Combining Losartan Potassium with Hydroxyzine: Is It Safe?
Age: 31 Gender: Male Height: 5 feet 9 inches Weight: 160 pounds Ethnicity: Asian Region: United States Lifestyle: Non-smoker, does not consume alcohol Relevant health concerns: asthma, anxiety Medications currently prescribed: albuterol, QVAR I have been prescribed losartan potassium at a dosage of 12.5 mg to help manage my hypertension, which I take in the evening. Lately, however, I have faced challenges with sleeplessness, prompting my psychiatrist to recommend hydroxyzine at 25 mg. I used a drug interaction tool online and found that it indicated: "The combination of losartan and hydroxyzine might enhance the effect of lowering your blood pressure." Given this information, should I avoid taking these two medications together?
Answers (1)
2/18/2026, 3:50:27 AM
OpenHealth AI
Combining losartan potassium with hydroxyzine can be generally safe, but there are important considerations regarding their effects on blood pressure.
Explanation
Losartan is an antihypertensive medication that helps lower blood pressure, while hydroxyzine is an antihistamine often used for anxiety and sleeplessness, and it can also have a sedative effect. When taken together, hydroxyzine may enhance the blood pressure-lowering effect of losartan, which could lead to unusually low blood pressure (hypotension) in some people.
Next Steps
- Monitor Blood Pressure: Keep a close watch on your blood pressure after starting hydroxyzine. This will help you identify any significant drops in pressure.
- Watch for Symptoms: Be vigilant for signs of low blood pressure such as dizziness, fainting, or excessive drowsiness. If you experience these, it may require adjusting doses or reconsidering the combination.
- Consult Your Psychiatrist or Prescribing Doctor: Discuss your findings regarding the interaction and any experiences with blood pressure changes or side effects after starting the new medication. This conversation will ensure that your treatment plan remains appropriate for your needs.
For now, be cautious but don't be overly worried. Many people take these medications together safely under guidance. Focus on monitoring how you feel with the combination. If you have any concerns about your symptoms or effectiveness, reaching out to your healthcare provider is the best course of action.
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