Experiencing Full Body Hives After Starting Tretinoin
Age 26, based in the USA – Recently, I began using Tretinoin at the lowest concentration to combat acne, alongside a benzoyl peroxide cream in the morning. Initially, I applied both products for two consecutive days despite knowing better; my eagerness for visible results got the best of me. By Friday, I noticed hives developing on my neck, prompting me to discontinue Tretinoin. I switched to a mild cleanser and moisturizer instead. However, by Saturday morning, I woke up with hives all over my body, and as of Sunday evening, they persist. Is this a common reaction? Would it be safe to resume using Tretinoin if I spaced out the applications (perhaps using it every three days or so)?
Answers (1)
2/9/2026, 2:20:31 AM
OpenHealth AI
It sounds like you're experiencing a significant reaction after starting Tretinoin, and I can understand how concerning this must be. The development of full body hives is not a typical response to Tretinoin but could be a sign of an allergic reaction or sensitivity, especially considering you were using it alongside benzoyl peroxide.
Explanation:
Tretinoin can cause skin irritation, but hives (urticaria) usually indicate an allergic response. Since you saw hives after beginning treatment and after combining both products, it’s possible that one or both of these medications contributed to the reaction. Allergies can vary widely in severity, and the persistence of hives over more than a couple of days warrants careful monitoring.
Next Steps:
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Discontinue Use of Tretinoin and Benzoyl Peroxide: Since you’ve already stopped using Tretinoin, it’s wise to avoid both products for now to see if your symptoms improve.
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Manage Hives:
- Over-the-counter Antihistamines: Consider taking antihistamines like diphenhydramine (Benadryl) or cetirizine (Zyrtec) to help relieve itching and reduce hives. Follow the dosing instructions on the package.
- Cool Compresses: Apply a cool, damp cloth to the affected areas to soothe your skin and minimize discomfort.
- Hydration: Drink plenty of water to help your skin stay hydrated.
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Monitor Symptoms: Keep a close watch on your hives. If they worsen, or if you experience other symptoms like difficulty breathing, swelling around your eyes, or lips, seek emergency medical attention.
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Consider Resuming Tretinoin Later (if symptoms improve): Once the hives have fully resolved, and if you wish to try Tretinoin again, consult a dermatologist for personalized advice. A patch test or starting with a lower concentration and increasing the intervals between applications could be a strategy, but this should be done under supervision.
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Document Symptoms: Keep a diary of any new products you try and any reactions you have, which can help in identifying specific triggers with your doctor in the future.
Stay patient with your skin care journey, and remember that it’s important to prioritize your health and safety over speed in seeing results. If you’d like more assistance or have further concerns, please reach out.
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