Persistent High Mean Platelet Volume: Should It Be a Concern?
March 5, 2025 12.9 fL Elevated January 9, 2023 12.5 fL Elevated March 15, 2022 13 fL Elevated I am a 23-year-old female who considers herself generally healthy. I occasionally take phentermine 15 mg daily to aid in weight control, but all my blood tests were conducted before I began this medication, rendering any connection irrelevant. I smoke socially, but I do not consume alcohol at all. Over the years, I've undergone three separate blood tests, and each one has indicated that my mean platelet volume (MPV) is elevated. Despite my doctors dismissing it as not a cause for concern, I can't shake off my unease. I have no identified blood disorders, and my platelet count consistently falls within the normal limits; it’s solely my MPV that is repeatedly flagged as elevated. Is it typical for some individuals to maintain a high mean platelet volume chronically? Might this indicate an underlying issue that my doctors have failed to recognize? While I don’t want to overanalyze, the recurring nature of this finding leads me to feel that I’m not receiving a definitive explanation.
Answers (1)

7/13/2025, 3:10:50 AM
OpenHealth AI
Elevated mean platelet volume (MPV) can be concerning, but it's important to understand that it isn't always indicative of a serious health problem. Chronic high MPV can occur in healthy individuals and may not necessarily point to a medical issue, especially if your platelet count is within normal limits.
Understanding MPV:
- MPV measures the average size of your platelets. Larger platelets are often younger and more reactive, which can be linked to conditions like inflammation or certain health disorders.
- However, many people may have elevated MPV without any underlying disease, and various factors can influence this measurement, including lifestyle habits and individual variations.
Next Steps:
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Continue Monitoring: It's crucial to keep regular track of your MPV. Since you have a history of elevation, ensuring continuous monitoring through routine blood tests can help provide more context over time.
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Lifestyle Adjustments: Since you smoke socially, consider reducing or quitting smoking altogether, as it can influence your blood profiles. Improved lifestyle choices like a balanced diet, regular exercise, and adequate hydration can positively impact overall platelet function.
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Document Symptoms: While your doctors haven’t expressed concern, it can be helpful to maintain a diary of any symptoms you experience, including fatigue, unusual bruising, or any other health changes. This information can be useful for future consultations.
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Seek a Second Opinion (if concerned): If your anxiety persists, it might be worthwhile to consult another healthcare professional, perhaps a hematologist, for a more in-depth discussion about your MPV and any potential factors that could contribute to its elevation.
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Focus on Health: Emphasize your overall wellness. Regular check-ups and blood tests can provide peace of mind and help ensure that you remain healthy.
Feeling unease over medical findings is valid, and addressing your concerns with professionals who can provide clarity is important. Keep focusing on aspects of your health you can control while seeking reassurance through ongoing monitoring and lifestyle choices.
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