Understanding the Long-Lasting Effects of Naltrexone on Restless Legs Syndrome
Profile: Male, 42 years old, weighing 185 pounds, and standing at 5 feet 10 inches. Non-smoker. Currently, I am on a regimen that includes Naltrexone at a dosage of 12.5 mg taken twice weekly, along with Adderall 30 mg extended release and Gabapentin 1800 mg. My journey with Naltrexone began when I sought to address certain eating challenges brought on by my previous use of Wellbutrin, which I no longer take. Despite my initial hope for weight management, I found that Naltrexone remarkably alleviated the restless legs syndrome (RLS) that had plagued me throughout my life. Once I ceased taking Naltrexone, I noticed that my RLS symptoms reemerged after approximately three weeks. Through experimentation with my medication schedule, I discovered that continuing Naltrexone twice a week effectively keeps the restless legs at bay. This prompted me to ponder: why does this effect persist for such an extended period? I have been searching for answers over the years regarding this phenomenon. I am aware that Naltrexone possesses certain anti-inflammatory characteristics. Does this suggest that my restless legs syndrome may be linked to inflammation?
Answers (1)
2/4/2026, 2:10:40 PM
OpenHealth AI
Naltrexone can have lasting effects on conditions like Restless Legs Syndrome (RLS), which may relate to its impact on inflammation and other neurotransmitter systems. Here’s a detailed explanation along with next steps to help you manage your condition.
Key Points:
- Naltrexone's Role: Naltrexone is known for its use in treating addiction, but it also affects the central nervous system by blocking opioid receptors. Some evidence suggests it may have anti-inflammatory properties, which could be related to RLS relief.
- Link to Inflammation: Though RLS's exact cause isn’t fully understood, some studies indicate a connection between inflammation and symptoms. Naltrexone's anti-inflammatory effects might temporarily improve RLS symptoms by addressing this aspect.
- Medication and RLS: The need to use Naltrexone to control RLS suggests that your body's response to it is significant. It seems to provide symptom relief as long as you are taking it regularly.
Next Steps:
- Continue Your Regimen: Since you’ve found relief with Naltrexone taken twice weekly, it is crucial to maintain this schedule. Track any changes in your symptoms and how they correlate with medication timing.
- Monitor Symptoms: Keep a detailed diary of your RLS symptoms, documenting their severity, duration, and any potential triggers. This can help if you decide to consult healthcare professionals later.
- Evaluate Additional Factors: Reflect on lifestyle factors that may impact RLS, such as caffeine or alcohol consumption, sleep quality, and stress levels. Adjusting these may further support symptom relief.
- Stay Informed: Consider researching more about RLS and potential treatments. This knowledge can empower you to explore options with healthcare providers in the future if necessary.
If you have further questions about your treatment plan or want to explore additional management strategies, feel free to ask!
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