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Exploring a Conundrum: Seeking Insights

12/16/2025, 7:40:26 PMMale25-34

Patient Background: - Male, 47 years old - Weight: 78 kg - Height: 180 cm - Engages in a physically active routine, working out about 4.5 to 5 hours weekly - History of lymphatic tuberculosis at age 15 - Diagnosed with hypercholesterolemia - Presence of nasal polyps - Does not smoke - Alcohol consumption: 4-6 units per week Symptoms Presented: - Noticeable swelling in both armpit lymph nodes; they are movable, soft to the touch, and not painful. - Absence of fever, night sweats, or feelings of exhaustion - CRP level is under 1 - SPEP results are negative - Testing for HIV and Hepatitis B and C returned negative results - Syphilis test likely false positive, with one weak positive treponemal test along with three negative treponemal tests and one non-treponemal test returning negative - No signs of anemia - Iron levels are within normal range Seeking Advice: I’ve been contemplating what could be causing these symptoms. There’s a referral in place for an ultrasound of the lymph nodes, which should occur shortly. However, I’d appreciate your insights on potential underlying issues. I have concerns about the possibility of lymphoma or another solid tumor, such as lung cancer that might have metastasized to the axillary lymph nodes, although the low CRP level is somewhat reassuring. There could also be an autoimmune condition at play. What are your thoughts, and what further tests would you advise? Thank you for your input!

Crohn's DiseaseThyroid DisordersRheumatology

Answers (1)

Cony

12/16/2025, 7:40:45 PM

OpenHealth AI

Thank you for sharing your concerns and detailed background. The swollen lymph nodes you're experiencing, combined with your health history and current health indicators, present a complex situation, but there are several possibilities that could explain your symptoms.

Key Points to Consider

  • Swollen lymph nodes, especially when they are soft and movable without accompanying painful symptoms or systemic signs like fever, can be due to various benign causes. They often signify a response to infections or other non-cancerous conditions.
  • Your levels of CRP being under 1 indicate low levels of inflammation, which is somewhat reassuring and often seen in non-malignant conditions.
  • The various negative test results suggest that your immune system is not responding to significant infections at this moment.

Potential Causes and Explanations

  1. Infections: Previous viral or bacterial infections can lead to temporary lymph node swelling. If this is the case, the nodes may gradually reduce in size.
  2. Nasal Polyps: Having nasal polyps can sometimes lead to regional lymph node enlargement due to local inflammation or infection.
  3. Autoimmune Conditions: Conditions like lupus or others could lead to lymphadenopathy, but these usually present with additional symptoms (which you currently do not have).
  4. Malignancies: While your concerns about lymphoma or metastasis are valid given the signs, the likelihood is reduced given your low CRP levels and negative infectious workup.

Next Steps to Consider

  1. Ultrasound: Await the ultrasound of your lymph nodes, as this will help provide more information on their characteristics and if further investigations are necessary.
  2. Monitor Changes: Observe any changes in the swelling, such as a change in size, texture, and if new symptoms emerge (like fever, weight loss, fatigue) over the next few weeks.
  3. Maintain Open Dialogue with Your Healthcare Providers: Continue discussing your concerns and any findings from the ultrasound with your doctor. They may recommend additional tests based on the ultrasound findings.
  4. Consider Regular Follow-ups: Schedule periodic checks to monitor any persistent or new symptoms and changes in your condition, ensuring you are always informed and proactive about your health needs.

Reassurance

It’s understandable to feel anxious given your symptoms, especially with your history of lymphatic tuberculosis. However, many cases of lymph node swelling are benign and resolve on their own. Your proactive approach to health and timely investigation through ultrasound is essential in managing your worries and ensuring your well-being. Please keep me updated on your progress, and don’t hesitate to reach out with more questions as you proceed through this situation.

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