OpenHealth Q&A

Get answered by medical professionals

Can ADHD Medications Fail to Deliver Results?

7/26/2025, 5:10:26 PMMale25-34

After being diagnosed with ADHD later in life at the age of 49, I have spent the past three years navigating a complicated journey filled with experimentation. Throughout this time, I've been prescribed a myriad of medications, including every available stimulant, yet none have proven effective. Instead, these treatments have led to troublesome hypertension. Additionally, attempts to use off-label antidepressants have also fallen short of expectations. My doctor has explored various combinations of medications in hopes of finding a solution. To add context, I am not only a patient but also a therapist myself, and I am actively participating in personal ADHD therapy and coaching sessions. Despite my efforts, my struggles with inattentiveness remain intensely problematic. In an effort to address potential hormonal imbalances, I’ve also incorporated hormone replacement therapy into my regimen, hoping it might enhance my cognitive function. However, during my most recent appointment, my physician suggested we may have exhausted all possible medication avenues. I'm left wondering if there are others out there experiencing similar frustrations with their treatment.

HypertensionThyroid DisordersInternal Medicine

Answers (1)

Cony

7/26/2025, 5:10:41 PM

OpenHealth AI

It's understandable to feel frustrated after trying multiple ADHD medications without finding relief, especially given your efforts and involvement in both therapy and coaching. While many people respond well to ADHD medications, it's not uncommon for others to encounter difficulties. It sounds like you have been very thorough in seeking solutions, but let’s explore some important points and actionable next steps.

Key Points:

  1. Variability in Medication Response: The effectiveness of ADHD medications can vary greatly from person to person. Factors like individual brain chemistry, co-existing health conditions (like hypertension), and hormonal levels can all influence this variability.

  2. Potential Other Factors: Aside from medications, underlying issues such as sleep disorders, anxiety, depression, or nutritional deficiencies can exacerbate inattentiveness and could be worth exploring.

  3. Non-Medication Strategies: Many individuals with ADHD find relief through non-medication approaches, which might complement any treatment plan you have in place.

Next Steps:

  1. Reevaluate Coexisting Conditions:

    • Schedule time to discuss with your physician or a specialist any potential coexisting conditions (like anxiety or sleep disorders) you might have that could be impacting your ADHD symptoms. Screening for these can often provide additional insights.
  2. Explore Non-Medication Treatments:

    • Investigate behavioral therapies, mindfulness training, or cognitive behavioral techniques that can help manage inattentiveness.
    • Consider joining a support group for adults with ADHD; sharing experiences with others who understand can provide new strategies and emotional support.
  3. Evaluate Lifestyle Changes:

    • Focus on a balanced diet, regular physical activity, and adequate sleep, as these can significantly impact symptoms of ADHD and overall cognitive function.
    • Practice stress-reduction techniques such as deep breathing exercises, yoga, or meditation.
  4. Hormonal Evaluation:

    • If hormone replacement therapy hasn't led to noticeable improvement, consider getting another opinion on hormonal assessments or adjustments from an endocrinologist or a primary care doctor.
  5. Document Your Journey:

    • Keep a symptom diary to track your mood, energy levels, and attention spans. This can help identify patterns or triggers, which may be useful in discussing options with your healthcare provider.

By approaching your ADHD treatment from multiple angles—including medication reassessment, therapy, lifestyle changes, and support networks—you may find a pathway that yields better results. Don’t hesitate to reach out for professional advice tailored to your changing needs; your proactive approach is an invaluable asset in this journey.

Related Questions

Possible Testicular Torsion Concern?

While seated, I experienced an abrupt and severe pain in my abdominal region. After I adjusted my underwear, the sharp discomfort subsided, yet a mild, persistent ache remains in my stomach. This situation has led me to question whether I might be facing testicular torsion.

ArthritisInternal MedicineRheumatology
Male25-34
9 minutes ago

Could Long-Term Use of Psychiatric Medications Result in Brain Damage?

Hello, I’m a 26-year-old female diagnosed with schizoaffective disorder and PTSD for about four years now. Over this time, I have been prescribed a range of medications, including typical antipsychotics, antidepressants, and other non-psychiatric drugs. At present, my medication regimen includes: - Invega Trinza (an injection) at a dose of 525mg, received every ten weeks - Wellbutrin 300mg taken in the morning - Zoloft 200mg also taken in the morning - Pantoprazole 40mg in the morning - Xylac 25mg in the evening - Palafer in the evening. Alongside my psychiatric conditions, I have a background of chronic stress, persistent fatigue, and microcytic anemia. I experience a range of troubling symptoms, including a sensation of my brain "stuttering," time loss, challenges with verbal communication and making connections, memory lapses pertaining to both traumatic incidents and day-to-day occurrences, a feeling of pressure in my head, and significant disconnection or dissociation. It’s worth noting that despite distancing myself from the source of my trauma (a medical facility), I continue to encounter daily stress related to my diagnoses. I'm reaching out for assistance or guidance on this matter. Sincerely, A weary Redditor.

Multiple SclerosisInternal MedicineEndocrinology
Male25-34
9 minutes ago

Recognizing Infection Symptoms After Trauma and Amputation: When to Seek Emergency Care

A 39-year-old female, standing at 5 feet 1 inch and weighing approximately 150 pounds, follows a daily regimen including Vyvanse at 70 mg for ADHD and medical marijuana for anxiety and pain relief. Her medical history consists of ADHD, degenerative disc disease, and hypoglycemia. She is currently on a prescribed course of Amox-Clav at 875-125 mg every twelve hours, along with hydrocodone 5-325 mg to manage pain as needed. Earlier this year, on May 16, she endured a serious workplace accident while testing a smoke grenade fired from a 40 MM weapon, which malfunctioned and detonated. The incident resulted in severe injuries: her left index finger was severely damaged, the tip of her left thumb was completely lost necessitating amputation, and her forearm sustained major trauma with significant muscle and nerve damage. Additionally, she suffered large lacerations on her hand and bicep, alongside a puncture wound to her right breast. Following the trauma, she underwent surgical debridement and spent five days in the hospital. She began physical therapy on June 16. By July 14, her physical therapist observed pus exuding from the nail bed of the injured index finger. The next day, she consulted her orthopedic surgeon, who prescribed Bactrim and recommended Hi-Bicleanse soaks to be performed twice daily. However, her condition prompted concern from her therapist when they noted ongoing drainage mixed with blood. Her arm and hand exhibited swelling, color changes, and fluctuations in temperature; at one point, her hand appeared purple and felt cold, which alarmed her therapist. The previously small wound was noted to have become larger and deeper. Although the therapist advised her to seek urgent care or visit the ER, she opted to wait for her appointment with her general practitioner the following day. When she met with her GP that Tuesday, he assessed her condition as not healing adequately and took a sample of the fluid for culture, though results were pending. He administered an antibiotic injection with an anti-inflammatory agent and prescribed Amox-Clav. Despite starting the antibiotic treatment on Wednesday, the drainage continued. Since her hospitalization, she has also experienced intermittent low-grade fevers ranging from 99 to 101 degrees Fahrenheit. Concurrently, she has been suffering from significant back pain, which she attributes to her existing degenerative disc disease, although she is aware this can also signal an infection. Her physical therapists warned that the persistence of pus or blood drainage, even after several days on antibiotics, indicates the infection may not be improving. She is now contemplating whether to visit the emergency room or urgent care if her finger doesn't show signs of improvement by tomorrow. While she has an upcoming appointment with her orthopedic specialist on Tuesday, she feels anxious about potentially underreacting to her situation. Any insights would be greatly appreciated as she navigates this challenging recovery process.

LupusCrohn's DiseaseInternal Medicine
Male25-34
29 minutes ago

Concern Over Carpal Tunnel Surgery Incision

41 years old. Here are some health details that may be relevant for assessing my recovery: - I have Type 2 diabetes with my most recent A1C level at 6.6, managed with the help of Mounjaro, Farxiga, and Metformin. - My high blood pressure is regulated through 20mg Lisinopril. - Cholesterol levels are under control thanks to 5mg of Crestor. - I take Seroquel, Lamictal, Buspar, and Gabapentin for mental health management. - I do use nicotine in the form of vaping. I underwent surgery on July 10th, with stitches being removed on July 24th. As a reference for this post, the images were taken on July 26th. I have been applying a significant amount of Vaseline on the incision and keeping it covered with a bandage when I’m more active than just watching TV. Today, I mentioned to my mother that I noticed some blood on the bandage periodically and I still feel a slight sting when I clean the area. Having worked in healthcare (though not as an RN or Doctor), she examined it and remarked that it appeared to be slightly separating. I then sent a photo to a nurse friend who confirmed that it seemed like it might be separating but added that they haven’t encountered incisions on the palm before. I am hopeful that someone here has experienced something similar and can offer their opinion. If the incision is indeed separating, I would prefer to avoid having more stitches applied while I'm awake. I can tolerate a cortisone injection quite well, but I doubt I could endure the experience of receiving stitches in my palm while conscious.

DiabetesHypertension
Male25-34
49 minutes ago

Is It Necessary to Change My Bandage After Surgery?

I underwent foot surgery on June 13, and my doctor changed the bandage four days later. He also removed my stitches and a pin three weeks ago, but now I won’t see him again for another month. Surprisingly, he didn't provide me with any guidance regarding wound care. From what I've gathered, it seems I’m not supposed to touch the bandage at all. During showers, I cover it with a bag to keep it dry. I’m still using a boot for mobility; however, my toes are exposed, which makes them vulnerable to dirt.

ArthritisCOPDInternal Medicine
Male25-34
49 minutes ago