Should I Be Concerned About My Reaction to Antibiotics?
Hi, I'm feeling quite anxious about my current situation and I'm uncertain if it's necessary to contact my physician. I’m a 25-year-old woman, currently taking 150 mg of extended-release Wellbutrin, 50 mg of Zoloft, along with a daily multivitamin, 250 mg of magnesium, and 5000 IU of vitamin D. Last Saturday, I was diagnosed with a kidney infection and was prescribed 1000 mg of cephalexin, to be taken twice daily. The burning sensation during urination and the presence of blood in my urine have resolved. However, I’ve been experiencing significant stomach discomfort. Eating anything has become painful, leading me to stick primarily to bananas and chicken noodle soup, as they seem to be the least irritating, although they still cause some discomfort. I tried consuming sauerkraut to introduce beneficial bacteria back into my gut, hoping it would alleviate the pain I’m feeling. The stomach pain began on Monday evening and intensified the following day. It was quite challenging, though not entirely unbearable, prompting frustrated tears. I’m finding today’s discomfort to be slightly improved, but it's still present. While I’m feeling hungry, I'm apprehensive about eating substantial meals due to the pain. Additionally, I’ve been experiencing considerable nausea daily since starting the antibiotic treatment. Is it common to experience stomach pain while on cephalexin? Could this be an indication that my kidney infection is worsening or possibly spreading? Or might it point towards a C. difficile infection? This entire ordeal is weighing heavily on my mind, and I’m genuinely concerned about worsening symptoms or the risk of developing C. diff.
Answers (1)

8/6/2025, 11:10:49 PM
OpenHealth AI
Experiencing stomach discomfort while taking antibiotics like cephalexin is not uncommon, but it can be concerning, especially when you're also dealing with other symptoms. Here's a breakdown of possible reasons for your discomfort and what you can do:
Main Points:
- Stomach discomfort can be a side effect of cephalexin.
- Your symptoms do not necessarily indicate a worsening kidney infection.
- Monitoring and managing your diet and symptoms is important.
Explanation:
Antibiotics can disrupt the balance of good bacteria in your gut, which may lead to stomach pain and nausea. While cephalexin is effective in treating bacterial infections, it can cause gastrointestinal side effects, including abdominal pain, nausea, and diarrhea. It’s also possible, though less common, to develop a Clostridium difficile (C. diff) infection, especially if you have had significant diarrhea or other gastrointestinal changes.
The fact that your burning sensation during urination and blood in your urine have resolved is a positive sign regarding the kidney infection. However, your current symptoms should still be taken seriously as they can impact your nutritional intake and overall recovery.
Next Steps:
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Hydration & Diet: Continue to prioritize hydration. Stick to bland foods, and focus on easily digestible options like bananas, rice, applesauce, and toast until your stomach settles. Avoid dairy, spicy foods, or anything overly greasy that may aggravate your discomfort.
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Monitor Symptoms: Keep an eye on your symptoms. If you notice any worsening abdominal pain, persistent nausea, diarrhea, or if you develop fever or blood in your stool, it would be advisable to reach out for medical attention.
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Timing of Medication: Take your antibiotics with food if you aren’t doing so already—this might help reduce stomach irritation. Discuss with a pharmacist or healthcare provider about timing your medications appropriately to minimize side effects.
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Probiotics: Instead of sauerkraut, consider taking a probiotic supplement (after checking it's compatible with your current medications) that contains specific strains known to help restore gut flora, which may also help alleviate some of your gastrointestinal discomfort.
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Relaxation Techniques: Since this situation is causing you anxiety, practicing relaxation techniques such as deep breathing or mindfulness might help reduce stress and improve your overall feeling of well-being.
If your symptoms persist or worsen, or if you have significant concerns about C. diff or other complications, please reach out to your healthcare provider. Your comfort and recovery are important, and they can give you the best advice tailored to your specific situation.
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