Medication Inquiry
I am a 29-year-old woman with a history of complex regional pain syndrome and currently have a spinal cord stimulator implanted. Is it safe for me to combine 50 mg of Palexia with 5 mg of Diazepam? It’s currently 2:30 AM in my time zone, so experiencing drowsiness from the medication is not a concern for me. I took the Palexia at midnight to manage discomfort related to the spinal cord stimulator, but I am currently feeling somewhat anxious. Would it be appropriate for me to take the Diazepam now to help alleviate my anxiety and assist with sleep?
Answers (1)

8/27/2025, 4:42:49 PM
OpenHealth AI
Combining medications like Palexia (tapentadol) and Diazepam (a benzodiazepine) can be concerning due to the potential for increased sedation and respiratory depression. Given your medical history, it's important to handle medication combinations with caution.
Explanation
- Palexia (Tapentadol) is a pain reliever that affects the brain and nervous system; it can cause drowsiness and has a risk of dependence.
- Diazepam is commonly used for anxiety and can also cause sedation. When combined with opioids like Palexia, there's an elevated risk of excessive sedation, respiratory issues, and overdose.
Next Steps
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Consider Immediate Safety: If you have concerns about feeling overly sedated or having difficulty breathing after taking both medications, monitor yourself closely for any negative effects.
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Evaluate Symptoms: Since you took Palexia at midnight and are feeling anxious now, it’s essential to assess:
- Is this anxiety significantly impacting your ability to relax or sleep?
- Have you experienced any severe symptoms (e.g., shortness of breath, confusion)?
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Self-Care Techniques: Instead of taking Diazepam right now, consider some alternatives to help with anxiety:
- Deep Breathing: Try focusing on your breath; inhale deeply for four counts, hold for four counts, and exhale for four counts.
- Progressive Muscle Relaxation: Tense and then relax each muscle group, starting from your toes and working up to your head.
- Comfortable Environment: Create a calm space; dim lights, light a calming candle, or listen to soothing music.
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Future Considerations: If anxiety persists often after starting Palexia, it may be worth discussing this with your healthcare provider to evaluate your medication regimen.
Remember, your safety is the priority. If you decide to take Diazepam, please do so carefully, and ideally under the supervision of a healthcare provider in the future. If your anxiety feels overwhelming or if you experience unusual symptoms, seek medical help promptly.
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