Persistent Sore Throat? Here's What to Consider
As a 21-year-old female, I've been battling tonsillitis since childhood. A particularly severe episode in April required hospitalization. Recently, I noticed symptoms resurfacing. I was prescribed the typical course of Phenoxymethylpenicillin, taking 2 tablets four times daily for five days; however, my throat showed no signs of improvement. Now, I’ve switched to Clarithromycin, which I've been using for the past 48 hours, yet still, there's no relief in sight. While the appearance of my throat seems to have improved—those white patches have disappeared—the persistent pain is incredibly intense. This kind of prolonged pain is new to me; in the past, I usually felt a reduction in both the infection and discomfort after just a few doses of antibiotics. Does anyone have insights into what might be happening? This ongoing condition is really wearing me down, and the constant antibiotics are taking a toll on my stomach.
Answers (1)

7/8/2025, 6:30:49 AM
OpenHealth AI
I understand that dealing with a persistent sore throat, especially after a history of tonsillitis and multiple antibiotic courses, can be very frustrating and uncomfortable. It’s important to approach this situation carefully and consider potential underlying factors.
Main Points:
- Persistent sore throat post-medication requires investigation.
- You might be experiencing antibiotic resistance or an underlying condition.
- Managing discomfort while addressing the underlying issue is essential.
Explanation:
While antibiotics like Phenoxymethylpenicillin and Clarithromycin are effective against bacterial infections, there are a few possibilities for your persistent symptoms:
- Antibiotic Resistance: Over time, bacteria can become resistant to certain antibiotics, which may mean the current treatment isn't effective.
- Viral Infections: Not all throat infections are caused by bacteria; some might be viral, which would not respond to antibiotics.
- Other Conditions: Chronic tonsillitis can sometimes lead to complications such as abscesses or can be symptomatic of something like gastroesophageal reflux disease (GERD), which can also cause throat pain.
Next Steps:
-
Keep a Symptom Diary: Track your symptoms daily, noting any changes in pain intensity and any other symptoms (such as fever, ear pain, or digestive issues). This can be useful for your healthcare provider.
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Hydration and Soothing Remedies: Stay well-hydrated. Consider using saline throat gargles, lozenges, or warm broths to soothe throat discomfort.
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Avoid Irritants: Stay away from smoke, strong odors, and allergens, which may worsen your symptoms.
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Reassess Antibiotic Use: If there’s no improvement after a few days on Clarithromycin, consider discussing with a healthcare provider about switching antibiotics or exploring non-antibiotic treatments.
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Follow-Up for Further Evaluation: In the absence of relief, a follow-up with a healthcare professional is crucial. They may recommend tests, such as throat swabs or imaging, to rule out other conditions or complications.
It's understandable to feel worn down by this ongoing issue; ensure you are taking care of your overall well-being in the meantime. Feel free to reach out with updates or additional questions!
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