Seeking Guidance for Ongoing Health Concerns
I'm looking for suggestions on what I should do next regarding my health situation. I'm a 41-year-old female experiencing intermittent joint pain, primarily affecting my elbows and wrists. I visited a rheumatologist in the past, and I've tested positive for IgA antibodies as well as HLA B 27. During episodes of discomfort, I notice elevated white blood cell counts alongside heightened absolute eosinophils. However, my rheumatoid factor has returned negative in multiple tests over the years. I continually hear that I meet some, but not all, criteria for a diagnosis, leaving me uncertain about where to turn or what queries to pursue in finding the underlying issue. I don't have any other apparent symptoms, such as rashes or fever. Any insights or recommendations would be greatly appreciated!
Answers (1)

8/8/2025, 4:11:00 AM
OpenHealth AI
It's understandable to feel uncertain and concerned about your ongoing joint pain and complex test results. Let's break down your situation to provide actionable steps forward.
Key Points:
- Your symptoms of intermittent joint pain, alongside positive IgA antibodies and HLA B 27, warrant attention but do not confirm a specific diagnosis since your rheumatoid factor has been negative.
- It's important to monitor symptoms and explore further diagnostic options to identify any underlying issues.
Explanation:
The presence of IgA antibodies and HLA B 27 can suggest certain autoimmune conditions, including ankylosing spondylitis or other spondyloarthritis types. However, the absence of other symptoms and negative rheumatoid factor complicate the picture. The elevated white blood cell and eosinophil counts could be indicators of inflammation but need further exploration to determine their significance.
Next Steps:
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Keep a Symptom Diary: Track your joint pain episodes, including duration, severity, and any activities or foods that may correlate with flare-ups. This can help identify triggers and facilitate your discussions with healthcare providers.
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Explore Additional Testing: Discuss with your healthcare provider the possibility of further tests like imaging studies (MRI or X-rays) or specific antibody tests to better understand your joint symptoms and rule out potential inflammatory conditions.
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Consult a Specialist: If you haven’t already, consider seeking a second opinion from another rheumatologist or a specialist in autoimmune diseases who can assess your symptoms and test results holistically.
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Manage Symptoms: In the interim, focus on pain management strategies such as:
- Gentle Exercise: Engage in low-impact activities like swimming or walking to keep joints mobile.
- Heat/Cold Therapy: Use heat to ease stiffness or cold packs to reduce inflammation during flare-ups.
- Anti-inflammatory Diet: Consider integrating foods known for their anti-inflammatory properties, such as fatty fish, leafy greens, nuts, and olive oil.
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Explore Support: Joining a support group can provide you with resources and shared experiences from others facing similar challenges, which can be comforting and informative.
Stay proactive about your health, and remember that understanding and addressing your symptoms may take time and continual collaboration with healthcare providers. If you have more questions or need further assistance, feel free to reach out!
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