Persistent Lip Infections: A Personal Account
Hello, I'm a 17-year-old male, standing 5 feet 9 inches tall and weighing 140 pounds. I lead a healthy lifestyle, exercising regularly at the gym. Here's my journey: Two years ago, during my sophomore year, I encountered lip infections, specifically impetigo. My doctor prescribed mupirocin ointment at 2%, which successfully cleared the infection. A year later, I had a recurrence, though milder this time. I applied the same ointment, and again the infection resolved without complications. This April marked the third occurrence. By the time I visited my doctor, the infection appeared to be healing and was relatively mild. I was advised to continue using mupirocin, and the doctor also prescribed Valacyclovir 500 mg, suspecting it might be a cold sore since I do experience those occasionally. It's essential to highlight that all these infections manifested on my upper lip, resulting in crusty, yellow lesions that were painful. On this latest episode, I allowed the infection to heal naturally, which unfortunately left a scar on my upper lip. Sadly, just a few days later, it reappeared in the same spot, prompting me to resume treatment with mupirocin. While it began to improve, towards the end of my treatment—around the 4th or 5th day—I woke up to find my entire lower lip covered in red sores and blisters. They burst and developed a thick yellow crust, making it the most severe outbreak I’ve experienced, rivaling my initial impetigo incident as a sophomore. I sought care at an urgent clinic, where I was prescribed cephalexin (Keflex) for the oral infection, which fortunately aided in its resolution. Additionally, I was diagnosed with oral thrush and given a prescription for Nystatin. One week later, I noticed another small yellow-crusted lesion on my lower lip, prompting me to consult a specialist. In the meantime, I turned to applying plenty of Vaseline, hoping to moisturize and protect the area. For about two weeks, I was free from a major infection but experienced intermittent pain and crusting. During this time, a cold sore appeared on my upper lip, but Valacyclovir managed to control it effectively. During my appointment with the specialist on June 3rd, they suspected I might be harboring bacteria, pointing out that the corners of my mouth could be entry points for infection. Previously, during my second infection, I had significant pain at the corners, making it difficult to eat. The third bout also included discomfort in those areas, although the most recent outbreak on my lower lip didn’t. The specialist prescribed mupirocin again, along with hydrocortisone 2.5% as a precaution for any potential flare-ups at the corners of my mouth. For about two weeks, my condition seemed to stabilize, with occasional twinges of pain, but then I experienced yet another infection on my lower lip. A swab test indicated normal skin flora, yet the doctor cautioned that it could have been a false negative due to the absence of pus or liquid for testing. I treated the infection again with mupirocin, leading to healing, although a minor spot persisted. Following my specialist's advice, I extended the usage to nine days. However, on the ninth day, I noticed the familiar red, blister-like bumps returning to the same areas on my lower lip. This morning, I woke to find crusting, yellowing, and discomfort reemerging, as if I were caught in a recurring cycle. In addition, I’ve been applying the ointment inside my nostrils, suspecting there might be colonization there. Currently, I feel quite discouraged and overwhelmed. The idea of possibly having MRSA and being permanently colonized is frightening. While I recognize the swab may not have been definitive, the anxiety of this becoming a persistent problem weighs heavily on me. Sleep has evaded me, as I'm often kept awake due to pain or from worrying late into the night. It may seem trivial, but this situation deeply impacts me emotionally; I fear never being able to kiss anyone again without anxiety. I am simply worn out. I have a follow-up appointment in two days and intend to continue my consultation with the specialist. However, if this does turn out to be MRSA, I wonder what steps I can take to prevent future outbreaks. Is full decolonization achievable? Or will this be a long-term challenge I need to face?
Answers (1)

7/1/2025, 9:50:48 PM
OpenHealth AI
I'm sorry to hear about the persistent struggles with your lip infections. It's understandable to feel overwhelmed and anxious about your situation, especially since it's affecting your daily life and emotional well-being.
Main Points:
- You have experienced recurrent lip infections, potentially including impetigo and cold sores, leading to a cycle of outbreaks.
- Your recent experiences have understandably caused significant anxiety about your health, particularly concerns regarding MRSA.
- You are on the right path with expert consultations and treatments.
Explanation:
Lip infections, especially recurrent ones, can be incredibly frustrating. It's common for bacteria to establish a recurring presence, especially in moist areas like the corners of your mouth. Cold sores (herpes simplex virus) can also complicate matters, leading to overlapping symptoms that might mimic bacterial infections. Your care team’s considerations of bacterial colonization are crucial, and it's good that you are vigilant about your care.
Next Steps:
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Continue Current Treatments: Continue using mupirocin and hydrocortisone as prescribed, ensuring you follow your specialist’s advice closely. If you notice any new signs of infection, report them during your follow-up appointment.
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Moisturize & Protect the Area: While using Vaseline or a similar protective ointment can help, ensure it doesn't combine with other products in a way that could trap bacteria.
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Identify Triggers: Keep track of potential triggers for your outbreaks, such as stress, diet, weather changes, or activities. Understanding these can help you discuss prevention strategies with your specialist.
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Personal Hygiene: Maintain strict hygiene around your lips and avoid touching your face or lip area with unwashed hands. Wash your hands frequently, especially after touching contaminated surfaces. Consider using a separate towel for your face.
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Discuss Decolonization: In your upcoming appointment, openly discuss the potential for MRSA colonization with your specialist. If it is confirmed, they may recommend decolonization strategies, which often include a combination of topical and oral antibiotics, as well as antiseptic body washes.
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Mental Health Support: Since this situation has understandably caused you emotional distress, consider speaking to a mental health professional. Managing anxiety and stress can sometimes help alleviate physical symptoms and support overall well-being.
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Follow-Up Tests: If necessary, ask about further testing to clarify the exact nature of your infections. Your healthcare team may suggest testing for viral or bacterial allergies, which could guide you toward effective treatments.
Conclusion:
It's completely normal to feel discouraged, but you're taking the right steps by continuing to seek medical help. With time and the right strategies, managing these infections is possible, and you are not alone in this experience. It's important to prioritize your health holistically, reflecting on both physical symptoms and mental health aspects. Stay proactive with your healthcare discussions, and let me know if you need more specific information or support.
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