OpenHealth Q&A

Get answered by medical professionals

Understanding Persistent Swelling of Lymph Nodes and Severe Fatigue: How Concerned Should I Be?

7/1/2025, 6:30:50 PMMale25-34

I am a 26-year-old woman, standing at 5’3” and weighing 180 pounds. I have a medical history that includes rheumatoid arthritis, migraines, autism, and ADHD. As I await my follow-up appointments, I seek insight regarding a health issue. For over six weeks, I have been experiencing a consistently swollen lymph node located under my jaw, on the right side. It is firm and uncomfortable, although not severely painful. Recently, I have also noticed swelling behind my right jaw joint, accompanied by pressure sensations affecting my ear. While there are no drainage issues or alterations in my hearing, I do experience discomfort along with a sensation of fullness. This swelling becomes more pronounced while breathing and swallowing, and I find myself having occasional coughing fits, coupled with difficulty in catching my breath. Additionally, I am grappling with severe fatigue that has intensified over time, despite getting adequate sleep. This unfortunately is the most debilitating fatigue I have ever encountered, which is particularly significant given my existing autoimmune conditions. I am not experiencing fever, recent infections, or night sweats. Alarmingly, I have unintentionally lost a considerable amount of weight—approximately 85-100 pounds over the past eight to twelve months, without actively trying to shed any pounds. Recent blood tests indicated an increase in lymphocytes, but my ESR and CRP levels remained within normal ranges. I have a CT scan scheduled but have not undergone it yet. Two weeks ago, I had an ultrasound that revealed no remarkable findings, although the technician seemed confused about my description of a lump. I find myself wondering about how serious my condition might be in the interim. Should I be worried that this could signal something urgent, such as lymphoma or an abscess, or is it likely that it’s a benign and slow-progressing issue? My discomfort is impacting my ability to work, as I am canceling clients due to overwhelming exhaustion, and I feel generally unwell—my symptoms are worsening. Notably, one side of my neck and face appears visibly swollen, and I can barely detect a pulse on that side due to the extent of the swelling. I appreciate any guidance you can offer. Today has been particularly difficult, and while my wife urges me to seek emergency care, I am unsure whether the situation warrants it. I have another appointment with my doctor in a week; do you think that will suffice?

LupusCOPDRheumatology

Answers (1)

Cony

7/1/2025, 6:31:12 PM

OpenHealth AI

It's understandable to be concerned about persistent lymph node swelling and severe fatigue, especially given your medical history. You are right to seek clarification while awaiting further medical evaluation. Here's a structured approach to your situation:

Key Points

  1. Swollen Lymph Node & Fatigue: Your symptoms of a firm, swollen lymph node and significant fatigue warrant close monitoring, particularly as they have persisted for more than six weeks.
  2. Weight Loss & Other Symptoms: The notable weight loss and the discomfort you're experiencing suggest a potentially serious underlying issue that deserves attention.
  3. Need for Further Evaluation: While waiting for your CT scan, it’s crucial to assess whether your symptoms are worsening.

Explanation

Swollen lymph nodes can arise from various causes, including infections, inflammation, or even malignancies. Given your description of other symptoms—pressure sensations, difficulty breathing, and significant fatigue—these factors combined with a notable weight loss might indicate a more serious health issue that requires further investigation.

Your ultrasound did not show remarkable findings, which is somewhat reassuring, but the increasing lymphocyte count in your blood tests suggests that your body is responding to some form of stress, which could be due to an underlying condition.

Next Steps

  1. Monitor Symptoms: Keep a close eye on your symptoms, especially any changes in the swelling, breathing difficulties, or if you experience fever or new symptoms like chills.

  2. Pain Management: Consider over-the-counter pain relievers like acetaminophen or ibuprofen, to ease discomfort as needed, unless contraindicated based on your previous treatments.

  3. Urgency Assessment: If your sympathies worsen or you experience shortness of breath that markedly impacts your daily activities, consider seeking emergency care sooner rather than waiting for your scheduled appointments. Severe fatigue that prohibits you from functioning normally is also a key symptom warranting urgent attention.

  4. Prepare for Your CT Scan: Make a list of all your symptoms and how they’ve changed, as well as your medical history, to discuss during your CT scan appointment and with your healthcare provider. This will help guide your diagnosis and potential treatment.

  5. Follow Up: After the CT, ensure you discuss the results and further steps with your doctor promptly. If your fatigue continues to worsen or you develop new symptoms, don’t hesitate to reach out before your next appointment.

Reassurance

It's good that you are monitoring these symptoms closely. While it's natural to worry about what potential conditions could be, staying organized and proactive in seeking care is the right approach. Your health concerns deserve attention and should be addressed thoroughly in your upcoming appointments. Remember to lean on your support system, including your wife, as you navigate this challenging health period. If any acute changes occur, please do not hesitate to seek immediate medical attention.

Related Questions

Concerns About Possible Incision Infection

Greetings everyone. I underwent a laparoscopic cholecystectomy through my navel just over a week ago, and I’m starting to feel anxious that my surgical site might be infected. Although my temperature has been consistently hovering around 99°F, indicating I do not have a fever, the area around the incision remains quite tender, and I've noticed some discharge. I’m doing my best to maintain cleanliness by gently applying soap to the incision during showers, as advised. After washing, I ensure it dries properly. I wonder if perhaps I’ve been overexerting myself without allowing sufficient time to rest. I returned to work five days after the surgery, where I am on my feet for extended shifts of over ten hours daily, and I also have three young children at home. While I’ve been cautious not to lift anything heavy, it’s been a challenge to balance everything. I’ve reached out to my surgeon's office for assistance, but they haven’t responded yet. I hope to connect with them tomorrow, but I would appreciate any insights or advice in the meantime.

COPDInternal MedicineRheumatology
Male25-34
3 minutes ago

Possible Causes for Cold-Induced Blue Discoloration of Hands

I am a 27-year-old female, standing at 5 feet 2 inches and weighing 120 pounds. My background is Middle Eastern, and I've grappled with this issue for several years now. The blue discoloration of my hands, fingers, and fingernails occurs particularly in cold conditions. My mother first pointed out the change in color. Sometimes, my hands also develop a reddish hue when irritated. As for my health, I do have a few concerns that might be connected. I'm currently managing anemia and a vitamin D deficiency, both of which are under treatment and monitoring. Recently, I underwent tests for autoimmune conditions, which revealed a positive result on the ANA screen with a higher titer of 1.40, exhibiting a nuclear and speckled pattern, although the cascade results were negative. I would appreciate any insights into what might be causing this condition or whether it warrants further concern. Regarding my medication regimen, I am taking lamotrigine (25 mg), fluoxetine (10 mg), Adderall (20 mg), vitamin D (25 mcg), ferrous sulfate (325 mg), and cetirizine (10 mg).

LupusFibromyalgiaCOPD
Male25-34
12 minutes ago

Concerns Over My Baby's Low Temperature

I am feeling quite perplexed regarding my 4-month-old daughter, who has been experiencing a cold along with a dry cough, all while the UK is enduring a heatwave. She was examined by her GP earlier this week, who noted that her tonsils were red but indicated she is battling a viral infection. Yesterday, she vomited a substantial amount of milk after a coughing episode, prompting us to contact the 111 health service. A pediatric nurse assured us that it wasn't a cause for alarm. Throughout the day, her temperature appeared normal, although her skin felt quite sticky; however, during the night, despite the room temperature soaring to 28 degrees Celsius, her underarm temperature dipped to 35.6 degrees. We shared this concern with the pediatric nurse, who advised us to add another layer of clothing to her and monitor her temperature, suggesting we reconnect if the situation did not improve. Since then, her temperature has stabilized around 35.8 degrees. Interestingly, when I cuddle her for feedings or when she wakes at night, her temperature does rise to 36 degrees or more. After reaching out to 111 again, I was informed that an ambulance would be dispatched—something we felt was excessive. The ambulance service later mentioned it would be better to await a GP visit. Although I could layer her up more, the heat in the room is quite uncomfortable. I find it difficult to relax and get any sleep due to my worries. Is there anyone who can offer advice until I can see a GP in the morning? What could be causing my baby's temperature to fall during her sleep?

LupusInternal MedicineEndocrinology
Male25-34
23 minutes ago

Unusual Neurological Symptoms Following Dental Appointment: Seeking Guidance After Months of Confusion

I am a 27-year-old male, standing at 5'11'' and weighing 200 lbs (I was 180 lbs when my symptoms first emerged). At the onset of these issues, I wasn’t under the influence of any drugs, be they prescribed or recreational. Presently, I’m not taking any medication, though I’ve undergone various treatments since the symptoms began, which I’ll elaborate on below. I had shared about this predicament six months ago, but I haven’t seen any effective treatment or received a clear diagnosis since. This update is more detailed, providing better context— my previous post can be found [here](https://old.reddit.com/r/AskDocs/comments/1ju79bg/incredibly_strange_neurological_symptoms_since/). To provide some context: I have dealt with OCD for my entire life. For a significant period, I managed it effectively and it didn’t interfere too much with my daily activities. However, after graduating from college in 2020, right as the pandemic began, I spiraled into depression. During that challenging time, my OCD escalated drastically, culminating in a brief but intense spell of paranoia where I felt as if I was being controlled by external forces—a startling experience unlike anything I had faced before. Eventually, I recovered from that episode, but my OCD had worsened considerably. I would find myself pacing and engaging in complex compulsions for hours each day for nearly two years, making it the most taxing period of my life. Unlike my previous experiences with OCD—more aligned with pure-O—this time my symptoms were primarily somatic. I felt unsettling crawling sensations and other intrusive feelings akin to someone looming over me. Even though I knew no one was there, the experience was discomforting. Cognitive fog enveloped me during this time, creating an almost continuous sensation akin to mental static. After about two years of heightened symptoms, an unexpected change occurred: my OCD vanished overnight. It was like a switch had flipped, and I found my body rejecting those compulsions entirely. For the next year, however, I struggled with depression and a profound lack of motivation. Simple tasks felt monumental, and I often sensed a disconnection from my prior life, with memories from before 2020 appearing dreamlike. Starting in early 2023, I resolved to regain a sense of normalcy. I made a concerted effort to reconnect with friends and engage in ordinary activities again. I had reached a point where even listening to music felt overwhelming, triggering panic. By last year, I had made substantial progress—I moved to a new city to be closer to friends, participated in more activities, and my memories felt increasingly vivid and real. However, around mid-2024, I started experiencing eye strain when I attempted to visualize memories from before 2020. I would feel pain in my eyes, accompanied by pressure, which I rationalized as fatigue from my efforts to recall those memories. In November 2024, during a dental appointment for fillings, I experienced a panic attack, which exacerbated my eye strain as I relived my life experiences. Following the administration of local anesthetic, my anxiety escalated, causing pain and leading to a surreal, dream-like state. After one specific shot, warmth coursed through my body, akin to intoxication, as if I was falling into a dream, with my grip on reality loosening. I initially attributed this experience to medication side effects but grew concerned when symptoms persisted for over three days. Since then, I’ve consulted numerous neurologists and psychologists, yet a definitive diagnosis remains elusive. One doctor speculated about temporal lobe epilepsy, leading to a month on Lamictal and four months on Trileptal, neither of which improved my condition. An EEG conducted during a particular spike in symptoms returned normal, rendering the epilepsy hypothesis unlikely. While my grasp on reality remains largely intact, my mental state feels profoundly distorted and unsettling. Below are some of the symptoms I experience: - My OCD seems completely absent, devoid of any familiar obsessions or compulsions. However, the somatic sensations I once felt have returned, intensified; I frequently experience a feeling of being invaded by entities that I rationally know aren’t present, yet it’s highly distressing. Unlike before, when I could push away those sensations, they now feel invasive and uncontrollable. - Although my factual memory appears intact, the nature of my thoughts feels jumbled. It is as if a mental barrier has shattered, allowing an unfiltered flood of thoughts to intrude upon my consciousness. Alarmingly, it feels like my mind is being rewritten against my consent, with a metaphorical crank altering my thoughts unexpectedly, leaving me panicked and helpless. For instance, a pleasant memory might suddenly morph into a frightening one, and despite knowing it’s an illogical change, I find myself unable to resist. - I experience an intense sense of being “inside out,” as if trapped in a half-awake state where external sensory input streams directly into my mind. This amalgamation of sensory experiences never fades, only accumulates into a chaotic mass of sensations, including physical discomfort from sight or smell—while the latter feels quite real, akin to smelling something directly placed near my face. - Strange physical manifestations correlate with my mental disarray. The mental agitation can trigger intense gagging and vomiting, sometimes severe enough to be involuntary, alongside bodily pain that can feel constrictive. - An incessant need to move accompanies my discomfort, making it difficult to remain still and amplifying that ever-present sense of mental static. - I’ve been plagued by ongoing eye strain, akin to a persistent hangover, 24/7. Dark circles under my eyes are evident, becoming a noticeable feature of my appearance. - Additionally, I face various unusual facial pains, particularly in the central region, which feels strange and foreign. Tests for trigeminal and facial nerve issues have returned normal results, though further investigation might be necessary. - My sleep feels inadequate; the lines between sleeping and waking have blurred. Instead of restful slumber, it often feels like the chaotic sensations take over, leading to vivid dreams and no true recovery. I am filled with anxiety over this situation and still remain undiagnosed. Does anyone reading this find any of my experiences familiar?

Multiple SclerosisLupusThyroid Disorders
Male25-34
32 minutes ago

Understanding Myelomalacia: A Personal Account

In my experience with multiple sclerosis, I discovered that my neurologist had not reviewed any of my MRI reports since 2015. It wasn't until I obtained the records in 2022 that I learned about the presence of myelomalacia, a herniated disc, and moderate spinal stenosis in my condition. Alarmingly, my spinal cord is now showing signs of flattening. To make matters worse, I found out that my case file has been marked, preventing other doctors from referring me to a spine surgeon or conducting an EMG test. It seems there is an ongoing attempt to conceal my neurologist's oversight. As a proactive step, I have transferred my medical records to the MS Clinic at Burnaby Hospital in hopes of receiving the necessary care. However, if I do not see progress, I am considering reaching out to the media and potentially seeking surgical treatment abroad in Mexico.

Multiple SclerosisLupusEndocrinology
Male25-34
33 minutes ago