Managing Recurrences of Mycoplasma Genitalium
Hello, I’m a 27-year-old male who has sex with men (MSM), standing at 6 feet tall and weighing 70 kilograms, of Middle Eastern descent, and I’m currently on PrEP. I’m fortunate to have no health issues. Largely engaging in receptive sexual activities, I often do not consistently use condoms. I recently discovered that I have contracted Mycoplasma genitalium for the third time. My infectious disease specialist has prescribed a treatment regimen consisting of two weeks of doxycycline followed by three weeks of moxifloxacin. I have noticed an improvement in my symptoms. I’m curious to know, can this bacteria completely clear from my system only to reappear later by itself? Or is it more plausible that I’m experiencing a reinfection?
Answers (1)

7/1/2025, 5:30:57 PM
OpenHealth AI
It sounds like you're facing some challenges with recurrent Mycoplasma genitalium infections. This bacterium can indeed lead to repeated infections, and addressing both treatment and prevention is important for your health.
Key Points:
- Mycoplasma genitalium can clear from your system after treatment, but reinfections are common.
- Reinfection typically occurs due to exposure during sexual activities, especially with inconsistent condom use.
Explanation:
Mycoplasma genitalium is a sexually transmitted infection (STI) that can be effectively treated with antibiotics. After your course of doxycycline and moxifloxacin, it's possible for the bacteria to be fully eliminated, but if you continue to engage in sexual activities without consistent condom use, you may be at risk for reinfection from an untreated partner or through new exposure.
Next Steps:
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Complete Your Treatment: Ensure you finish the entire prescribed course of both doxycycline and moxifloxacin as directed by your healthcare provider to effectively clear the infection.
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Monitor Symptoms: Keep track of any symptoms that may reappear after completing your treatment and report these to your specialist.
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Discuss Sexual Health with Partners: Open a dialogue with any sexual partners about STIs and consider having them tested, especially if they’re experiencing any symptoms. This can help prevent reinfection.
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Practice Safer Sex: Until you and your partners are tested and treated as necessary, consider using condoms consistently to reduce the risk of transmission and reinfection.
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Follow-Up Testing: Discuss with your healthcare provider the timeline for follow-up testing to confirm that the infection has been effectively cleared and to check for any potential reinfections.
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Regular Check-Ups: Since you are on PrEP, regular health check-ups can help you stay on top of your sexual health and any potential infections.
Focusing on these steps will help you manage your situation effectively and work towards preventing future occurrences. If any further questions or concerns arise, feel free to reach out for more information.
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