Understanding Medication Interactions
As a 20-year-old woman, standing about 5 feet 6 inches tall and weighing 114 kg, I also vape. Currently, my medication regimen includes tramadol, lanzoprazole, a salbutamol inhaler, a fostair inhaler, and folic acid. I am managing several health conditions, including asthma, vasovagal syncope, non-epileptic attack disorder, folate deficiency anemia, and endometriosis. For my endometriosis, I have been prescribed celecoxib and tranexamic acid. My primary worry revolves around celecoxib, which carries a serious black box warning regarding the potential risks of blood clots, heart attacks, and strokes. Meanwhile, tranexamic acid is known to inhibit the body’s ability to dissolve blood clots. I am seeking advice on whether it is safe to combine these two medications. Additionally, I want to point out that while I have never experienced a blood clot personally, my grandmother has had one, and my mother is considered high-risk for developing blood clots.
Answers (1)

7/24/2025, 9:20:38 PM
OpenHealth AI
Combining celecoxib and tranexamic acid requires careful consideration, especially given your concerns about blood clot risks and your family history.
Main Points:
- Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that might increase the risk of blood clots, heart incidents, and strokes.
- Tranexamic acid helps reduce bleeding by preventing the breakdown of blood clots, but it can also pose a risk if blood clots develop.
Explanation: Taking celecoxib and tranexamic acid together, particularly given your family history of blood clotting issues, can be a bit concerning. While it is not automatically unsafe to use both medications, they can interact in a way that may increase your risk for clot-related complications. Your history of vasovagal syncope and current health conditions (like asthma and anemia) add layers of complexity that warrant caution.
Next Steps:
-
Monitor Symptoms: Be vigilant about any new symptoms such as swelling in your legs, chest pain, or sudden shortness of breath, as these could signal clot formation or other complications.
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Medication Review: Compile a list of all your medications and discuss them with a healthcare provider who can give personalized advice based on your full medical history.
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Lifestyle Modifications: Consider implementing lifestyle changes that promote cardiovascular health, such as maintaining a healthy diet, engaging in physical activity suited to your abilities, and avoiding smoking and vaping.
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Family History Awareness: Make sure any healthcare professional you consult is aware of your family history regarding blood clots, as this is an important part of your risk assessment.
If you face significant issues or uncertainties, prioritize contacting a healthcare provider to reassess your medications and their combinations. Your safety and health should be the top priority.
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