Seeking Advice on Bulging Veins Related to AS and Treatment
Greetings everyone, I’m reaching out for some guidance regarding recurrent bulging veins that are quite noticeable on my legs. At 33, I’ve been diagnosed with Ankylosing Spondylitis (AS). My condition includes significant nerve involvement due to my autoimmune disease alongside a few discs that are pressing against the thecal sac. I engage in some light exercises, primarily focusing on stretching and walking for cardio, but it’s not extensive. Currently, my medication regimen consists of 50mg of etanercept administered weekly, along with methotrexate dosages that vary between 5mg and 7.5mg each week. Additionally, I have been on prednisone for a few months now. Fortunately, my blood pressure readings are within normal limits, and both my liver and kidneys appear to be functioning well. I am also undergoing testosterone replacement therapy (TRT) and utilizing HCG to help maintain my fertility. I suspect that this recent development—occurring over the past couple of months—may be linked to the TRT, as these bulging veins tend to fluctuate significantly. They seem to worsen when I adjust my testosterone or HCG doses. Given these circumstances, I’m curious if reducing or pausing my TRT, along with beginning PCT and HCG, might alleviate these vein issues while also addressing my low testosterone levels. I will post pictures in the comments to illustrate the severity of the situation. Any advice or insights would be greatly appreciated. Thanks in advance for your responses!
Answers (1)

9/5/2025, 1:50:40 PM
OpenHealth AI
Main Points:
It sounds like you’re experiencing noticeable bulging veins in your legs, and you suspect that changes in your testosterone replacement therapy (TRT) may be contributing to this issue. Given your background with Ankylosing Spondylitis (AS) and other medications, it's important to approach this carefully.
Explanation:
Bulging veins can occur for various reasons, and they may be linked to blood flow or increased pressure in the veins. In your case, several factors could be playing a role:
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TRT and Hormones: Testosterone can influence fluid retention and vascular changes, which might explain the fluctuations in the appearance of the veins. If recent adjustments in your TRT have coincided with the worsening of vein prominence, this could indeed be a factor.
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Exercise and Positioning: While you engage in light exercise, prolonged sitting or standing, or specific exercises can cause veins to bulge.
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Autoimmune Condition: Your diagnosis of AS could contribute to changes in circulation or tissue integrity, although this is less direct.
Next Steps:
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Monitor Changes: Keep a detailed record of how your vein prominence changes in relation to your TRT doses and activities. Note any accompanying symptoms (like pain or swelling), which can help identify patterns.
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Consider Dose Adjustments: It may be worth discussing a temporary reduction or pause of your TRT or HCG therapy with your healthcare provider. This should ideally be done under professional supervision to monitor both your hormone levels and symptoms closely.
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Review with a Specialist: Considering the complexity of your condition, seek guidance from both your endocrinologist regarding TRT and your rheumatologist for AS. They can provide tailored advice that considers both your hormone levels and joint health.
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Increase Leg Exercise: Incorporate regular leg exercises that promote circulation, such as gentle leg raises and calf stretches, which may help alleviate some of the vein bulging. Avoid prolonged periods of sitting or standing if possible.
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Compression Stockings: If bulging veins become bothersome, consider using compression stockings, which can help support vein health and reduce swelling.
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Hydration and Weight Management: Maintaining a healthy weight and ensuring adequate hydration can also support vascular health.
Taking these steps can help manage your symptoms more effectively. Please let me know if you have further questions or want more specific details regarding any points!
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