Does Long-Distance Running Lead to Increased Red Blood Cell Size (MCV)?
Hello, I recently underwent a blood test and my results indicated an MCV of 105.7. Fortunately, my levels of vitamin B12 and folate are normal, though my ferritin is slightly elevated. I don’t consume alcohol and I don’t smoke. My measurements are 165 cm in height and weigh 52 kg. Additionally, I’m not currently taking any medication. As a regular long-distance runner, I engage in significant elevation, although my recent activities have been quite minimal. My physician would like to schedule a follow-up appointment for further investigation. I’m curious if my practice of long-distance running could be the sole reason for the increase in my red blood cell size. Thank you!
Answers (1)
2/3/2026, 9:30:34 AM
OpenHealth AI
Your elevated mean corpuscular volume (MCV) of 105.7 could indeed be influenced by various factors, including your long-distance running regimen. While physical exercise, particularly endurance activities like long-distance running, can impact several aspects of your blood and physiology, it’s important to explore the potential causes for this specific change.
Explanation: MCV measures the average size of your red blood cells. Elevated MCV can occur for several reasons:
- Nutritional Factors: While you mentioned that your B12 and folate levels are normal, deficiencies in these vitamins are commonly associated with increased MCV. However, normal levels indicate that nutrition is likely not the main cause.
- Hydration Status: Runners often experience fluctuations in hydration, which can affect blood chemistry and cell dynamics.
- Bone Marrow Activity: Intense exercise can influence bone marrow function and the production of red blood cells, potentially leading to changes in MCV.
Given your active lifestyle and relatively high MCV, it’s reasonable to consider that your training might be a contributing factor, but other medical evaluations are warranted to rule out any underlying conditions.
Next Steps:
- Hydration: Ensure you are properly hydrating, especially before and during runs, as dehydration can impact blood parameters.
- Monitor Symptoms: Keep track of any additional symptoms you may experience such as fatigue, dizziness, or changes in performance.
- Follow-Up Appointments: Attend the follow-up appointment with your physician for further testing and evaluation. They may want to conduct more blood tests or investigate other potential causes for the elevated MCV.
- Diet Review: Consider evaluating your diet to ensure you’re obtaining a balance of necessary nutrients, not just B12 and folate, but also iron and other vitamins.
The combination of your active lifestyle and laboratory findings warrants careful monitoring but does not necessarily indicate a severe problem. Addressing these areas will give you valuable insights into your health and help rule out concerns. Please keep me updated on your situation or if you have further questions!
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