Understanding NSAIDs and Safe Dosage
I’m a 35-year-old woman, standing at 5 feet 3 inches tall and weighing 120 pounds, residing in the United States, and I don’t smoke. This morning at 6 AM, I ingested 220 mg of naproxen sodium. My plan is to transition to ibuprofen after the 12-hour period post-naproxen. If I opt to take 600 mg of ibuprofen tonight at 6 PM, would that mean I'm exceeding a safe dosage within a 24-hour timeframe?
Answers (1)

7/30/2025, 7:50:41 PM
OpenHealth AI
You've raised an important question regarding the use of NSAIDs (non-steroidal anti-inflammatory drugs) and their safe dosages. Let's break down your situation regarding naproxen and ibuprofen.
Summary of Key Points:
- Naprosyn Dose: You've taken 220 mg of naproxen at 6 AM.
- Ibuprofen Plan: You plan to take 600 mg of ibuprofen at 6 PM.
- Dosage Considerations: It's essential to monitor cumulative dosing and timing to avoid potential adverse effects.
Explanation:
- Naproxen: The typical over-the-counter dose for naproxen is 220 mg to 500 mg every 12 hours, not exceeding 1,000 mg in 24 hours unless prescribed otherwise.
- Ibuprofen: For adults, the standard dosage is typically 200 mg to 400 mg every 4 to 6 hours, with a maximum of 1,200 mg per day for over-the-counter use in most situations.
In your case:
- If you take 600 mg of ibuprofen at 6 PM, you will have consumed:
- 220 mg naproxen + 600 mg ibuprofen = 820 mg of total NSAID in the day.
This total does not exceed the 1,200 mg maximum limit for ibuprofen dose within that 24-hour period and could be considered safe, provided you have no other underlying health conditions that could affect NSAID metabolism or kidney function.
Next Steps:
- Confirm Timing: Ensure that your naproxen and ibuprofen doses are spaced correctly. You’re already doing this by waiting the 12 hours after your morning dose.
- Monitor your body: Pay attention to how you feel after taking these medications. If you experience any unusual symptoms (like stomach pain, dizziness, or signs of gastrointestinal bleeding such as black stools), stop taking the NSAIDs and seek guidance.
- Stay Hydrated: Drink plenty of water, as NSAIDs can affect kidney function if you are dehydrated.
- Consult if needed: If you're taking other medications or have any underlying health concerns (like a history of stomach ulcers or kidney issues), reevaluate your pain management strategy with a healthcare provider.
By taking these steps, you can safely manage your NSAID usage today. Let me know if you have more questions or concerns!
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