Understanding High C-Reactive Protein Levels
At the age of 43, I find myself grappling with some alarming health issues. As a male with type 2 diabetes, I am on medications including Metformin, Jardiance, Ozempic, and Glimepiride. Recently, I’ve endured three weeks of persistent illness, marked by fever and headaches that were effectively alleviated by Tylenol and Motrin. However, my condition escalated to severe muscle pain affecting my quadriceps, hamstrings, and calves, alongside ongoing headaches and a low-grade fever. After seeking care, I was tested for flu and COVID-19 at an urgent care facility, but both results were negative. Three days later, despite a lack of energy and similar symptoms, I visited the emergency room. A series of blood tests were conducted, and thankfully, no abnormalities were detected, suggesting I might be dealing with a viral infection. My primary care physician, during a follow-up, requested tests for Lyme disease and spotted fever; those results were negative. However, a concerning CRP level of 214 was revealed. Despite the lingering muscle aches, fatigue, and slight fever, my doctor advised me to retest my CRP levels in a month and referred me to a rheumatologist, with an appointment scheduled for September 18th. I’m feeling quite uncertain about this plan and whether it’s a reasonable approach. I’m reinstating my work responsibilities shortly, yet I’m anxious about managing without relying heavily on Motrin. Should I consider pushing for another appointment with my PCP to discuss this further? Is it advisable to simply wait this out? For context, I currently weigh approximately 160 pounds, reflecting a decrease of around seven pounds throughout this ordeal. My diabetes is somewhat controlled, with my latest A1C reading at 6.3.
Answers (1)

9/2/2025, 9:20:40 PM
OpenHealth AI
It's understandable to feel uncertain and anxious given your recent health challenges and elevated C-reactive protein (CRP) levels. Your concern is valid as high CRP can indicate inflammation in the body, and managing your symptoms while considering your diabetes and upcoming work responsibilities is important.
Explanation of Your Situation
CRP is a substance produced by the liver in response to inflammation. A level of 214 is elevated, indicating a significant inflammatory response, but it's essential to understand that CRP is a non-specific marker; it doesn't pinpoint the exact cause. Your recent symptoms and the negative tests for flu, COVID-19, Lyme disease, and spotted fever suggest that you might be dealing with a viral infection or another inflammatory condition.
Next Steps
Here are some prioritized actions you can consider:
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Monitor Symptoms: Keep track of any changes in your symptoms, particularly any new symptoms or changes in fever. Note how your energy levels fluctuate and any changes in muscle pain. This information is helpful for your follow-up appointments.
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Rest and Recovery: Prioritize rest to help your body recover. While it might be tempting to jump back into work, ensure you're feeling better and have more energy before fully resuming responsibilities.
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Medication Management: If you're concerned about over-relying on Motrin (ibuprofen), consider alternating it with Tylenol (acetaminophen) for pain relief as needed, but be mindful of the total allowed dosage for both.
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Stay Hydrated and Eat Well: Focus on staying well-hydrated and eating balanced meals, which can support your recovery. Include plenty of fruits, vegetables, lean proteins, and whole grains.
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Follow-Up with Your PCP: If symptoms persist or worsen before your rheumatology appointment, or if you feel uncertain about your current approach, reaching out to your primary care physician for an earlier discussion can provide clarity and reassurance.
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Prepare for Your Rheumatology Appointment: Gather your symptom diary and any questions you have for the rheumatologist. This will help ensure you address all your concerns during the appointment.
Conclusion
Acknowledging your anxiety is important, and your proactive approach is commendable. While it's reasonable to wait for your rheumatology appointment, keeping an eye on symptom changes and maintaining communication with your healthcare providers is essential. Take steps toward a paced recovery and communicate any concerns that arise before your next visit.
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