Is It Normal to Experience These Reactions After Taking Prednisolone?
I’m a 26-year-old woman weighing 130 pounds. I suffer from eustachian tube dysfunction, which leads to persistent fluid buildup behind my eardrum, often causing intense pain and sometimes making it hard to hear. Unfortunately, I won’t be able to see an ENT until September 25th, as that was the earliest appointment available. This condition typically flares up whenever I catch a cold or a viral infection, leading to nasal congestion. The moment my nose gets stuffy, I know I’m in trouble; it only takes about a day for ear problems to kick in. While I try to preemptively use treatments like Flonase and antihistamines, nothing alleviates the pain and swelling quite like prednisone. So whenever I’m in significant discomfort, I opt for a six-day Medrol dose pack, and once I complete it, I often feel much better. I should point out that I haven’t experienced any side effects from prednisone in the past, aside from a slight increase in appetite at times. However, about two weeks ago, my ear issues re-emerged. I attempted to manage the situation using Flonase and allergy medication as prescribed by my doctor, but after a few days, nothing improved. Eventually, the pain became unbearable, prompting a visit to urgent care, where the physician confirmed I had fluid trapped in my ear but no signs of infection. They prescribed a Medrol dose pack and sent me home. Now, I’m on day three of the Medrol dose pack, and while the pain is gone, I’ve developed a sore throat, scratchiness, and have been producing mucus—essentially feeling under the weather. This same situation occurred the last time I was on a Medrol dose pack about two months ago, where I had comparable symptoms by the third day. However, the day after I completed the last six-day course, I felt fine again. Now that this is happening again, I’m confused because it’s not something I’ve ever dealt with before; while I’m relieved that the pain has subsided, I’m concerned about stopping the medication early to avoid any complications with my current ailment. Has anyone else experienced something similar? I haven’t been able to find much information online other than accounts of nausea and digestive issues related to prednisone, which isn’t the case for me—it feels more like cold symptoms.
Answers (1)

8/2/2025, 5:40:41 PM
OpenHealth AI
It's great to hear you're feeling relief from the pain due to the Medrol dose pack, but I understand your concerns about the new symptoms you've developed. Experiencing a sore throat, scratchiness, and mucus production after starting a prednisone regimen can be unsettling, especially if it feels similar to a cold. Here's a breakdown to help you understand this situation better and what to do next.
Key Points:
- Common Side Effects of Prednisone: While many people tolerate prednisone well, it can affect individuals differently. You might be experiencing mild side effects or a reaction that can mimic cold symptoms, especially during a change in medication.
- Immune Response: Prednisone can affect your immune system response, potentially making you feel under the weather if you are already dealing with a cold or environmental allergens.
Explanation:
- Sore Throat and Mucus: The sore throat and increased mucus you’re experiencing could be due to a few factors:
- Secondary Effects: The steroid medication can reduce inflammation, which may lead to a temporary imbalance in how your body handles infections or allergens. Thus, while your ear pain has improved, underlying nasal congestion may still affect your throat and cause mucus production.
- Environmental Factors: If you have been exposed to allergens or irritants (like dust, smoke, or pollen), this could contribute to your symptoms as well.
Next Steps:
- Continue the Medrol Dose Pack: Since the pain relief has been significant, it's generally best to complete the course as prescribed to avoid any resurgence of inflammation.
- Symptom Management:
- Stay Hydrated: Drink plenty of fluids to help with mucus production and soothe your throat.
- Throat Comfort: Consider warm salt water gargles or throat lozenges to relieve throat discomfort.
- Watch for Changes: Keep an eye on your symptoms. If your sore throat worsens, if you develop a fever, or if you experience any new symptoms, note these for your upcoming ENT appointment.
- Gentle Monitoring: Keep track of your symptoms as they progress over the next few days. If the information aligns with previous experiences (resolving after stopping the medication), you might simply be in a transitional phase.
Conclusion
While it's common to experience variations in symptoms when taking prednisone, managing your self-care during this period is essential. Completing the dose pack while staying hydrated and monitoring your symptoms can help you navigate this situation effectively. If you have any further questions or concerns, feel free to reach out!
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