33-Year-Old Male - Electrophoresis and Blood Test Results
Greetings! Recently, my hematologist recommended that I undergo an electrophoresis serum test, specifically a reflex immunofixation electrophoresis (IFE). The results revealed a total protein level of 7.4 g/dL, with an albumin of 4.9 g/dL. The globulin breakdown showed that alpha 1 globulin measured at 0.2 g/dL, alpha 2 globulin at 0.5 g/dL, beta 1 at 0.7 g/dL, and gamma globulin at 1.1 g/dL. Notably, there was no M-spike identified, with the total globulin amounting to 2.5 g/dL, resulting in an albumin/globulin (A/G) ratio of 2. Over the past two years, I’ve experienced a gradual decrease in my white blood cell count, which currently stands at 2.45. Additionally, my absolute neutrophil count has also been low, recorded at 1.19. In response to these concerns, my hematologist ordered several blood tests, and thankfully, all of them returned normal results. However, one of the cancer screening tests indicated a 0.7% blast count related to leukemia or lymphoma, but the hematologist reassured me that everything else appeared normal and advised that I shouldn't be overly concerned about the blast percentage. Lately, I've been experiencing intermittent fatigue, along with discomfort in my hips and lower back, and I’ve developed a few sores in my mouth. Currently, I’m trying to understand what might be causing these symptoms. Should I be worried about the A/G ratio being somewhat elevated? Any insights or advice would be immensely appreciated. Thank you!
Answers (1)
8/30/2025, 12:43:51 AM
OpenHealth AI
Thank you for sharing your detailed health information. Your concerns about your test results and symptoms are valid, and I'm here to help you understand them better.
Key Points:
- The electrophoresis results show no significant abnormalities such as an M-spike or issues with your total protein and A/G ratio.
- Your low white blood cell and neutrophil counts, along with intermittent fatigue and other symptoms, can have various causes.
- The presence of a low blast count may be less alarming, as your hematologist suggested, but monitoring is crucial.
Explanation:
From the information you've provided:
- Total Protein and A/G Ratio: Your total protein level (7.4 g/dL) and A/G ratio (2) are generally within normal ranges. An elevated A/G ratio might indicate conditions where there is high albumin relative to globulin, but in your case, it seems stable.
- Low White Blood Cell Count: Your white blood cell count (2.45) and low neutrophils (1.19) can make you more susceptible to infections and fatigue. Low counts can stem from various factors, including autoimmune issues, bone marrow problems, or even nutritional deficiencies.
- Symptoms: Intermittent fatigue, hip and lower back discomfort, and mouth sores can be related to multiple factors such as infections, inflammatory processes, or even stress.
Next Steps:
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Monitor Symptoms: Keep a daily log of your symptoms, noting when they occur and how severe they are. This will help identify potential triggers or correlations with your activities.
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Rest and Hydration: Ensure you are getting enough rest and staying well-hydrated. Fatigue can be exacerbated by dehydration.
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Nutrition: Focus on a balanced diet rich in vitamins and minerals (especially iron, vitamin B12, and folate), which are essential for red blood cell and immune system production.
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Follow Up: Continue regular follow-ups with your hematologist. If your symptoms worsen or new ones appear (like fevers or significant weight loss), make sure to report those changes promptly.
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Consider Stress and Lifestyle Factors: Reflect on stress levels, sleep quality, and physical activity, as these can significantly impact your energy levels and overall health.
Although the results are largely reassuring at this point, it's essential to remain vigilant and work closely with your healthcare provider. If you're feeling uncertain or anxious about your condition, don't hesitate to seek further clarification with your hematologist. They can offer personalized insights tailored to your health journey.
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# 7-Month-Old Child with Abernethy Malformation - Exploring Treatment Options ## [7-Month-Old] Identified with Abernethy Malformation (Congenital Portosystemic Shunt) - Treatment Methods? **Age:** 7 months **Gender:** Female **Height:** Age-appropriate **Weight:** Currently 9 kg, was 2.8 kg at birth **Ethnicity:** Asian **Duration of Symptoms:** Present since birth **Location:** Uzbekistan **Pre-existing Health Issues:** Abernethy malformation (congenital portosystemic shunt), liver hemangiomas, chronic jaundice, anemia **Current Treatments:** Supportive management --- ## INITIAL PRESENTATION (June 2025 - July 2025) Our daughter arrived on **June 27, 2025**, presenting with: - Birth weight: **2.8 kg** - Marked jaundice (yellowing of skin and sclera) - Pale or clay-colored stools - **Bilirubin level: 245 μmol/L** (typically <20) An immediate ultrasound indicated multiple liver anomalies, initially thought to be hemangiomas. --- ## FIRST COMPREHENSIVE ASSESSMENT (August 1, 2025 - 1 Month Old) ### Multislice Computed Tomography (MSCT) with 3-Phase Contrast (August 1, 2025): **RESULTS:** - 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We are located in Uzbekistan but are prepared to travel (to Turkey, Russia, South Korea, etc.)** --- ## ADDITIONAL INFORMATION - No family history of hepatic diseases - Pregnancy and delivery were normal - No additional congenital defects identified - Immunizations up to date - No history of bleeding disorders - No signs indicative of encephalopathy - Child is alert and engaged --- **I can supply actual MSCT images and comprehensive lab reports if they would be of assistance.** We sincerely appreciate any insights you can provide. We are striving to make the most informed decision regarding our daughter’s care and highly value expert medical opinions. **TL;DR:** 7-month-old diagnosed with Abernethy Type 2 malformation (9.9 mm portocaval shunt, patent portal vein). Liver functionality is improving (normalized ALT) while bilirubin remains elevated (242). Evaluating options between endovascular coil embolization and open surgery. Seeking expert advice on optimal treatment strategy and timing.