Evaluating the Risks of Terbinafine: What to Expect at a Clinic or Emergency Room
At 45 years old, standing at 6 feet 3 inches tall and weighing 172 pounds, I maintain a lifestyle that avoids alcohol, smoking, and drugs while not taking any medications. For nearly ten years, I have been managing a persistent fungal infection affecting both my fingernails and toenails. It all began around a decade ago when my right middle fingernail showed severe signs of the infection. After visiting the ER, medical staff lanced that nail, which significantly improved its condition, allowing it to regrow without further issues. Despite this, I continue to struggle with the infection on two of my fingernails and several toenails. Throughout this period, I primarily received topical treatments, particularly ciclopirox. While it hasn’t eradicated the infection, it has helped to some extent in controlling its spread. The condition of my nails has deteriorated, making them fragile. To manage any active infection on a new nail, I usually resort to peeling the affected areas off. Last Fall, I consulted a new physician who prescribed terbinafine. However, after conducting some research, I found alarming information regarding its potential negative effects on the liver. Additionally, numerous users on Reddit express concerns about experiencing depression and suicidal ideation after starting the medication. These findings made me hesitant to follow through with taking the prescribed drug. Instead, I opted to try a homemade remedy suggested by a friend, which involved coconut oil and oregano oil. Unfortunately, during this time, I neglected to apply ciclopirox as well. Recently, an infection has developed under the nail of my left thumb, complicating my efforts to remove the infected area. This situation has caused the nail to lift visibly. I have a couple of questions: 1) What is your perspective on the severity of the side effects associated with terbinafine? 2) Should I visit a walk-in clinic or emergency room, what treatment methods might they employ? Would they consider lancing the fingernail again? I’ve read conflicting information online, some suggesting that lancing is only performed if pus is present, but I believe there's significant infection beneath my nail. I appreciate your time and insight on these matters!
Answers (1)

9/2/2025, 1:20:50 PM
OpenHealth AI
Thank you for sharing your concerns about your persistent nail fungal infection and the potential use of terbinafine. Let’s address your questions and situation step by step.
Key Points
- Side Effects of Terbinafine: While terbinafine can have side effects, including liver issues and psychological effects, these are not universally experienced and need to be balanced with the benefits it may provide.
- Deciding Between Clinic and Emergency Room: If you have a visible infection and significant discomfort, seeking treatment promptly is crucial. You might favor a walk-in clinic unless your symptoms worsen significantly.
Explanation
1. Risks of Terbinafine: While liver toxicity is a potential concern with terbinafine, this risk is generally low when the medication is used as directed, especially in healthy individuals without pre-existing liver conditions. Most side effects are mild, and psychological effects like depression are rare. It is essential to weigh these risks against the potential benefits, especially since your fungal infection has been persistent. Consulting a doctor about these specific concerns can provide personalized reassurance.
2. When to Visit a Clinic or Emergency Room: Given that you have developed an infection under your thumb nail, which is causing lifting and visible discomfort, it’s advisable to seek medical attention soon. A walk-in clinic can address your concerns, and they are equipped to handle nail infections. Here’s what you can expect:
- Diagnosis: The healthcare provider will examine the affected nail area for signs of infection.
- Treatment Options: If there is significant infection visible, they may consider lancing the nail, especially if there is liquid forming beneath it. While lancing is often performed when pus is present, it's about relieving pressure and allowing drainage, which may be warranted due to your symptoms.
- Additional Treatments: They might also prescribe antifungal treatments (oral or topical) other than terbinafine, if necessary, depending on their assessment.
Next Steps
- Seek Medical Attention: Consider visiting a walk-in clinic soon, especially since the infection appears to be worsening. Immediate intervention could help prevent further complications.
- Document Symptoms: Take note of any additional symptoms (pain level, changes in color, or swelling) that you can share with the healthcare provider. This information can aid in their assessment.
- Discuss Treatment Options: Communicate your concerns about terbinafine with the healthcare provider. They can discuss alternative antifungal medications or re-evaluate the necessity of lancing based on your condition.
- Implement Basic Nail Care: While waiting for your appointment, continue to keep your nails clean and dry, and avoid further peeling, as this can worsen the infection.
Thank you for your patience as we navigate your health concerns. Your proactive approach is commendable, and seeking guidance at this stage is a beneficial step forward. Please let me know if you have more questions or need further clarification!
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