Experiencing Withdrawal from Sulpiride
I'm a 20-year-old female with no significant health issues apart from experiencing anxiety and depression. Initially, I was prescribed Paroxetine at a dosage of 5 mg. As I began to acclimate to this medication, I noticed a reduction in my appetite, leading my doctor to recommend sulpiride at 50 mg to enhance my mood and stimulate my appetite. Unfortunately, after starting sulpiride, my appetite worsened, and my mood significantly declined. I discontinued its use after one week, specifically on the seventh day. Now, on the eleventh day since stopping the medication, I find myself feeling quite unwell. I continue to experience mild palpitations each morning, a persistent low mood, and my appetite has yet to return to its previous state. Prior to taking sulpiride, I was eating adequately and felt relatively stable. At this point, it seems that the medication has disrupted my well-being. Additionally, I've begun to notice occasional muscle jerks, which are quite alarming. Is this a known side effect of sulpiride? How long should I anticipate before I start feeling normal again?
Answers (1)

8/6/2025, 11:50:56 AM
OpenHealth AI
It's understandable to feel concerned after discontinuing sulpiride, especially since you are experiencing withdrawal symptoms and a decline in your mood and appetite. Let's break down what's happening and focus on steps to help you feel better.
Key Points:
- Discontinuation of sulpiride can lead to withdrawal symptoms, which may include changes in mood, appetite, and physical sensations like palpitations and muscle jerks.
- It is common for individuals to experience a return or worsening of symptoms after stopping medication, particularly if it was used to manage anxiety and depression.
Explanation:
Sulpiride is an antipsychotic medication that can affect neurotransmitter levels in the brain. When stopped, your body may need time to adjust back to its normal state without the medication, leading to symptoms like low mood, appetite changes, and physical effects (such as palpitations and muscle jerks). While these symptoms can be distressing, they are not uncommon.
Usually, the physical effects from stopping such medications can last a few weeks, but individual experiences vary. It's important to monitor your symptoms closely.
Next Steps:
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Stay Hydrated and Nourished: Prioritize drinking water and eating small, nutritious meals. This can help improve your appetite and overall mood.
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Monitor Symptoms: Keep track of how your mood, appetite, and physical symptoms evolve over the next week. Note any patterns or changes—this can be helpful for future discussions with a healthcare provider.
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Practice Relaxation Techniques: Engage in activities that promote relaxation, such as deep breathing exercises, light yoga, or mindfulness meditation. These can help alleviate anxiety and improve your mood.
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Limit Stimulants: If you’re experiencing palpitations, try to avoid caffeine and other stimulants as they can exacerbate these feelings.
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Reach Out for Support: If your symptoms worsen or do not improve within the next week, consider talking to your healthcare provider about your feelings and any ongoing symptoms. They may suggest a supportive approach or consider alternative treatments.
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Seek Professional Guidance: If the muscle jerks or any distressing symptoms continue, it's particularly important to consult a healthcare provider, as they can evaluate your symptoms and provide tailored advice.
Remember, recovery takes time, and it's important to be gentle with yourself during this period. You're not alone in this, and many individuals experience similar challenges when adjusting or discontinuing medications.
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