Understanding the Secondary Rash Following Hand, Foot, and Mouth Disease
Last Monday (July 28), my 4-year-old son woke up with a fever that left him feeling quite miserable, spiking as high as 104.9 degrees. He has a history of high fevers, so this wasn’t entirely unexpected. By Tuesday, he seemed to improve although he still had a low-grade fever. However, by Tuesday night, we observed some spots appearing on his hands and feet. A visit to the pediatrician on Wednesday confirmed our suspicions: he had contracted Hand, Foot, and Mouth Disease (HFMD). His symptoms were classic, featuring spots and blisters on his hands, feet, throat, and a few on his bottom. Our 1-year-old daughter caught a fever that same Wednesday afternoon and began developing spots by Thursday. Fortunately, by Friday evening, everyone was starting to recover, and my son was particularly on the upswing. Then came Saturday, when he developed a separate, concerning rash. It began on his back and neck, quickly spreading to his chest and abdomen as the day progressed. This rash has been incredibly itchy, causing him significant distress, with bouts of discomfort every 30 minutes to an hour. It appears red with tiny, rough bumps resembling chill bumps or chicken skin. Although it’s showing signs of improvement after five days, it still seems to irritate him significantly. He has a background of allergies and asthma, yet we can't pinpoint any triggers or new exposures that might have caused this reaction. The itchiness strikes him at the most random times, irrespective of his activities, clothing, food intake, or whether he’s indoors or outside. He describes the sensation as “small itchies” and points to various areas of his body that feel bothersome. Both our allergist and pediatrician are treating this as post-viral eczema, but I have doubts. We have never encountered a situation like this following a viral infection, especially one that has persisted for so long and has shown little improvement despite our efforts. We've tried almost everything: lotions, colloidal oatmeal baths, oatmeal soaks, baking soda baths, a 2.5% hydrocortisone cream, and even a three-day course of prednisolone. Despite our best efforts, relief remains elusive, and we're starting to feel overwhelmed. Has anyone experienced a similar rash following a viral illness? What can we try next, and will this ever resolve? Any guidance would be greatly appreciated!
Answers (1)

8/6/2025, 5:02:13 PM
OpenHealth AI
It sounds like your son is dealing with a very uncomfortable and distressing situation following his Hand, Foot, and Mouth Disease (HFMD). It’s understandable to feel overwhelmed, especially when treatments haven’t provided sufficient relief. While your healthcare providers suspect post-viral eczema, the characteristics of the rash and the itchiness are understandably concerning, especially since your son has a history of allergies and asthma.
Key Points:
- Post-Viral Eruption is Possible: Following HFMD or any viral illness, it's common for some children to develop a secondary rash or skin irritation. These can sometimes manifest like eczema or hives, especially in kids with a history of atopic conditions.
- Persistent Itching Needs Attention: While it can take time for skin issues post-viral illness to improve, your son's significant discomfort signals that additional steps might be necessary.
Explanation:
The rash you describe—red, itchy, with tiny bumps—might indeed be linked to his previous viral infection, or it could reflect a separate issue triggered by the stress on his body from the illness. The itchiness could be due to irritation, dryness, or an allergic response. Even common treatments can sometimes take a while to help, and what works for one child may not work for another.
Next Steps:
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Continue Moisturizing: Focus on applying a thick, fragrance-free moisturizer multiple times a day, especially after baths. Consider products with ceramides or specific eczema lotions recommended by dermatologists.
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Cold Compresses: When itching is severe, apply a cold compress to the affected areas for about 10-15 minutes. This can provide temporary relief from itchiness.
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Consider Antihistamines: Over-the-counter antihistamines like diphenhydramine (Benadryl) may help reduce itching, especially if taken before bedtime to enhance sleep. However, consult your pediatrician about dosage.
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Monitor for Triggers: Keep an eye out for potential irritants that may worsen his rash like soaps, detergents, or new materials in clothing. Since he has a history of allergies, a careful review of his environment and products may uncover possible triggers.
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Consult a Dermatologist: If the rash continues to cause significant discomfort or does not improve, consider scheduling an appointment with a pediatric dermatologist. They can offer specialized insight and alternative treatments, including prescription options such as stronger topical steroids or other medications.
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Document Symptoms: Keeping a daily log of the rash's appearance, timing, and any changes can provide valuable information for healthcare providers in tailoring the right treatment.
Reassurance:
While it's frustrating and concerning to see your child suffer from ongoing discomfort, many post-viral rashes resolve with time. Through consistent care and often through the right adjustments in treatment, relief is definitely possible. It’s important to stay engaged with your child's health team, and don't hesitate to seek help whenever necessary. Please feel free to reach out for further clarification or support.
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