Understanding Weight Loss While Taking Prednisone
I’m a 45-year-old individual weighing 224 pounds and standing at 1.77 meters tall. My medical history includes lupus (SLE) and asthma, for which I have recently started a daily dosage of 10mg of Prednisone. Now, three weeks into this treatment, I anticipated experiencing common side effects, particularly weight gain. However, to my surprise, I have actually shed 7 pounds! Typically, I deal with swollen ankles, especially during warm weather, which has been prevalent lately. Remarkably, for the first time in many years, my ankles are looking normal again. Additionally, my face, which usually appears quite puffy, has become noticeably slimmer, and overall, I feel less bloated. In fact, I haven’t felt this healthy in 25 years; there are no signs of joint discomfort, rashes, or seasonal allergies affecting me. While I'm thrilled with my current well-being, I find it puzzling because most information suggests that corticosteroids like Prednisone lead to weight gain and fluid retention. However, it seems the opposite has occurred for me. What could explain this unexpected outcome?
Answers (1)
7/10/2025, 9:10:37 AM
OpenHealth AI
It's great to hear that you’re feeling healthier and experiencing positive changes while on Prednisone. Typically, corticosteroids like Prednisone are known to cause weight gain due to fluid retention and increased appetite. However, your experience reflects that individual responses to medications can vary significantly.
Explanation:
In your case, the weight loss and decrease in swelling could be due to several factors:
- Improved Inflammation Control: Prednisone effectively reduces inflammation in conditions like lupus, which may alleviate associated symptoms such as fluid retention in your ankles. This can lead to a more normal appearance and less swelling.
- Diet and Activity Changes: If you've made any adjustments in your diet or physical activity since starting the medication, those changes might contribute to your weight loss.
- Fluid Dynamics: The loss of excess fluid can also contribute to a decrease in weight and bloating, which seems to align with your observation of feeling less puffy.
Next Steps:
- Continue Monitoring Your Weight and Symptoms: Keep track of any changes in your weight, swelling, or other symptoms. This will help you understand how your body reacts over time.
- Stay Hydrated: Drinking plenty of water can help your body manage fluid levels better and support overall health.
- Maintain a Balanced Diet: Focus on nutritious foods that support your energy levels and overall health. Consider incorporating fruits, vegetables, lean proteins, and whole grains.
- Physical Activity: Engage in regular physical activity that suits your ability and health status. This can support weight management and overall well-being.
- Report Any Sudden Changes: If you notice any sudden weight fluctuations, severe changes in swelling, or new symptoms, take note of them and seek guidance if needed.
It's encouraging to see these positive changes, and continuing to prioritize your health will only be beneficial. If you have any more questions or need further clarification, feel free to ask!
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