutes to two days. - The first episode was triggered after swimming in a freshwater lake, though I’ve also experienced it while wearing specific footwear like Crocs or boots, but not consistently. - Certain events coincide with my typical skin rash, hinting at a potential systemic condition rather than merely a localized issue. - The symptoms do not mirror those of warts, ringworm, or fungal infections. **Ear and Sinus Issues:** - Itchy ears have been a recurring issue for the past few years; I initially attributed it to overly aggressive cleaning with cotton swabs, which I realize is harmful. - I have a history of chronic sinus problems, including post-nasal drip and regular ear infections. - The inflammation appears to flare up sporadically rather than constantly. - Recently, I experienced a painful ear issue that began with what I thought was a pimple. The next day, my ear was swollen. After visiting a clinic, I was diagnosed with a double ear and sinus infection, treated with antibiotics. My pain persisted, leading to a follow-up with my primary care physician, who prescribed Flonase and noted ongoing nasal inflammation. Missing doses led to increased ear discomfort, prompting me to take Flonase more regularly. Unfortunately, a recent flare of swelling and discomfort in my ear led me to consider consulting an ENT specialist. **Gastrointestinal Symptoms:** - I was diagnosed with gastritis through an upper endoscopy procedure. - Testing for H. pylori returned negative. - I've since developed food sensitivities and gastrointestinal discomfort not previously experienced. - I saw significant improvement after removing gluten and dairy from my diet, with tests for celiac disease yielding negative results. - Symptoms tend to flare up in response to stress or specific food intake rather than being a constant presence. **Additional Context:** - A history of childhood asthma (now occurs infrequently) - Sensitivity to heat - Past instances of feeling lightheaded, resembling vasovagal symptoms, alongside vertigo - Symptoms across various systems often flare together, but not in every instance - While my anxiety can intensify symptoms, both antihistamines and diet modifications have had notable positive effects **My Inquiry:** While I don’t wish to self-diagnose, I'm curious if my range of symptoms might suggest: - Histamine intolerance - Mast-cell overactivity (not necessarily MCAS, but an increased reaction) - Physical or contact urticaria I'm primarily seeking: - Recommendations for a suitable specialist - Insight on whether this symptom pattern fits a recognized mechanism - A clearer understanding of what warning signs to be concerned about **Summary:** I contend with a long-standing pattern of episodic itchy rashes and hives, significant but transient foot itching along with bumps, persistent ear irritation coupled with sinus problems, and gastritis accompanied by food sensitivities that improved on an elimination diet. Antihistamines aid multiple symptoms. Could this suggest underlying histamine-related issues manifesting across multiple systems rather than in isolation?