Are First-Generation Antipsychotics Truly That Dangerous? (Long-Term Consequences)
Profile: F26, Height: 164 cm, Weight: 57 kg, Diagnoses include ADHD, autism, depression, and anxiety disorders. I often experience intense mood fluctuations. My emotions can swing dramatically, fluctuating from a calm state to feelings of despair within a single hour, only to later feel energized and dancing to music. My body did not react well to SSRIs or NDRIs like Wellbutrin. These medications caused excessive sweating, disrupted my body temperature regulation, and left me feeling more fatigued than before I started them. Conversely, I found relief with Deanxit, which combines melitracen (a tricyclic antidepressant) with flupentixol, a first-generation antipsychotic. The recommendation is to limit its use to no more than 14 days due to potential risks associated with antipsychotics, such as nerve damage leading to conditions like Parkinson’s disease or dyskinesia—the latter being a side effect I want to avoid at all costs. From my understanding, the risk for long-term effects increases with prolonged use and higher doses of these medications. This raises the question: Are these first-generation antipsychotics as harmful as they seem? If someone is not suffering from psychosis, schizophrenia, or bipolar disorder, is it truly necessary for them to use these medications? Are there viable alternatives available? I’m uncertain which of the two medications contributes more to my stability, but I do observe they act quickly; I don’t have to wait a month as I do with many other antidepressants.
Answers (1)
9/14/2025, 3:30:57 PM
OpenHealth AI
First-generation antipsychotics, like flupentixol, can indeed raise concerns about long-term use, particularly regarding side effects such as movement disorders. However, their role and effects can vary significantly from person to person. It's understandable to have concerns, especially given your previous experiences with other medications. Let's break it down and explore your options.
Key Points:
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Risks of First-Generation Antipsychotics: Long-term use can lead to side effects such as tardive dyskinesia (involuntary movements) and other neurological issues. The risk does tend to increase with higher doses and prolonged treatment.
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Benefits of Immediate Relief: You mentioned that Deanxit provides quick relief for your mood swings. This is a valid consideration, especially when other medications have not worked for you.
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Alternatives: There are other treatment options that could be less risky while still helping to manage your symptoms effectively.
Explanation:
First-generation antipsychotics are typically used in the treatment of severe mental illnesses like schizophrenia. They can be effective in stabilizing mood, but they carry a risk of serious side effects, particularly with long-term use. Since you do not have a diagnosis of those more severe conditions, the necessity of such medications can be scrutinized.
Your own observations on how quickly Deanxit works for you are significant; some individuals find that these medications manage their symptoms effectively despite the associated risks. However, it’s essential to weigh these benefits against potential long-term consequences.
Next Steps:
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Monitor Your Symptoms: Keep a detailed record of your mood changes, how you feel with Deanxit, and any side effects you notice. This will be helpful in evaluating treatment effectiveness.
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Consider Alternatives: Discuss with your healthcare provider alternatives like mood stabilizers, certain antidepressants, or even psychosocial therapies (like cognitive behavioral therapy) that can offer support without the high risk of movement disorders.
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Regular Check-ins: If you decide to continue with Deanxit or any other medication, plan regular check-ins (e.g., every 2-4 weeks) with your healthcare provider to assess the balance between benefits and potential side effects.
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Lifestyle Factors: Focus on lifestyle modifications such as regular exercise, a balanced diet, sufficient sleep, and mindfulness practices (like meditation) that may help stabilize your mood naturally alongside any medication.
It's crucial to have an open dialogue with your healthcare provider about your concerns and to establish a treatment plan that feels safe and supportive for you. Let me know if you’d like to explore more options or need additional information.
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