Understanding Diffuse T Wave Changes
Subject: 19 years old, Female, 5’5", weight 135 lbs. Currently, I’m not taking any medications, although I previously used Seroquel in doses ranging from 25 to 100 mg to assist with sleep. Last November, I underwent an ECG, which revealed diffuse T wave inversions across all leads, excluding leads I, aVR, and V1. I have had an echocardiogram that confirmed there are no structural issues with my heart. Additionally, I wore a Holter monitor for 72 hours that recorded a sinus rhythm with a mean heart rate of 80 bpm, showing nonspecific T wave alterations throughout the monitoring period. A stress test was also administered, which indicated no ischemic changes during exertion. Over the past year, I have had four ECGs, all yielding similar results, the latest being conducted just last week. I am aware that T wave alterations can sometimes be benign variations. Notably, I had an ECG back in 2021 that showed no ST segment changes. At present, I do not experience chest pain or shortness of breath; however, I occasionally feel palpitations—about one to three times every five days, each lasting less than a second. I have been advised to check my electrolyte levels; however, my cardiologist remains skeptical that this could be related to any electrolyte imbalance. He has scheduled a follow-up echo and ECG for a year from now, explaining that these tests may provide insight into potential structural changes that could indicate future cardiomyopathy. I do not have a family history of this condition and I previously vaped, but I stopped approximately ten months ago. If anyone has advice on further steps or insights into my situation, I welcome your input!
Answers (1)

9/9/2025, 7:20:45 PM
OpenHealth AI
It sounds like you’ve been closely monitored for your heart health, and it's understandable to have questions about your ECG results and any associated symptoms. Your findings reveal persistently inverted T waves, yet numerous tests have ruled out significant structural heart issues. Here’s a summary and guidance based on the information you provided:
Main Points:
- Diffuse T Wave Inversion: While often benign, persistent T wave inversions can be a cause for investigation.
- Cardiac Evaluations: You've had multiple tests that suggest no serious underlying heart conditions.
- Symptoms: Palpitations are common and may not be related to the T wave findings.
Explanation:
- T Wave Changes: Diffuse T wave inversions can occur due to various reasons, like normal anatomical variations, stress, electrolyte imbalances, or even effects from previous medications like Seroquel. Since you’ve had comprehensive tests (echo, Holter monitor, stress test) without identifying any structural heart problems, it is reassuring.
- Palpitations: Occasional palpitations lasting a second or less are frequently benign, particularly if you're not experiencing any other concerning symptoms like dizziness or chest pain.
Next Steps:
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Monitor Symptoms: Continue to keep a diary of your palpitations. Note their frequency, duration, and any potential triggers (like stress or caffeine). This can help identify patterns and inform future discussions with your cardiologist.
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Electrolyte Levels: Follow through with checking your electrolyte levels as suggested. Maintaining a balanced diet rich in potassium, magnesium, and calcium can be beneficial.
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Lifestyle Modifications: Ensure you maintain a healthy lifestyle — stay hydrated, eat well, manage stress through techniques like mindfulness or yoga, and avoid stimulants (caffeine, nicotine) that can aggravate palpitations.
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Regular Follow-ups: Follow your cardiologist's plan regarding future ECGs and echo tests. If at any point your symptoms change (e.g., increased frequency of palpitations, new symptoms), make sure to communicate these with your doctor.
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Stay Informed: Continue to educate yourself about your condition and engage actively in discussions with your healthcare providers.
Reassurance:
It’s excellent that you are engaged and proactive about your heart health. Many individuals with similar ECG findings go on to lead healthy lives without significant issues. If you have any further concerns, please reach out to your healthcare provider. You're taking the right steps by monitoring your health and seeking information!
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