Understanding My Experience with Mycoplasma Genitalium
I am a 24-year-old man who recently encountered some troubling health issues related to my girlfriend's discomfort. Towards the end of July, she experienced some symptoms that prompted me to encourage her to visit a healthcare facility. Upon her arrival at the clinic, the medical staff informed her that she had a sexually transmitted infection (STI), although no diagnostic tests were conducted; the diagnosis was solely based on her symptoms. Out of concern, I decided to check myself and discovered an unusual white lesion situated near my urethra. Surprisingly, I was not experiencing any pain or discomfort at that time. Subsequently, I consulted my general practitioner, explaining my girlfriend's STI diagnosis. After examining me, he also noted the abnormality at my urethra and concluded that I, too, had an STI. Again, no tests were performed, but he prescribed me a course of ceftriaxone, metronidazole (Flagyl), and doxycycline for a week. Thankfully, after completing the medication, the lesion seemed to disappear. A few weeks later, my girlfriend visited again, and we engaged in unprotected sexual intercourse. Unfortunately, after her departure, I observed the return of the abnormality in my urethra. This prompted me to seek a second opinion from a different physician, who agreed to conduct comprehensive testing this time. Following a full blood evaluation and urinalysis, I received a positive diagnosis for Mycoplasma genitalium. The new doctor prescribed ceftriaxone again alongside metronidazole and introduced moxifloxacin, which I was instructed to take once a day for five days, with a follow-up appointment scheduled for a week later if symptoms persisted. Upon my return after the week, I shared the lack of improvement in my condition, and my doctor repeated the prescription of ceftriaxone, metronidazole, and doxycycline but at a higher frequency – twice a day for another seven days. As I finish this course of doxycycline, I still have not noticed any changes. I am reaching out in hopes of obtaining some guidance or suggestions regarding my situation.
Answers (1)

9/7/2025, 6:01:48 PM
OpenHealth AI
It sounds like you are dealing with a challenging situation related to a Mycoplasma genitalium diagnosis, and it's understandable to seek clarity and guidance. Here are some key points to consider and next steps to help manage your condition and symptoms effectively.
Summary of Key Points
- You have been diagnosed with Mycoplasma genitalium after experiencing persistent symptoms, despite several courses of antibiotics.
- The treatments you have received include ceftriaxone, metronidazole, and doxycycline, yet you have not seen the desired improvement.
- Ongoing symptoms can be frustrating and require further attention to ensure effective management.
Explanation
Mycoplasma genitalium is an STI that can be tricky to treat due to its resistance to certain antibiotics. The antibiotics you've taken are commonly prescribed for this infection, but not all strains of the bacteria respond to them the same way. If symptoms persist after completing antibiotic treatments, it's essential to address these concerns with your doctor thoroughly.
Actionable Next Steps
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Return to Your Healthcare Provider:
- Schedule a follow-up appointment with your healthcare provider to discuss your lack of improvement. Prepare for this visit by documenting any new or persistent symptoms.
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Request Further Testing:
- Ask about sensitivity testing to determine which antibiotics would be most effective for your specific mycoplasma strain. This test can help identify the most appropriate treatment options.
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Consider Partner Testing and Treatment:
- Ensure your girlfriend is also receiving appropriate care. Since STIs can be transmitted between partners, it may be essential for her to undergo testing and potentially receive treatment concurrently.
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Practice Safe Sex:
- Until you have confirmed that the infection has been adequately treated, consider using barrier methods (like condoms) during sexual activity to prevent further transmission.
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Monitor Symptoms:
- Keep a symptom diary tracking any changes, new lesions, or discomfort. This information will be valuable for your healthcare provider to assess your condition.
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Educate Yourself:
- Learn more about Mycoplasma genitalium through reputable sources, such as the CDC or WHO, to better understand the infection, treatment options, and management strategies.
Reassurance
It's understandable to feel frustrated and concerned about your ongoing symptoms. These steps aim to streamline your recovery process and provide the best possibility for resolution. You're proactively seeking help, which is commendable, and it's important to keep an open line of communication with your healthcare team moving forward.
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