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Is it Safe to Experiment with Ayahuasca While Taking Vyvanse?

4/2/2025, 9:20:16 PMMale25-34

I’m currently using Vyvanse to manage my ADHD, but I’m curious about exploring ayahuasca. My primary concern is the potential interaction between an MAOI and Vyvanse. Would it be advisable for me to discontinue Vyvanse for a few days, experience ayahuasca, and then resume taking Vyvanse a day or two later? I'm 30 years old, male, 5 feet 6 inches tall, and weigh between 9 and 10 stone. I identify as white. I am located in the UK and have ADHD as my existing medical condition. At the moment, my only medication is lisdexamfetamine.

ADHDPediatricsChild Psychology

Answers (1)

Cony

4/2/2025, 9:20:30 PM

OpenHealth AI

Experimenting with ayahuasca while taking Vyvanse (lisdexamfetamine) is not considered safe. The combination raises significant concerns due to potential interactions and health risks, particularly because of the effects of monoamine oxidase inhibitors (MAOIs) commonly found in ayahuasca.

Explanation

Vyvanse is a stimulant medication primarily used to manage ADHD by increasing the levels of certain chemicals in the brain that help with focus and impulse control. Ayahuasca, on the other hand, is a brew made from various plants, containing psychoactive compounds and often includes an MAOI.

When taken together, the risk of serious side effects, such as hypertensive crises (extremely high blood pressure) or other dangerous cardiovascular reactions, increases significantly. These interactions can be unpredictable and potentially life-threatening.

Next Steps

  1. Avoid Combining Substances: Do not experiment with ayahuasca while you are on Vyvanse or other stimulant medications. The risk far outweighs any potential benefits.

  2. Consider Alternative Approaches: If you are seeking new therapeutic experiences, consider discussing other evidence-based options with a healthcare professional that fits your mental health needs.

  3. Monitor Your Mental Health: If you're feeling dissatisfied with your current treatment or curious about alternatives, keep a journal of your experiences and symptoms. This can be helpful when discussing your treatment plan with a healthcare provider.

Remember, your safety is paramount, and it’s crucial to make informed choices regarding your mental health and treatment. If you have further questions or concerns, feel free to ask for more information.

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