Concerns About Rexulti and Seizures
For the past five years, I have been on Rexulti, in addition to seven other medications. My seizures stem from a traumatic brain injury (TBI), and despite my treatment plan, I still experience over a dozen seizures annually. Recently, I came across information indicating that Rexulti (brexpiprazole) may heighten the likelihood of seizures, particularly in individuals with pre-existing seizure conditions or factors that can diminish seizure thresholds like head trauma, alcohol dependence, or central nervous system issues. I'm now faced with how to approach my doctor about this concern. I value our relationship and don’t want to upset her, especially since she has previously advised me to be cautious about the reliability of information sourced from the internet. However, I genuinely believe that this medication may be contributing to my ongoing seizures. To provide some background about myself, I’m a 37-year-old Caucasian male residing in Detroit, standing at 5’8” and weighing 190 pounds. My medical history includes diagnoses of TBI, PTSD, major depressive disorder, epilepsy, and bipolar disorder. Currently, my medication regimen includes gabapentin, klonopin, trileptal, adderall, hydroxyzine, and Rexulti, along with occasional marijuana use.
Answers (1)
9/15/2025, 12:31:03 PM
OpenHealth AI
It's understandable to be concerned about the potential impact of Rexulti on your seizure activity, especially considering your history with a traumatic brain injury and ongoing epilepsy. Addressing these concerns with your doctor is important, as they can provide personalized guidance based on your unique medical history.
Explanation:
Rexulti (brexpiprazole) is an antipsychotic that can potentially lower the seizure threshold, making seizures more likely in some individuals. Given your history of TBI and epilepsy, it is sensible to question whether it's contributing to your ongoing seizure episodes. It’s essential to discuss both your concerns and your seizures openly with your healthcare provider, as they can evaluate the risks and benefits of your current medication regimen.
Next Steps:
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Prepare for Your Appointment:
- Write down your concerns about Rexulti and how you believe it may affect your seizures. Note any changes in seizure patterns since starting the medication.
- Bring a log of your recent seizure events, including dates, durations, and any potential triggers.
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Open the Conversation:
- Approach your doctor by expressing your trust in their expertise but your need to understand more about your treatment. You could say, "I have some concerns regarding Rexulti and its potential impact on my seizures given my background with TBI and epilepsy, and I’d like to know your thoughts on this."
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Discuss Alternatives:
- If it is confirmed that Rexulti may be linked to your seizures, ask about alternative medications that may not have the same risk and explore any necessary adjustments to your treatment plan.
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Monitor Symptoms:
- Continue to track your seizures, medication effects, and any side effects you experience. This diary can provide useful information for your doctor to make informed decisions.
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Consider Support:
- If you're feeling anxious about this discussion, consider bringing a family member or friend along to support you during your appointment.
Your proactive approach to your health and medication is commendable, and your concerns are valid. Ensuring you have a clear channel of communication with your doctor will help you make informed decisions and find the best treatment path moving forward.
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