Seeking Insights on Uncommon Donovanosis Cases in the USA
Greetings, I am a 38-year-old male seeking information regarding unusual instances of Donovanosis caused by Klebsiella Granulomatis. Following Giemsa stain analyses from specimens taken from the urethra, mouth, and eye area, Donovan bodies were detected. Despite undergoing a 21-day course of Azithromycin and Doxycycline, treatment was unsuccessful. I reside in the United States and do not engage in drinking, smoking, or recreational drug use. Comprehensive testing has ruled out all other common sexually transmitted infections, showing negative results. I am curious if any medical professionals here have encountered atypical manifestations of Donovanosis, particularly cases that present with systemic dissemination or antibiotic resistance. If you have encountered such cases, or can refer me to a colleague who has, especially within the U.S., I would greatly appreciate any insights into the symptoms exhibited, testing conducted, treatment strategies implemented, or any other pertinent information. Additionally, if there are recommended doctors or medical facilities known for handling these rare scenarios, I would be eager to hear your suggestions, as I am willing to travel for proper care.
Answers (1)
7/25/2025, 10:50:41 AM
OpenHealth AI
It sounds like you’re facing a challenging situation with your diagnosis of Donovanosis. You've undergone significant testing and treatment, and it’s understandable to seek out more information and options for management. Here is a structured and empathetic response to address your situation.
Opening Statement
Donovanosis, caused by Klebsiella granulomatis, is indeed rare in the United States, and treatment challenges such as resistance can complicate management. Ensuring that you have access to the right professional care is critical in addressing your symptoms and the specific characteristics of your case.
Explanation
Donovanosis typically manifests as ulcerative lesions, primarily affecting the genital and perianal areas, but it can occasionally present in atypical areas like the mouth and eyes, as you mentioned. The detection of Donovan bodies through Giemsa stain reinforces your diagnosis. The lack of response to common antibiotics like Azithromycin and Doxycycline may suggest either antibiotic resistance or atypical manifestations that require different management strategies.
Next Steps
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Seek a Specialist: Since Donovanosis is rare, consult with an infectious disease specialist who has experience with rare infections. They can help explore alternative treatments or combinations of antibiotics that may be more effective. Consider facilities affiliated with academic research or hospitals known for tropical diseases.
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Explore Second Opinions: If you haven't consulted a specialist yet, reach out to larger medical centers or universities that may have departments dedicated to rare infections or tropical diseases. They often have more resources and expertise in managing complex cases.
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Document Symptoms: Keep a detailed record of any symptoms, their progression, and any potential triggers. This information can be very useful for healthcare providers to tailor treatment plans.
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Consider Environmental Factors: Discuss any environmental exposures that may contribute to your symptoms with your specialist. Sometimes, co-factors can complicate treatment, and these should be considered.
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Follow-Up Testing: Depending on your specialist's advice, they may recommend follow-up cultures or different types of blood tests to check for antimicrobial resistance or additional underlying conditions.
If you are open to traveling, facilities with infectious disease programs at universities or major hospitals like the Mayo Clinic or Johns Hopkins may provide consultations or second opinions on your case.
Please know your concerns are valid and important. By seeking specialized care, you can work toward finding effective management for your condition. Let me know if you need more specific resources or guidance!
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