Understanding Pap Smear Results: ASC-US with Negative HPV
Sex: Female Age: 30 years Height: 5 feet 3 inches Weight: 130 pounds Ethnicity: Asian Smoking Status: Non-smoker I'm reaching out for additional insights regarding my recent Pap test results. The findings indicated ASC-US, while the HPV test returned negative. My Family Nurse Practitioner (FNP-C) informed me that I won’t need to undergo another Pap test for three years, nor is a biopsy necessary. However, I must admit that the ASC-US result has left me feeling a bit anxious, which is why I’m looking for others' opinions on this matter. As far as I know, there is no significant family history of cervical cancer. In my early childhood, my mother had a growth removed, but I cannot remember whether it was cancerous or not. Reaching out to see if anyone has had a similar experience or can share insights about what these results might mean for me.
Answers (1)

7/7/2025, 9:10:43 PM
OpenHealth AI
It's completely understandable to feel anxious about your Pap smear results, especially with terms like ASC-US appearing in your report. I’d like to provide some clarity about what this means for you and reassure you about the next steps.
Main Points
Your Pap test result of ASC-US (Atypical Squamous Cells of Undetermined Significance) indicates that some cells in your cervix showed slight abnormalities, but it doesn't necessarily mean you have cancer. The negative HPV test suggests that you do not have the types of human papillomavirus that are most commonly associated with cervical cancer.
Explanation
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Understanding ASC-US: This result is relatively common and means that the lab found some changes in cervical cells, but they are not clear enough to classify as precancerous or cancerous. Because your HPV test is negative, this is a good sign as it reduces the likelihood of significant cervical disease.
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Follow-up Guidelines: The recommendation from your healthcare provider to wait three years before your next Pap test is aligned with guidelines from reputable health organizations like the American College of Obstetricians and Gynecologists (ACOG). The general protocol following an ASC-US result with negative HPV is to continue routine screenings, as most women will have no further issues.
Next Steps
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Monitor Your Health: While waiting for your next Pap test in three years, maintain a record of any unusual symptoms (bleeding, pain, etc.) and report them to your healthcare provider.
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Stay Informed: Continue learning about cervical health, understanding your own body, and what symptoms to watch for. Regular visits to your healthcare provider for general health checks are important.
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Manage Anxiety: It's normal to feel anxious, but try to engage in practices that promote relaxation and well-being, such as mindfulness, exercise, or talking to someone you trust about your concerns.
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Maintain Routine Care: Continue with scheduled gynecological visits and follow any other preventive healthcare recommendations your providers give you.
Lastly, remember that you are not alone in this experience, and many women encounter similar results. If you continue to feel anxious, consider discussing this specifically with your healthcare provider. They can provide additional reassurance and support.
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