OpenHealth Q&A

Get answered by medical professionals

Understanding the Implications of Lesion Size in Cancer Diagnosis

12/17/2025, 2:50:20 PMMale25-34

Recently, my father, who is 55 years old, underwent a colonoscopy, during which a notably large "polyploid lesion" was discovered. It was characterized by its substantial width and height, raising significant concerns. While the doctor acknowledged its large size, no specific measurements were provided; however, they did mention that it approaches a threshold that could indicate a blockage. Currently, we are waiting for the results of a biopsy and an MRI. Unfortunately, due to the Christmas holidays, we are not expecting any information until at least the week following Christmas, or potentially the week after that regarding whether it is cancerous and its potential stage. For the time being, the medical team is operating under the assumption that it is indeed cancer. They have expedited the process as much as possible, but we’re left with a sense of uncertainty during this anxious waiting period. I am feeling quite fearful and overwhelmed by the situation, and the delay is particularly tough. I’m wondering if the large size of the lesion can provide any insights into its stage, should cancer be confirmed, or give any clues about its nature.

Multiple SclerosisCrohn's DiseaseThyroid Disorders

Answers (1)

Cony

12/17/2025, 2:50:41 PM

OpenHealth AI

I'm deeply sorry to hear about your father's situation. It's completely understandable to feel anxious and overwhelmed when awaiting critical medical information, especially concerning a loved one's health. Let's address your concerns regarding the implications of the large lesion and what steps you can take while you wait for results.

Main Points

  • The size of a lesion can indicate potential severity but does not solely determine its nature or stage.
  • Waiting for biopsy and MRI results can be incredibly stressful; focusing on supportive actions can help manage anxiety.

Explanation

A "polyploid lesion" often indicates a growth that could be benign or malignant, and while its size is concerning, it isn't directly indicative of cancer stage. Larger lesions could potentially lead to complications like blockage but won't determine if it's cancerous or the extent if it is. The final diagnosis relies heavily on the biopsy results, which will identify whether the lesion is cancerous and, if so, what type. The MRI can provide additional information about its surrounding tissues and potential spread.

Specific Next Steps

  1. Stay Informed: While waiting, educate yourself about polyps and polyploid lesions. Knowing more can ease some anxiety by understanding the typical progression and characteristics.

  2. Supportive Care: Encourage your father to maintain a healthy diet, stay hydrated, and manage stress as best as possible. Gentle activities like walks or mindfulness exercises may also be beneficial.

  3. Open Communication: Keep in touch with your healthcare team. If you have specific anxieties or if there are concerning symptoms like pain or changes in bowel habits, don’t hesitate to communicate those needs.

  4. Emotional Support: Share your feelings with family members or friends, and consider support groups for caregivers. Talking to others who have been through similar experiences can help alleviate some of the emotional burden.

  5. Plan for Next Steps: Once the results come in, discuss the findings with the doctor to understand the implications fully and make informed decisions about potential treatments or further actions.

Conclusion

It's a challenging time filled with uncertainty, and your feelings are valid. Focus on these steps to help navigate the waiting period while ensuring your father stays supported. If you need more information or if additional questions arise, feel free to reach out. Wishing you both strength during this time.

Related Questions

Experiencing Widespread Muscle Weakness

I’m a 36-year-old male and have recently been facing a troubling situation where the muscles throughout my body seem to be losing function—including my eyelids. The trouble began in May 2021 when I lifted a heavy garbage can with my right arm in a shrugging action. Following that, I felt a combination of pain and weakness concentrated in my right shoulder blade, as well as my shoulder and collarbone. Soon after, I noticed my shoulder began to pop and click. Afterward, I consulted with an orthopedic specialist who conducted x-rays on both of my shoulders. He informed me that everything appeared normal and dismissed the popping sounds as inconsequential. I also mentioned experiencing neck pain, but he indicated that addressing neck issues wasn’t his area of expertise. He diagnosed me with bilateral shoulder and neck discomfort and recommended physical therapy. The day after my appointment, I attempted to adjust my position in my desk chair by leaning on the left armrest, putting my forearm under the weight of my body. Suddenly, my shoulder jolted, and I felt a sharp weakness in my arm, accompanied by popping and clicking noises, similar to what happened with my right arm. I reached out to the orthopedic office to inform them about this incident, but the physician assistant who responded said the doctor would not see me again simply due to how I was sitting, and suggested I attend physical therapy first. She mentioned that if I continued to experience weakness, a neurologist might be necessary. Feeling concerned, I returned to my primary care physician for a follow-up appointment and recounted my experience. He didn’t appear worried, and my blood tests returned normal results. During the summer of 2021, I began physical therapy where the therapist diagnosed me with strains in my trapezius and rhomboid muscles. The subsequent therapy sessions consisted of painful exercises and stretches, yet I observed little to no improvement in terms of strength or stability. Activities like using the arm bike and weight machine were excruciating, and I frequently inquired whether my symptoms could be attributed to a tear or nerve damage, but the therapist insisted that was not the case and dismissed my concerns. After my tenth session, I decided it was best not to return. In April 2022, I visited a neurologist. I struggled to lift myself onto the examination table and needed assistance from a step stool. He didn't suspect any neurological issues when I asked him about an EMG or other assessments, he declined to proceed with those tests. Disheartened by these experiences, I chose not to pursue further medical consultations. Fast forward to April 9, 2025, I misstepped while descending some stairs, causing my right heel to catch, and I landed hard with my toes pointed. I had no visible signs of injury such as swelling or bruising, but soon after, I began to experience persistent pain and weakness, especially in my toes and the arch of my foot. By April 13, I instinctively elevated the toes on my left foot, and to my dismay, the same pain and weakness emerged, again without any visible signs like bruising. Since then, both feet have lacked strength, and my big toes feel unusually floppy. In July 2025, I had a troubling experience after having my hair washed at a salon. I held my neck in an awkward position for the duration, which resulted in a burning sensation. Regrettably, I didn’t express my discomfort, fearing a scene. Following this, I noticed significant weakness in the muscles at the front of my neck, under my chin, which gave the appearance of a receding chin. Additionally, my facial muscles, particularly in my cheeks, felt weak and could easily be pressed in with minimal resistance. In January 2026, I bought a new game controller for my laptop, having not played video games for a long time. Initially, it was manageable, but soon after, my hands and forearms began to feel uncomfortable and painful. This discomfort escalated significantly to where I had to discontinue use completely; my hands felt drained of energy and experienced achiness, tingling, and numbness. Then, on February 3, 2026, while seated and using my laptop, I noticed a peculiar sensation when moving my eyes. My eyelid muscles felt weak, and one of my eyelids began twitching. I found it increasingly difficult to open my eyes as widely as I used to. I plan to see a primary care physician once more, but I’m uncertain how to communicate all of this effectively to receive proper care. My circumstances have reached a point where my parents must assist me with everyday tasks, including driving, opening doors, and even lifting light objects. My ability to raise my arms above my head has become severely limited as well.

Multiple SclerosisFibromyalgiaCrohn's Disease
Male25-34
14 minutes ago

Liver Mass Assessment

Patient Profile: - Age: 61 years - Height: 5'9" - Weight: 240 lbs - Gender: Female - Lifestyle: Non-drinker, non-smoker, no illicit drugs Current Medications: - Atenolol 10mg (morning and evening) - Rosuvastatin 40mg (evening) - Duloxetine 60mg (evening) - Spironolactone 25mg (recently added) - Jardiance 10mg (recently added) Medical History: The patient has a notable history of multiple pheochromocytomas and paragangliomas, having undergone surgery on eight occasions. According to scans performed three years ago, two subcentimeter retroperitoneal masses were identified, suggestive of potential paraganglioma. Additionally, she suffers from secondary polycythemia and possesses the PHD1 gene mutation. Previously, she received treatment at a prominent research institution in the United States. However, her endocrinologist has since retired and returned to their home country. Current Condition: At present, she is mostly asymptomatic. However, in January 2026, she experienced a concerning event requiring an ambulance transport to a local emergency room, where her oxygen levels registered at 88-89%. This incident was unsettling, given her extensive medical history. The emergency physician initially diagnosed her with congestive heart failure (CHF), but upon discharge, her family medicine doctor suggested pneumonia. During her hospital stay, a cardiologist—who has never managed a pheochromocytoma patient—recommended a chemical stress test. A CT scan performed on her chest revealed a 3.2 x 2.5 cm mass located in the left lobe of her liver. Her blood tests typically show elevated levels related to pheochromocytomas; however, the laboratory does not conduct resting catecholamine testing, which leads to unreliable results, despite them being consistent over time. Furthermore, she has received care at major hospitals in Minnesota and both leading hospitals in Cleveland, Ohio. Unfortunately, when she required her last surgery, the tumor board declined her case, citing an unfavorable risk-benefit ratio. This leaves her without a specialist in pheochromocytomas. Request for Guidance: The patient is seeking advice or recommendations for her current health situation and management of her conditions.

Crohn's DiseaseThyroid DisordersEndocrinology
Male25-34
35 minutes ago

Concerns About My Daughter's Morning Health Issues

My 17-year-old daughter experiences troubling symptoms each morning, particularly on days when she needs to rise early for school or work. She often wakes up feeling dizzy and nauseated, accompanied by a rapid heartbeat exceeding 100 beats per minute. This situation prevents her from being able to eat and may persist for several hours, or in some cases, throughout the entire day. Standing at 5 feet 8 inches tall (172 cm) and weighing 121 pounds (55 kg), her physical health otherwise seems fine. I have a personal history of inappropriate sinus tachycardia (IST), which is why I take beta-blockers for management. A few years ago, she consulted a cardiologist regarding her frequent episodes of near-fainting, who recommended increasing her water intake and adding more salt to her meals. Given the persistent nature of her symptoms, I am contemplating whether a follow-up appointment with the cardiologist is warranted, especially since all previous tests, including ECG and ultrasound, came back normal. This situation significantly affects her daily life, restricting her ability to engage fully in school and work. Any suggestions would be greatly appreciated!

Crohn's DiseaseThyroid DisordersCOPD
Male25-34
1 hour ago

Concerns Regarding Neurological Health

Hello! I received an epilepsy diagnosis back in 2008, and throughout this time, various MRI and CT imaging studies have indicated issues related to cerebral function and encephalopathy. Despite consulting multiple neurologists over the years, I’ve found that none of them appear worried about the encephalopathy aspect. Shouldn’t this be something to take more seriously? My cognitive abilities, including memory and vision, have noticeably deteriorated as time has passed. I’m feeling lost since my previous neurologists have not acknowledged my concerns adequately. If anyone could offer guidance or suggest resources, I would greatly appreciate it. In addition to epilepsy, my other medical conditions include Narcolepsy, Lynch Syndrome, Migraines, a mutation associated with HLA-B27, and Hashimoto's disease, along with others that escape me for the moment. Currently, I’m on a medication regimen that includes Lamictal, Xcopri, Hydroxyzine, Solifenacin, Zoloft, Wellbutrin, Sunosi, Aimovig, and Famotidine.

Multiple SclerosisLupusThyroid Disorders
Male25-34
1 hour ago

Navigating the Complexity of Symptoms: Is It PCOS or Something Else?

While I’m not an expert in self-diagnosis, I find myself puzzled by an array of symptoms that overlap, making it challenging to pinpoint what might be affecting my health. Let's break down my situation: - Age: 25 years, Gender: Female, Height: 5’1”, Weight: 125 lbs. - The last menstruation occurred in June 2024. Prior to this, my menstrual cycle was remarkably consistent since I was around 12 years old, typically without severe premenstrual symptoms, heavy flow, or irregularities. - Various blood tests over time reveal that most hormone levels fall within normal ranges, with the exception of estradiol (persistently between 10-20) and progesterone (remaining below 0.2). - A couple of results raised some concerns for me personally, even if my doctors weren’t alarmed: my morning cortisol was measured at 13.4 and in the afternoon at 9.49. One test indicated a TSH level of 2.35, which increased to 3.93 months later. My fasting glucose consistently hovers around 80, whereas random glucose levels were recorded at 68, and postprandial glucose was 65. - An MRI indicated a "deviation of the pituitary stalk, potentially linked to a small pituitary adenoma." - An ultrasound revealed "multiple oval, well-defined, anechoic images with posterior acoustic enhancement, measuring a few millimeters, located around the edges of the stroma." - The symptoms I am experiencing include disrupted sleep (frequent awakenings, particularly around 3 AM, making it hard to resume sleep), lack of energy, difficulty in weight management, persistent hunger, heightened anxiety, and hair thinning. - Birth control (drospirenone and ethinyl estradiol) exacerbated nearly all of my symptoms, leading me to discontinue use after two weeks despite experiencing a withdrawal bleed. - My lifestyle is generally healthy; I consume a lot of whole foods, engage in weightlifting, and run regularly. Given that I’ve received a diagnosis of PCOS, I’m wondering if this assessment seems accurate. What options do I have moving forward, especially since the contraceptive method didn’t provide relief and I appear to exhibit signs of additional complications such as thyroid issues or cortisol dysregulation?

LupusThyroid DisordersEndocrinology
Male25-34
1 hour ago