What Could Be Happening in My Mouth?
A 34-year-old White woman from New York, standing at 5 feet 3 inches and weighing 123 pounds, seeks some advice regarding her troubling symptoms. She is currently taking multivitamins and Zoloft. Her relevant medical background includes a recent course of antibiotics and steroids, which she completed roughly two weeks prior to the emergence of her current issues. It all began about five days ago when she noticed a sore throat. However, this pain felt distinctly different from her usual experiences with strep throat and tonsillitis—this time, it was more intense and localized at the upper back part of her throat. As she observed no noticeable swelling or redness, she assumed it might be a viral infection that would resolve on its own. Fast forward to three or four days ago, she began to experience a burning sensation on her tongue, almost as if a taste bud had become inflamed or irritated. This discomfort gradually spread towards the tip, making it feel as though several taste buds were affected, akin to burning the entire tongue. Yesterday, she noticed that the pain had expanded to the sides of her tongue and the roof of her mouth. Slight swelling appeared on the edges of her tongue, along with red spots on the palate and her uvula. After a visit to urgent care, she was tested for strep throat, which was ruled out; however, she was diagnosed with thrush despite the absence of noticeable white spots. The doctor prescribed her a lidocaine rinse along with a ten-day course of fluconazole. Despite these measures, the pain has become extremely severe since yesterday—over-the-counter medications like Tylenol and Advil have proven ineffective. She is struggling to eat, drink, or even speak, and has now observed new spots resembling blisters on her tongue as of today. She has several inquiries: - Does this appear to be oral thrush to others? She expresses worry about treating potential misdiagnosis since she doesn’t see any white patches. Could her symptoms be indicative of hand, foot, and mouth disease, particularly since she has no rash elsewhere on her body? - With the evolving nature of the blister-like spots, is this an indication of healing or could it suggest that her condition is worsening? She appreciates any insights that others may provide!
Answers (1)

7/26/2025, 5:01:41 AM
OpenHealth AI
I'm sorry to hear that you're experiencing severe discomfort in your mouth and throat. Your symptoms, including the localized pain, burning sensation on the tongue, and the appearance of blister-like spots, can indeed be concerning and warrant close attention.
Main Points:
- Your symptoms could be associated with thrush or another condition such as viral infections or reactions from recent antibiotic use.
- The blister-like spots could be a sign of irritation or an alternative issue rather than a typical healing process.
- Immediate steps should focus on symptom relief and monitoring for any worsening signs.
Explanation:
- Oral Thrush: It is possible to have oral thrush without the typical white patches, particularly in cases where recent antibiotic or steroid use has disrupted the natural balance of oral flora. Symptoms such as burning, discomfort, and red spots may accompany this condition.
- Other Conditions: Hand, foot, and mouth disease typically occurs in children and is characterized by sores in the mouth and a rash elsewhere, so it is less likely if you have no rash. Your symptoms may still align with a viral infection that can cause similar mouth ulcers or irritation.
- Blister-Like Spots: The appearance of new blister-like spots could either indicate irritation from the existing inflammation or the progression of an underlying issue. Given that they are new and you have significant pain, this should be monitored closely.
Next Steps:
- Continue Using Prescribed Medications: Follow the lidocaine rinse and fluconazole regimen as instructed. These can help manage pain and address thrush.
- Symptom Relief: Try soothing options, such as cold foods (like yogurt or smoothies) or warm broth. Avoid spicy, acidic, or irritating foods that may worsen discomfort.
- Hydration: Staying well-hydrated is essential, even if it’s difficult to swallow. Sip on water frequently or try electrolyte solutions.
- Monitor Changes: Keep a close watch on the symptoms. If the pain intensifies or if you notice significant swelling, difficulty breathing, or spreading of the spots, consider seeking immediate medical attention.
- Follow-Up: Since your current treatment has not alleviated the pain, and there are new developments, it would be important to follow up with your healthcare provider for further assessment. They may need to reevaluate your condition and consider other potential diagnoses.
Please take care, and I hope you find relief soon. If you have any further questions, don’t hesitate to reach out!
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