Unexpected Allodynia: Seeking Guidance
I’m a 31-year-old male, standing at 6’2” and weighing 170 pounds. Recently, I’ve been experiencing a peculiar sensation reminiscent of a sunburn minus the actual pain, or as though I’m battling a fever (which I’m not). This sensation first emerged in my right leg yesterday but has now spread across my entire back, producing what feels like skin crawling or chills. My job involves working outdoors in Raleigh, where I’ve been sweating profusely, but this is the first occurrence of such a reaction. The feeling is quite intense, akin to having a severe sunburn, but without the pain—only heightened sensitivity, which escalates when I take a deep breath. Initially localized to my right leg, the discomfort seems to have shifted entirely to my back now. Additionally, I’ve been on cyproheptadine for about a week to ten days. While my pharmacist indicated that it could make me more susceptible to sunburn, they didn’t mention anything regarding this unusual skin sensitivity. I’m reaching out for advice, as it feels similar to having a fever over 103°, yet my actual temperature is normal. This has started to cause me some concern.
Answers (1)

7/16/2025, 6:31:08 AM
OpenHealth AI
It sounds like you are experiencing an unusual and concerning skin sensitivity that has spread from your leg to your back. This condition, called allodynia, can manifest as heightened sensitivity in the skin, leading to sensations that feel intense even without pain. It’s understandable to feel alarmed, especially given the increase in symptoms and their intensity. Let's break this down and discuss some actionable steps you can take.
Explanation:
Allodynia can occur for various reasons, including nerve irritation, inflammation, or even reactions to medications. Cyproheptadine, while it’s generally used to treat allergies, can sometimes lead to unusual skin reactions or intensify sensitivity in some individuals. Additionally, working outdoors and sweating can lead to skin irritation or exacerbations of pre-existing conditions, which might explain your symptoms further.
Prioritized Next Steps:
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Monitor Symptoms: Keep a close eye on your symptoms. Note any changes in intensity, and pay attention to any new sensations that may arise. Take note of when the sensitivity seems to worsen.
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Stay Cool and Hydrated: Since you've been sweating profusely, ensure you're staying well-hydrated. Drink plenty of fluids, and try to keep your skin cool. Use a fan or take cool showers if you feel overheated.
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Avoid Irritants: Avoid tight clothing and any products (like lotions or soaps) that may irritate your skin further. Opt for loose-fitting, breathable fabrics that won't exacerbate the sensitivity.
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Rest: Give your body time to recover. If possible, reduce strenuous activities to minimize stress on your body, especially as you’re working outdoors.
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Evaluate Medications: Consider discussing with a healthcare professional whether cyproheptadine or any other medications may relate to your symptoms. A medication review is a prudent step if you notice any correlation.
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Document Your Concerns: Keeping a symptom diary can help you track patterns and intensity over a few days. This information can be beneficial if you decide to discuss these symptoms with a healthcare provider in the future.
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Seek Further Guidance: If symptoms worsen, or if you experience new symptoms such as severe pain, numbness, or other neurological signs, consider reaching out to a healthcare professional for further evaluation. These could indicate an underlying issue that may need more attention.
It's important to listen to your body—your concerns are valid. Take these steps to manage your symptoms and ensure you're supporting your health effectively. Please feel free to reach out if you have more questions or need further clarification.
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