Should I Request a Retest for 17-OHP?
I underwent testing for 17-hydroxyprogesterone (17-OHP) to eliminate the possibility of non-classical adrenal hyperplasia (NCAH), but I suspect the timing may not have been ideal. The test was conducted at 3 PM on the 16th day of my cycle, while I've read that it’s preferable to perform this test in the early morning during days 3 to 5 of the cycle. I'm aware that hormone levels can fluctuate throughout the day, but I'm uncertain about the extent of that variation. Additionally, I believe I was still in the follicular phase at the time of the test, with ovulation projected around day 19 in my 33-day cycle. Would it be prudent to have the test redone? If so, should I pursue a referral to an endocrinologist or go through my general practitioner? My results showed a level of 2.5 nmol/L. According to the NHS, the reference ranges are as follows: - Follicular phase: 0.4-3.6 nmol/L - Luteal phase: 1.2-7.6 nmol/L To provide some context about myself: - I am 21 years old - Female - 171 cm (5'7") tall - Weighing 65 kg (143 lbs) - White British background - Not currently on any medications - Abstain from alcohol, smoking, and recreational drugs Is a retest advisable? If that’s the case, should I seek a consultation with an endocrinologist or simply liaise with my GP?
Answers (1)
9/7/2025, 7:01:24 PM
OpenHealth AI
Given your concerns about the timing of your 17-hydroxyprogesterone (17-OHP) test, it’s understandable that you're considering a retest. Hormone levels can indeed fluctuate depending on the time of day and the phase of the menstrual cycle, which may impact the accuracy of your test results.
Key Points to Consider:
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Timing of the Test: You are correct that 17-OHP testing is typically more reliable when conducted in the early morning during the early follicular phase (days 3 to 5 of the menstrual cycle). Conducting it in the afternoon may not provide the most accurate representation of your hormone levels.
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Your Test Result: Your level of 2.5 nmol/L falls within the expected range for the follicular phase, but being on the higher end may warrant further investigation, especially since you've experienced concerns related to NCAH.
Explanation:
Hormone levels like 17-OHP can vary significantly throughout the day and across different phases of the menstrual cycle. Testing during a peak period (i.e., shortly before ovulation) might not give a clear picture of baseline hormone levels. Given your test was done later in the cycle, you may want to retest to ensure conclusive results.
Next Steps:
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Consider a Retest: Yes, it would be prudent to have the 17-OHP test redone, particularly in the morning during the first week of your cycle (preferably days 3 to 5). This will provide a more accurate assessment of your hormonal status.
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Consult Your GP: Start by discussing your concerns and the desire for a retest with your general practitioner (GP). They can order the test and provide you with the appropriate referrals if needed.
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Plan for Follow-Up: After receiving your retest results, if there are still concerns about NCAH or other hormonal issues, your GP can then refer you to an endocrinologist for further evaluation and management.
Remember, testing for hormone levels is just one part of understanding your health, and ongoing communication with your healthcare provider is crucial. If you have more questions or need additional information regarding the retest process, feel free to ask.
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