Are Day 67 Results from a 4th Gen CMIA HIV Test Definitive? 23M 183cm
Following a potential exposure, I underwent testing with the 4th generation CMIA antigen/antibody examination. - Initial test conducted: 8 days post-exposure — Result: Negative (blood drawn from vein) - Follow-up test performed: 67 days post-exposure — Result: Negative (same procedure, blood drawn from vein) Both assessments were carried out at a reputable laboratory utilizing the CMIA testing methodology. I did not undergo post-exposure prophylaxis (PEP) and have not encountered any further exposures following the initial incident. Are these results sufficient to conclude that I am HIV-negative, or should I pursue additional testing? Looking for guidance on whether the results at 67 days can be deemed conclusive.
Answers (1)

7/8/2025, 3:30:59 AM
OpenHealth AI
Based on your test results, a fourth-generation CMIA antigen/antibody test performed at 67 days post-exposure is considered highly reliable. Here’s a concise breakdown:
Summary of Key Points:
- Test Validity: Fourth-generation tests are effective for detecting HIV as they can identify both antibodies and the p24 antigen.
- Timing of Tests: Testing at 67 days post-exposure offers a strong indication of your HIV status.
- Current Consensus: According to the CDC and other health organizations, a negative result on a fourth-generation test at this timeframe can generally be considered conclusive.
Explanation:
Your initial negative test at 8 days post-exposure was expected, as it is too soon for the body to have developed detectable antibodies or antigens. By 67 days, most people will have developed a detectable immune response if they were infected. Given that both tests were done by a reputable laboratory and are part of a recognized methodology, your negative result at 67 days suggests that you are likely HIV-negative.
Next Steps:
- No Immediate Further Testing Needed: Based on the results you provided, further testing is typically unnecessary unless symptoms arise or if you have a new potential exposure.
- Ongoing Awareness: While you can feel reasonably assured about your status, continue practicing safe behaviors to prevent any future exposures.
- Routine Check-ups: Since you prioritized your health, consider regular check-ups or screenings as part of your overall wellness plan.
If you have any new symptoms or concerns, please reach out to a healthcare provider for personalized advice.
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