Seeking Guidance on Hormonal Treatment as a Trans Man
I am a 21-year-old transgender man (FTM). About a year ago, I began receiving testosterone injections using a product called Testoviron, administered at a dosage of 125mg biweekly. During my most recent appointment with my endocrinologist, we chose to switch to an alternative injection called Nebido, which is a 250mg dose given every 12 weeks. My concern is whether extending the interval between these injections will slow my overall progress. Additionally, I've heard it may be necessary to have a second shot six weeks after the initial one to enhance the effectiveness of the treatment. After reading some online, I noticed that this advice is common; however, I feel uncertain as my endocrinologist appears to have limited experience working with transgender patients. This has left me anxious about the potential effects of the hormonal therapy. I would greatly appreciate any insights or advice on this matter.
Answers (1)
2/7/2026, 3:10:31 AM
OpenHealth AI
Your concerns about switching to Nebido and the potential effects on your hormonal treatment are valid, and it’s great that you’re actively seeking information. Let’s address your specific questions regarding the change in testosterone therapy and the dosing schedule.
Key Points:
- Impact of Extended Dosing Intervals: Switching to Nebido, which is a longer-acting form of testosterone, typically can be effective for sustained hormone levels over time, but it may react differently in individuals.
- Additional Injections for Effectiveness: It is true that some individuals may benefit from an additional injection 6 weeks after the initial dose to help stabilize hormone levels in the beginning.
Explanation: When you switch to a longer-acting testosterone such as Nebido, the goal is to maintain stable testosterone levels with fewer injections. While your prior method required more frequent doses, the extended interval doesn’t inherently mean you’ll progress more slowly, but it can take time to find the right balance.
If the first injection isn’t enough to provide sufficient hormone support, the recommendation for a second shot 6 weeks later can help achieve more stable levels sooner. These initial adjustments are quite common as your body adapts.
Next Steps:
- Monitor Your Symptoms: Keep track of how you feel after switching to Nebido—pay attention to any changes in mood, energy, or physical changes.
- Discuss Injection Timings: If you feel uncertain about the timing of injections, discuss potential gradual adjustments with your endocrinologist or another healthcare provider experienced in transgender care to optimize your treatment plan.
- Consider Additional Support: If you have concerns about your endocrinologist’s experience with transgender patients, you may want to seek a second opinion from a provider who specializes in transgender healthcare to ensure the best advice and tailored care.
- Stay Educated: Continue to read reputable resources about testosterone therapy in transgender men, as understanding the process can empower you.
Feel free to reach out if you have more questions or need further support. Your well-being is important, and it's essential to advocate for your health.
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